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Beyond Lesion-Load: Tractometry-Based Metrics for Characterizing White Matter Lesions within Fibre Pathways

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Computational Diffusion MRI

Part of the book series: Mathematics and Visualization ((MATHVISUAL))

Abstract

In multiple sclerosis studies, lesion volume (or lesion load) derived from conventional T2 imaging correlates modestly with clinical assessment. Determining which specific white matter pathways are impacted by lesions may provide additional insights regarding task-specific clinical impairment. Using diffusion MRI, we introduce a set of tract-based metrics that go beyond traditional lesion load approaches and show how they relate to task performance (i.e., working memory, information processing and verbal fluency) in a cohort of 40 patients with multiple sclerosis.

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Notes

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Author information

Authors and Affiliations

  1. Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK

    Maxime Chamberland, Mia Winter & Derek K. Jones

  2. Department of Clinical Neuropsychology, University Hospital of Wales, Cardiff, UK

    Mia Winter

  3. Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK

    Thomas A. W. Brice & Emma C. Tallantyre

  4. Helen Durham Centre for Neuroinflammation, University Hospital of Wales, Cardiff, UK

    Emma C. Tallantyre

Authors
  1. Maxime Chamberland
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  2. Mia Winter
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  3. Thomas A. W. Brice
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  4. Derek K. Jones
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  5. Emma C. Tallantyre
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Corresponding author

Correspondence to Maxime Chamberland .

Editor information

Editors and Affiliations

  1. University College London, London, UK

    Noemi Gyori

  2. Centre for Medical Engineering, King's College London, London, UK

    Jana Hutter

  3. Nvidia, Nashville, TN, USA

    Vishwesh Nath

  4. University College London, London, UK

    Marco Palombo

  5. Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark

    Marco Pizzolato

  6. Laboratory of Mathematics in Imaging, Harvard Medical School, Boston, MA, USA

    Fan Zhang

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Chamberland, M., Winter, M., Brice, T.A.W., Jones, D.K., Tallantyre, E.C. (2021). Beyond Lesion-Load: Tractometry-Based Metrics for Characterizing White Matter Lesions within Fibre Pathways. In: Gyori, N., Hutter, J., Nath, V., Palombo, M., Pizzolato, M., Zhang, F. (eds) Computational Diffusion MRI. Mathematics and Visualization. Springer, Cham. https://doi.org/10.1007/978-3-030-73018-5_18

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