Abstract
In recent years, an increasing number of investigations has demonstrated the therapeutic potential of molecules targeting the endocannabinoid system. Cannabinoids of endogenous, phytogenic, and synthetic nature have been assessed in a wide variety of disease models ranging from neurological to metabolic disorders. Even though very few compounds of this type have already reached the market, numerous preclinical and clinical studies suggest that cannabinoids are suitable drugs for the clinical management of diverse pathologies.
In this chapter, we will provide an overview of the endocannabinoid system under certain physiopathological conditions, with a focus on neurological, oncologic, and metabolic disorders. Cannabinoids evaluated as potential therapeutic agents in experimental models with an emphasis in the most successful chemical entities and their perspectives towards the clinic will be discussed.
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Notes
- 1.
Clinical trials: THC in Alzheimer Disease - ClinicalTrials.gov. https://clinicaltrials.gov/ct2/results?cond=Alzheimer+Disease&term=THC&cntry=&state=&city=&dist=. Accessed 7 Oct 2019.
- 2.
Clinical trials: cannabinoids in Parkinson Disease-ClinicalTrials.gov. https://clinicaltrials.gov/ct2/results?cond=Parkinson+Disease&term=cannabis&cntry=&state=&city=&dist=. Accessed 3 Oct 2019.
- 3.
Clinical trials: cannabinoids in Cancer-ClinicalTrials.gov. https://clinicaltrials.gov/ct2/results?cond=Cancer&term=cannabinoid&cntry=&state=&city=&dist= Accessed 29 June 2020.
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Morales, P., Reggio, P.H. (2021). Emerging Roles of Cannabinoids and Synthetic Cannabinoids in Clinical Experimental Models. In: Murillo-Rodriguez, E., Pandi-Perumal, S.R., Monti, J.M. (eds) Cannabinoids and Neuropsychiatric Disorders. Advances in Experimental Medicine and Biology, vol 1264. Springer, Cham. https://doi.org/10.1007/978-3-030-57369-0_4
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