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Triplet-Loss Based Siamese Convolutional Neural Network for 4-Way Classification of Alzheimer’s Disease

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Brain Informatics (BI 2022)

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease that causes irreversible damage to several brain regions including the hippocampus causing impairment in cognition, function and behaviour. Earlier diagnosis of the disease will reduce the suffering of the patients and their family members. Towards that aim, this paper presents a Siamese Convolutional Neural Network (CNN) based model using the Triplet-loss function for the 4-way classification of AD. We evaluated our models using both pre-trained and non-pre-trained CNNs. The models’ efficacy was tested on the OASIS dataset and obtained satisfactory results under a data-scarce real-time environment.

This work is funded by the Ministry of Higher Education, Research and Innovation (MoHERI) of the sultanate of Oman under the Block Funding Program (Grant number-MoHERI/BFP/UoTAS/01/2021).

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References

  1. Chitradevi, D., Prabha, S.: Analysis of brain sub regions using optimization techniques and deep learning method in Alzheimer disease. Appl. Soft Comput. 86, 105857 (2020)

    Article  Google Scholar 

  2. Jahan, S., et al.: Explainable AI-based Alzheimer’s prediction and management using multimodal data. Preprints, pp. 1–16 (2022)

    Google Scholar 

  3. Kornblith, S., Shlens, J., Le, Q.V.: Do better ImageNet models transfer better? In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 2661–2671 (2019)

    Google Scholar 

  4. LaMontagne, P.J., et al.: OASIS-3: longitudinal neuroimaging, clinical, and cognitive dataset for normal aging and Alzheimer disease. medRxiv (2019). https://doi.org/10.1101/2019.12.13.19014902. https://www.medrxiv.org/content/early/2019/12/15/2019.12.13.19014902

  5. Liu, C.F., et al.: Using deep Siamese neural networks for detection of brain asymmetries associated with Alzheimer’s disease and mild cognitive impairment. Magn. Reson. Imaging 64, 190–199 (2019)

    Article  Google Scholar 

  6. Mahmud, M., Kaiser, M.S., McGinnity, T.M., Hussain, A.: Deep learning in mining biological data. Cogn. Comput. 13(1), 1–33 (2021). https://doi.org/10.1007/s12559-020-09773-x

    Article  Google Scholar 

  7. Mahmud, M., Kaiser, M.S., Hussain, A., Vassanelli, S.: Applications of deep learning and reinforcement learning to biological data. IEEE Trans. Neural Netw. Learn. Syst. 29(6), 2063–2079 (2018)

    Article  MathSciNet  Google Scholar 

  8. Mehmood, A., Maqsood, M., Bashir, M.: A deep Siamese convolution neural network for multi-class classification of Alzheimer disease. Brain Sci. (2020) https://doi.org/10.3390/brainsci10020084

  9. Mehmood, A., et al.: A transfer learning approach for early diagnosis of Alzheimer’s disease on MRI images. Neuroscience 460, 43–52 (2021)

    Article  Google Scholar 

  10. Nawaz, H., Maqsood, M., Afzal, S., Aadil, F., Mehmood, I., Rho, S.: A deep feature-based real-time system for Alzheimer disease stage detection. Multimed. Tools Appl. 80(28), 35789–35807 (2021). https://doi.org/10.1007/s11042-020-09087-y

    Article  Google Scholar 

  11. Noor, M.B.T., Zenia, N.Z., Kaiser, M.S., Mamun, S.A., Mahmud, M.: Application of deep learning in detecting neurological disorders from magnetic resonance images: a survey on the detection of Alzheimer’s disease, Parkinson’s disease and schizophrenia. Brain Inform. 7(1), 1–21 (2020). https://doi.org/10.1186/s40708-020-00112-2

    Article  Google Scholar 

  12. Ostertag, C., Beurton-Aimar, M., Visani, M., Urruty, T., Bertet, K.: Predicting brain degeneration with a multimodal Siamese neural network. In: 2020 Tenth International Conference on Image Processing Theory, Tools and Applications (IPTA), pp. 1–6. IEEE (2020)

    Google Scholar 

  13. Ruiz, J., Mahmud, M., Modasshir, M., Shamim Kaiser, M., For the Alzheimer’s Disease Neuroimaging Initiative: 3D DenseNet ensemble in 4-way classification of Alzheimer’s disease. In: Mahmud, M., Vassanelli, S., Kaiser, M.S., Zhong, N. (eds.) BI 2020. LNCS (LNAI), vol. 12241, pp. 85–96. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-59277-6_8

  14. Sathiyamoorthi, V., Ilavarasi, A., Murugeswari, K., Ahmed, S.T., Devi, B.A., Kalipindi, M.: A deep convolutional neural network based computer aided diagnosis system for the prediction of Alzheimer’s disease in MRI images. Measurement 171, 108838 (2021)

    Article  Google Scholar 

  15. Schroff, F., Kalenichenko, D., Philbin, J.: FaceNet: a unified embedding for face recognition and clustering. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 815–823 (2015)

    Google Scholar 

  16. Shikalgar, A., Sonavane, S.: Hybrid deep learning approach for classifying Alzheimer disease based on multimodal data. In: Iyer, B., Deshpande, P.S., Sharma, S.C., Shiurkar, U. (eds.) Computing in Engineering and Technology. AISC, vol. 1025, pp. 511–520. Springer, Singapore (2020). https://doi.org/10.1007/978-981-32-9515-5_49

    Chapter  Google Scholar 

  17. Shorfuzzaman, M., Hossain, M.S.: MetaCOVID: a Siamese neural network framework with contrastive loss for n-shot diagnosis of COVID-19 patients. Pattern Recogn. 113, 107700 (2021)

    Article  Google Scholar 

  18. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)

  19. Taigman, Y., Yang, M., Ranzato, M., Wolf, L.: DeepFace: closing the gap to human-level performance in face verification. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1701–1708 (2014)

    Google Scholar 

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Correspondence to Noushath Shaffi .

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Shaffi, N., Hajamohideen, F., Mahmud, M., Abdesselam, A., Subramanian, K., Sariri, A.A. (2022). Triplet-Loss Based Siamese Convolutional Neural Network for 4-Way Classification of Alzheimer’s Disease. In: Mahmud, M., He, J., Vassanelli, S., van Zundert, A., Zhong, N. (eds) Brain Informatics. BI 2022. Lecture Notes in Computer Science(), vol 13406. Springer, Cham. https://doi.org/10.1007/978-3-031-15037-1_23

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  • DOI: https://doi.org/10.1007/978-3-031-15037-1_23

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