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The Adrenergic Nerve Network in Cancer

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Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1329))

Abstract

The central and autonomic nervous systems interact and converge to build up an adrenergic nerve network capable of promoting cancer. While a local adrenergic sympathetic innervation in peripheral solid tumors influences cancer and stromal cell behavior, the brain can participate to the development of cancer through an intermixed dysregulation of the sympathoadrenal system, adrenergic neurons, and the hypothalamo-pituitary-adrenal axis. A deeper understanding of the adrenergic nerve circuitry within the brain and tumors and its interactions with the microenvironment should enable elucidation of original mechanisms of cancer and novel therapeutic strategies.

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Authors and Affiliations

  1. Laboratory of Cancer and Microenvironment, UMR1274-INSERM/iRCM/IBFJ/DRF/CEA, Université de Paris, Université Paris-Saclay, Paris, France

    Claire Magnon

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  1. Claire Magnon
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Correspondence to Claire Magnon .

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  1. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Magnon, C. (2021). The Adrenergic Nerve Network in Cancer. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1329. Springer, Cham. https://doi.org/10.1007/978-3-030-73119-9_15

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