Skip to main content

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 256))

Included in the following conference series:

Abstract

Lung cancer is the most common cancer around the world, with the highest mortality rate. If the malignant tumors are diagnosed at an early stage, the patient’s survival rate can be improved. Early diagnosis is possible with the help of lung cancer screening using low-dose CT scans. Identifying the malignant nodules in CT scans is quite challenging at an early stage, and hence there is a need of machine learning architecture that can effectively identify malignant and benign lung nodule in lung CT scans. This study combines the deep features extracted from Alexnet and Resnet deep learning models to classify the malignant and non-malignant nodule in CT scan images. The proposed deep learning architecture was experimented on LUNA 16 dataset and achieved an accuracy, sensitivity, specificity, positive predictive value, and Area under Curve (AUC) score of 94.3%, 95.52%, 91.11%, 89.52%, and .96%, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A.: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: Cancer J. Clin. 68(6), 394–424 (2018)

    Google Scholar 

  2. Byrne, S.C., Barrett, B., Bhatia, R.: The impact of diagnostic imaging wait times on the prognosis of lung cancer. Can. Assoc. Radiol. J. 66(1), 53–57 (2015)

    Article  Google Scholar 

  3. Lakshmanaprabu, S.K., Mohanty, S.N., Shankar, K., Arunkumar, N., Ramirez, G.: Optimal deep learning model for classification of lung cancer on CT images. Future Gen. Comput. Syst. 92, 374–382 (2019)

    Article  Google Scholar 

  4. Sun, B., Ma, C., Jin, X., Luo, Y.: Deep sparse auto-encoder for computer aided pulmonary nodules CT diagnosis. In: 2016 13th International Computer Conference on Wavelet Active Media Technology and Information Processing (ICCWAMTIP), Chengdu, pp. 235–238 (2016)

    Google Scholar 

  5. Xie, Y., Zhang, J., Xia, Y., Fulham, M., Zhang, Y.: Fusing texture, shape and deep model-learned information at decision level for automated classification of lung nodules on chest CT. Inf. Fusion 42, 102–110 (2018)

    Article  Google Scholar 

  6. Wei Shen, M., et al.: Multi-crop convolutional neural networks for lung nodule malignancy suspiciousness classification. Pattern Recogn. 61, 663–673 (2017)

    Article  Google Scholar 

  7. Cao, P., et al.: A_2, 1 norm regularized multi-kernel learning for false positive reduction in Lung nodule CAD. Comput. Methods Prog. Biomed. 140, 211–231 (2017)

    Article  Google Scholar 

  8. Ali, I., et al.: Lung nodule detection via deep reinforcement learning. Front. Oncol. 8, 108 (2018)

    Article  Google Scholar 

  9. Dou, Q., Chen, H., Lequan, Y., Qin, J., Heng, P.-A.: Multilevel contextual 3-D CNNs for false positive reduction in pulmonary nodule detection. IEEE Trans. Biomed. Eng. 64(7), 1558–1567 (2017)

    Article  Google Scholar 

  10. Jiang, H., Ma, H., Qian, W., Gao, M., Li, Y.: An automatic detection system of lung nodule based on multigroup patch-based deep learning network. IEEE J. Biomed. Health Inform. 22(4), 1227–1237 (2018)

    Article  Google Scholar 

  11. Singh, G.A.P., Gupta, P.K.: Performance analysis of various machine learning-based approaches for detection and classification of lung cancer in humans. Neural Comput. Appl. 31(10), 6863–6877 (2018)

    Article  Google Scholar 

  12. Causey, J.L., et al.: Highly accurate model for prediction of lung nodule malignancy with CT scans. Sci. Rep. 8, 9286 (2018)

    Article  Google Scholar 

  13. Sun, W., Zheng, B., Qian, W.: Automatic feature learning using multichannel ROI based on deep structured algorithms for computerized lung cancer diagnosis. Comput. Biol. Med. 89, 530–539 (2017)

    Article  Google Scholar 

  14. Yuan, J., Liu, X., Hou, F., Qin, H., Hao, A.: Hybrid-feature-guided lung nodule type classification on CT images. Comput. Graph. 70, 288–299 (2018)

    Article  Google Scholar 

  15. Xie, H., Yang, D., Sun, N., Chen, Z., Zhang, Y.: Automated pulmonary nodule detection in CT images using deep convolutional neural networks. Pattern Recogn. 85, 109–119 (2019)

