Skip to main content

Automatic Segmentation, Localization, and Identification of Vertebrae in 3D CT Images Using Cascaded Convolutional Neural Networks

  • Conference paper
  • First Online:
Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 (MICCAI 2020)

Abstract

This paper presents a method for automatic segmentation, localization, and identification of vertebrae in arbitrary 3D CT images. Many previous works do not perform the three tasks simultaneously even though requiring a priori knowledge of which part of the anatomy is visible in the 3D CT images. Our method tackles all these tasks in a single multi-stage framework without any assumptions. In the first stage, we train a 3D Fully Convolutional Networks to find the bounding boxes of the cervical, thoracic, and lumbar vertebrae. In the second stage, we train an iterative 3D Fully Convolutional Networks to segment individual vertebrae in the bounding box. The input to the second networks have an auxiliary channel in addition to the 3D CT images. Given the segmented vertebra regions in the auxiliary channel, the networks output the next vertebra. The proposed method is evaluated in terms of segmentation, localization, and identification accuracy with two public datasets of 15 3D CT images from the MICCAI CSI 2014 workshop challenge and 302 3D CT images with various pathologies introduced in [1]. Our method achieved a mean Dice score of 96%, a mean localization error of 8.3 mm, and a mean identification rate of 84%. In summary, our method achieved better performance than all existing works in all the three metrics.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Glocker, B., Feulner, J., Criminisi, A., Haynor, D.R., Konukoglu, E.: Automatic localization and identification of vertebrae in arbitrary field-of-view CT scans. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds.) MICCAI 2012. LNCS, vol. 7512, pp. 590–598. Springer, Heidelberg (2012). https://doi.org/10.1007/978-3-642-33454-2_73

    Chapter  Google Scholar 

  2. Glocker, B., Zikic, D., Konukoglu, E., Haynor, D.R., Criminisi, A.: Vertebrae localization in pathological spine CT via dense classification from sparse annotations. In: Mori, K., Sakuma, I., Sato, Y., Barillot, C., Navab, N. (eds.) MICCAI 2013. LNCS, vol. 8150, pp. 262–270. Springer, Heidelberg (2013). https://doi.org/10.1007/978-3-642-40763-5_33

    Chapter  Google Scholar 

  3. Ioffe, S., et al.: Batch normalization: accelerating deep network training by reducing internal covariate shift. In: International Conference on Machine Learning, vol. 37, pp. 448–456 (2015)

    Google Scholar 

  4. Janssens, R., et al.: Fully automatic segmentation of lumbar vertebrae from ct images using cascaded 3d fully convolutional networks. In: IEEE 15th International Symposium Biomedical Imaging, pp. 893–897 (2018)

    Google Scholar 

  5. Jianhua, Y., et al.: A multi-center milestone study of clinical vertebral ct segmentation. Comput. Med. Imaging Graph. 49, 16–28 (2016)

    Article  Google Scholar 

  6. Keshwani, D., Kitamura, Y., Li, Y.: Computation of total kidney volume from CT images in autosomal dominant polycystic kidney disease using multi-task 3D convolutional neural networks. In: Shi, Y., Suk, H.-I., Liu, M. (eds.) MLMI 2018. LNCS, vol. 11046, pp. 380–388. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00919-9_44

    Chapter  Google Scholar 

  7. Kingma, D.P., et al.: Adam: a method for stochastic optimization. arXiv preprint arXiv:1412.6980 (2014)

  8. Klinder, T., et al.: Automated model-based vertebra detection, identification, and segmentationin CT images. Med. Image Anal. 13, 471–482 (2009)

    Article  Google Scholar 

  9. Korez, R., et al.: A framework for automated spine and vertebrae interpolation-based detection and model-based segmentation. In: IEEE 15th International Symposium Biomedical Imaging, vol. 34, pp. 1649–1662 (2015)

    Google Scholar 

  10. Lessmann, N., et al.: Iterative fully convolutional neural networks for automatic vertebra segmentation and identification. Med. Image Anal. 53, 142–155 (2019)

    Article  Google Scholar 

  11. Roth, H.R., et al.: An application of cascaded 3d fully convolutional networks for medical image segmentation. Comput. Med. Imaging Graph. 66, 90–99 (2018)

    Google Scholar 

  12. Suzani, A., Seitel, A., Liu, Y., Fels, S., Rohling, R.N., Abolmaesumi, P.: Fast automatic vertebrae detection and localization in pathological CT scans - a deep learning approach. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 678–686. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_81

    Chapter  Google Scholar 

  13. Yang, D., et al.: Automatic vertebra labeling in large-scale 3D CT using deep image-to-image network with message passing and sparsity regularization. In: Niethammer, M., et al. (eds.) IPMI 2017. LNCS, vol. 10265, pp. 633–644. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-59050-9_50

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Naoto Masuzawa .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Masuzawa, N., Kitamura, Y., Nakamura, K., Iizuka, S., Simo-Serra, E. (2020). Automatic Segmentation, Localization, and Identification of Vertebrae in 3D CT Images Using Cascaded Convolutional Neural Networks. In: Martel, A.L., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. MICCAI 2020. Lecture Notes in Computer Science(), vol 12266. Springer, Cham. https://doi.org/10.1007/978-3-030-59725-2_66

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-59725-2_66

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-59724-5

  • Online ISBN: 978-3-030-59725-2

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics