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The Regulatory Effects of Taurine on Neurogenesis and Apoptosis of Neural Stem Cells in the Hippocampus of Rats

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Taurine 12

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1370))

Abstract

The promotion of neurogenesis from neural stem cells (NSCs) in the hippocampus was found to be the most fundamental and effective therapy for depression. Our previous studies proved an antidepressive effect of taurine on rats, but the exact mechanism remains unclear. In this study, CUMS model was established in rats, and NSCs were cultured in vitro to investigate the protective effect and mechanisms of taurine on neurogenesis and apoptosis in CUMS rats and glutamate-injured NSCs. The results showed that ki67-positive cells were significantly increased by taurine, while apoptosis in the DG of CUMS rats was significantly inhibited by taurine. In vitro study, cell viability, Brdu+, β-tubulin III+, and GFAP+ cells in taurine-treated cells were significantly higher, while apoptosis rate was lower than the glutamate-treated cells. The protein expression of BDNF and its downstream pathway was upregulated by taurine administration. The results demonstrated that taurine can increase the survival, proliferation, and differentiation of NSCs; this protective effect of taurine may be due to the upregulation of BDNF/ERK/CREB signaling pathway. On the other hand, taurine can also inhibit abnormal apoptosis induced by CUMS or glutamate, the mechanism of which may be due to its antioxidative ability.

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Abbreviations

AD :

Alzheimer’s disease

BDNF :

Brain-derived neurotrophic factor

CNS :

Central nervous system

CUMS :

Chronic unpredictable mild stress

DG :

Dentate gyrus

ECL :

Enhanced chemiluminescence

HRP :

Horseradish peroxidase

MDA :

Malondialdehyde

NSCs :

Neural stem cells

SGZ :

Subgranular zone

SOD :

Superoxide dismutase

TUNEL :

TdT-mediated dUTP nick-end labeling

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Acknowledgments

This work was funded by the National Natural Science Foundation of China (No. 31772694, 31302051, 31972639) and the Scientific Research Funding Projects from the Education Department of Liaoning Province (LSNQN.201906).

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Author notes

  1. Gaofeng Wu and Jiaqi Zhou contributed equally with all other contributors.

Authors and Affiliations

  1. Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, P.R. China

    Gaofeng Wu, Jiaqi Zhou, Maohong Yang, Chang Xu, Huiping Pang, Xia Qin, Shumei Lin, Jiancheng Yang & Jianmin Hu

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  1. Gaofeng Wu
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Correspondence to Jiancheng Yang .

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Editors and Affiliations

  1. Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, USA

    Stephen W. Schaffer

  2. Department of Biology, College of Staten Island, New York, NY, USA

    Abdeslem El Idrissi

  3. Faculty of Bioscience and Biotechnology, Fukui Prefectural University, Eiheiji-cho, Fukui, Japan

    Shigeru Murakami

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Wu, G. et al. (2022). The Regulatory Effects of Taurine on Neurogenesis and Apoptosis of Neural Stem Cells in the Hippocampus of Rats. In: Schaffer, S.W., El Idrissi, A., Murakami, S. (eds) Taurine 12. Advances in Experimental Medicine and Biology, vol 1370. Springer, Cham. https://doi.org/10.1007/978-3-030-93337-1_34

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