    Article  Google Scholar 

  16. Gu, Y., et al.: Automatic lung nodule detection using a 3D deep convolutional neural network combined with a multi-scale prediction strategy in chest CTs. Comput. Biol. Med. 103, 220–231 (2018)

    Article  Google Scholar 

  17. Silva, G.L.F., Valente, T.L.A., Silva, A.C., Paiva, A.C., Gattassa, M.: Convolutional neural network-based PSO for lung nodule false positive reduction on CT images. Comput. Methods Prog. Biomed. 162, 109–118 (2018)

    Article  Google Scholar 

  18. Zhan, J., Xia, Y., Zeng, H., Zhang, Y.: NODULe: combining constrained multi-scale LoG filters with densely dilated 3D deep convolutional neural network for pulmonary nodule detection. Neurocomputing 317, 159–167 (2018)

    Article  Google Scholar 

  19. Xie, Y., Zhang, J., Liu, S., Cai, W., Xia, Y.: Lung nodule classification by jointly using visual descriptors and deep features. In: Henning MĂ¼ller, B., et al. (eds.) MCV/BAMBI -2016. LNCS, vol. 10081, pp. 116–125. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-61188-4_11

    Chapter  Google Scholar 

  20. NĂ³brega, R.V.M.D., Peixoto, S.A., da Silva, S.P.P., Filho, P.P.R.: Lung nodule classification via deep transfer learning in CT lung images. In: 2018 IEEE 31st International Symposium on Computer-Based Medical Systems (CBMS), Karlstad, pp. 244–249 (2018)

    Google Scholar 

  21. Chen, J., Shen, Y.: The effect of kernel size of CNNs for lung nodule classification. In: 2017 9th International Conference on Advanced Infocomm Technology (ICAIT), Chengdu, 2017, pp. 340–344 (2017)

    Google Scholar 

  22. Paul, R., et al.: Deep feature transfer learning in combination with traditional features predicts survival among patients with lung adenocarcinoma. Tomography 2(4), 388–395 (2016)

    Article  Google Scholar 

  23. Zhao, C., Han, J., Jia, Y., Gou, F.: Lung nodule detection via 3D U-net and contextual convolutional neural network. Int. Conf. Netw. Netw. Appl. 2018, 356–361 (2018)

    Google Scholar 

  24. Krizhevsky, A., Sutskever, I., Hinton, G.E.: ImageNet classification with deep convolutional neural networks. In: Proceedings of the 25th International Conference on Neural Information Processing Systems - Volume 1 (NIPS 2012). Curran Associates Inc., Red Hook, pp. 1097–1105 (2012)

    Google Scholar 

  25. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: CVPR (2016)

    Google Scholar 

  26. Jin, T., Cui, H., Zeng, S., Wang, X.: Learning deep spatial lung features by 3D convolutional neural network for early cancer detection. In: 2017 International Conference on Digital Image Computing: Techniques and Applications (DICTA), Sydney, NSW, pp. 1–6 (2017)

    Google Scholar 

  27. Wang, Z., Xu, H., Sun, M.: Deep learning based nodule detection from pulmonary CT images. In: 2017 10th International Symposium on Computational Intelligence and Design (ISCID), vol. 1, pp. 370–373 (2017)

    Google Scholar 

  28. Kuan, K., Ravaut, M., Manek, G., Chen, H.: Deep Learning for Lung Cancer Detection: Tackling the Kaggle Data Science Bowl 2017 Challenge. https://arxiv.org/pdf/1705.09435.pdf

  29. Xie, Y., et al.: Knowledge-based collaborative deep learning for benign-malignant lung nodule classification on chest CT. IEEE Trans. Med. Imaging 38(4), 991–1004 (2018)

    Article  Google Scholar 

  30. Setio, A.A.A., et al.: Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: the LUNA16 challenge. Med. Image Anal. 42, 1–13 (2017)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Damodar Reddy Edla .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Naik, A., Edla, D.R., Dharavath, R. (2022). A Deep Feature Concatenation Approach for Lung Nodule Classification. In: Misra, R., Shyamasundar, R.K., Chaturvedi, A., Omer, R. (eds) Machine Learning and Big Data Analytics (Proceedings of International Conference on Machine Learning and Big Data Analytics (ICMLBDA) 2021). ICMLBDA 2021. Lecture Notes in Networks and Systems, vol 256. Springer, Cham. https://doi.org/10.1007/978-3-030-82469-3_19

Download citation

Publish with us

Policies and ethics