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Remodeling of the Bone Marrow Stromal Microenvironment During Pathogenic Infections

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Bone Marrow Niche

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 434))

Abstract

The bone marrow (BM) is the primary hematopoietic organ and a hub in which organismal demands for blood cellular output are systematically monitored. BM tissues are additionally home to a plethora of mature immune cell types, providing functional environments for the activation of immune responses and acting as preferred anatomical reservoirs for cells involved in immunological memory. Stromal cells of the BM microenvironment crucially govern different aspects of organ function, by structuring tissue microanatomy and by directly providing essential regulatory cues to hematopoietic and immune components in distinct niches. Emerging evidence demonstrates that stromal networks are endowed with remarkable functional and structural plasticity. Stress-induced adaptations of stromal cells translate into demand-driven hematopoiesis. Furthermore, aberrations of stromal integrity arising from pathological conditions critically contribute to the dysregulation of BM function. Here, we summarize our current understanding of the alterations that pathogenic infections and ensuing inflammatory conditions elicit on the global topography of the BM microenvironment, the integrity of anatomical niches and cellular interactions, and ultimately, on the regulatory function of diverse stromal subsets.

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Authors and Affiliations

  1. Department of Medical Oncology and Hematology, University and University Hospital Zurich, Häldeliweg 4, 8032, Zurich, Switzerland

    YeVin Mun, Serena Fazio & César Nombela Arrieta

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  1. YeVin Mun
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  2. Serena Fazio
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  3. César Nombela Arrieta
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Correspondence to César Nombela Arrieta .

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Editors and Affiliations

  1. Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan

    Takashi Nagasawa

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Mun, Y., Fazio, S., Arrieta, C.N. (2021). Remodeling of the Bone Marrow Stromal Microenvironment During Pathogenic Infections. In: Nagasawa, T. (eds) Bone Marrow Niche. Current Topics in Microbiology and Immunology, vol 434. Springer, Cham. https://doi.org/10.1007/978-3-030-86016-5_3

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