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Antimicrobial Application Potential of Phytoconstituents from Turmeric and Garlic

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Bioactive Natural Products for Pharmaceutical Applications

Part of the book series: Advanced Structured Materials ((STRUCTMAT,volume 140))

Abstract

In recent years, natural phytochemicals are gaining much attention for their antimicrobial potential. Garlic and turmeric are most widely used from the natural source, and their constituents directly or indirectly provide various health benefits, especially due to antimicrobial potential. Though the conventional antimicrobial compounds are effective against various pathogens, up till now there is a necessity of effective agents against MDR pathogens. Phytochemicals have been used for their antimicrobial potential from ancient times. These phytochemicals can work by multiple mechanisms, such as by inhibiting target modifying and drug degrading enzymes or as efflux pump inhibitors. The use of natural phytoconstituents (e.g., curcumin from turmeric and allicin from garlic) from these two medicinal plants may be an alternative strategy and can overcome the side effects associated with antibiotics or other allopathic means of treatment. A wide range of indications has revealed the therapeutic efficacy of these compounds on bacterial, viral, and fungal infections. To improve safety and efficacy, these phytoconstituents have been delivered using nanoformulations such as liposomes, hydrogels, and nanoparticles for the treatment against different bacteria, viruses, fungi, and parasites infections. This chapter is attempted to discuss phytochemistry, antimicrobial mechanisms, and application potential of phytoconstituents from turmeric and garlic.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Bhagyoday Tirth Pharmacy College, Sagar, 470002, MP, India

    Shiv Kumar Prajapati & Akanksha Malaiya

  2. Faculty of Ayurveda, Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, UP, India

    Gaurav Mishra

  3. Department of Materials Engineering, Indian Institute of Science, Bangalore, 560012, Karnataka, India

    Ankit Jain & Ashok M. Raichur

  4. Department of Pharmaceutical Sciences, Dr. Harisingh Gour Central University, Sagar, 470003, MP, India

    Nishi Mody

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  1. Shiv Kumar Prajapati
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  2. Gaurav Mishra
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  3. Akanksha Malaiya
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  4. Ankit Jain
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  5. Nishi Mody
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  6. Ashok M. Raichur
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Correspondence to Ankit Jain .

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  1. Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India

    Dilipkumar Pal

  2. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Science, Mayurbhanj, Odisha, India

    Amit Kumar Nayak

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Prajapati, S.K., Mishra, G., Malaiya, A., Jain, A., Mody, N., Raichur, A.M. (2021). Antimicrobial Application Potential of Phytoconstituents from Turmeric and Garlic. In: Pal, D., Nayak, A.K. (eds) Bioactive Natural Products for Pharmaceutical Applications. Advanced Structured Materials, vol 140. Springer, Cham. https://doi.org/10.1007/978-3-030-54027-2_12

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