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Boundary-Aware Transformers for Skin Lesion Segmentation

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Medical Image Computing and Computer Assisted Intervention – MICCAI 2021 (MICCAI 2021)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12901))

Abstract

Skin lesion segmentation from dermoscopy images is of great importance for improving the quantitative analysis of skin cancer. However, the automatic segmentation of melanoma is a very challenging task owing to the large variation of melanoma and ambiguous boundaries of lesion areas. While convolutional neutral networks (CNNs) have achieved remarkable progress in this task, most of existing solutions are still incapable of effectively capturing global dependencies to counteract the inductive bias caused by limited receptive fields. Recently, transformers have been proposed as a promising tool for global context modeling by employing a powerful global attention mechanism, but one of their main shortcomings when applied to segmentation tasks is that they cannot effectively extract sufficient local details to tackle ambiguous boundaries. We propose a novel boundary-aware transformer (BAT) to comprehensively address the challenges of automatic skin lesion segmentation. Specifically, we integrate a new boundary-wise attention gate (BAG) into transformers to enable the whole network to not only effectively model global long-range dependencies via transformers but also, simultaneously, capture more local details by making full use of boundary-wise prior knowledge. Particularly, the auxiliary supervision of BAG is capable of assisting transformers to learn position embedding as it provides much spatial information. We conducted extensive experiments to evaluate the proposed BAT and experiments corroborate its effectiveness, consistently outperforming state-of-the-art methods in two famous datasets (Code is available at https://github.com/jcwang123/BA-Transformer).

J. Wang and L. Wei—Contributed equally.

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References

  1. Ahn, E., et al.: Automated saliency-based lesion segmentation in dermoscopic images. In: 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 3009–3012. IEEE (2015)

    Google Scholar 

  2. Bi, L., Kim, J., Ahn, E., Kumar, A., Fulham, M., Feng, D.: Dermoscopic image segmentation via multistage fully convolutional networks. IEEE Trans. Biomed. Eng. 64(9), 2065–2074 (2017). https://doi.org/10.1109/TBME.2017.2712771

    Article  Google Scholar 

  3. Bi, L., Kim, J., Ahn, E., Feng, D., Fulham, M.: Automated skin lesion segmentation via image-wise supervised learning and multi-scale superpixel based cellular automata. In: 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI), pp. 1059–1062. IEEE (2016)

    Google Scholar 

  4. Carion, N., Massa, F., Synnaeve, G., Usunier, N., Kirillov, A., Zagoruyko, S.: End-to-end object detection with transformers. In: Vedaldi, A., Bischof, H., Brox, T., Frahm, J.M. (eds.) Computer Vision, ECCV 2020. Lecture Notes in Computer Science, vol. 12346. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-58452-8_13

  5. Chen, J., et al.: TransUNet: transformers make strong encoders for medical image segmentation (2021)

    Google Scholar 

  6. Chen, L.C., Papandreou, G., Schroff, F., Adam, H.: Rethinking atrous convolution for semantic image segmentation. arXiv preprint arXiv:1706.05587 (2017)

  7. Dosovitskiy, A., et al.: An image is worth 16x16 words: transformers for image recognition at scale. arXiv preprint arXiv:2010.11929 (2020)

  8. Gehring, J., Auli, M., Grangier, D., Yarats, D., Dauphin, Y.N.: Convolutional sequence to sequence learning. In: International Conference on Machine Learning, pp. 1243–1252. PMLR (2017)

    Google Scholar 

  9. Gu, Z.: Ce-net: Context encoder network for 2d medical image segmentation. IEEE Trans. Med. Imaging 38(10), 2281–2292 (2019)

    Article  Google Scholar 

  10. Lee, H.J., Kim, J.U., Lee, S., Kim, H.G., Ro, Y.M.: Structure boundary preserving segmentation for medical image with ambiguous boundary. In: 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), pp. 4816–4825 (2020). https://doi.org/10.1109/CVPR42600.2020.00487

  11. Li, Z., Liu, X., Creighton, F.X., Taylor, R.H., Unberath, M.: Revisiting stereo depth estimation from a sequence-to-sequence perspective with transformers. arXiv preprint arXiv:2011.02910 (2020)

  12. Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 3431–3440 (2015)

    Google Scholar 

  13. Mathur, P., et al.: Cancer statistics, 2020: report from national cancer registry programme, India. JCO Glob. Oncol. 6, 1063–1075 (2020)

    Article  Google Scholar 

  14. Prangemeier, T., Reich, C., Koeppl, H.: Attention-based transformers for instance segmentation of cells in microstructures. In: 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 700–707. IEEE (2020)

    Google Scholar 

  15. Tu, Z., Bai, X.: Auto-context and its application to high-level vision tasks and 3d brain image segmentation. IEEE Trans. Pattern Anal. Mach. Intell. 32(10), 1744–1757 (2010). https://doi.org/10.1109/TPAMI.2009.186

    Article  Google Scholar 

  16. Valanarasu, J.M.J., Oza, P., Hacihaliloglu, I., Patel, V.M.: Medical transformer: gated axial-attention for medical image segmentation. arXiv preprint arXiv:2102.10662 (2021)

  17. Vaswani, A., et al.: Attention is all you need (2017)

    Google Scholar 

  18. Yu, F., Koltun, V.: Multi-scale context aggregation by dilated convolutions. arxiv 2015. arXiv preprint arXiv:1511.07122 615 (2019)

  19. Yu, F., Koltun, V., Funkhouser, T.: Dilated residual networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 472–480 (2017)

    Google Scholar 

  20. Yu, L., Chen, H., Dou, Q., Qin, J., Heng, P.: Automated melanoma recognition in dermoscopy images via very deep residual networks. IEEE Trans. Med. Imaging 36(4), 994–1004 (2017). https://doi.org/10.1109/TMI.2016.2642839

    Article  Google Scholar 

  21. Yuan, Y., Chao, M., Lo, Y.C.: Automatic skin lesion segmentation using deep fully convolutional networks with Jaccard distance. IEEE Trans. Med. Imaging 36(9), 1876–1886 (2017)

    Article  Google Scholar 

  22. Zheng, S., et al.: Rethinking semantic segmentation from a sequence-to-sequence perspective with transformers. arXiv preprint arXiv:2012.15840 (2020)

  23. Zhou, Z., Rahman Siddiquee, M.M., Tajbakhsh, N., Liang, J.: UNet++: a nested U-Net architecture for medical image segmentation. In: Stoyanov, D., et al. (eds.) DLMIA/ML-CDS -2018. LNCS, vol. 11045, pp. 3–11. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00889-5_1

    Chapter  Google Scholar 

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Correspondence to Liansheng Wang or Qichao Zhou .

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Wang, J., Wei, L., Wang, L., Zhou, Q., Zhu, L., Qin, J. (2021). Boundary-Aware Transformers for Skin Lesion Segmentation. In: de Bruijne, M., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2021. MICCAI 2021. Lecture Notes in Computer Science(), vol 12901. Springer, Cham. https://doi.org/10.1007/978-3-030-87193-2_20

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  • DOI: https://doi.org/10.1007/978-3-030-87193-2_20

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