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Personalized Anesthesia in Hematology

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Personalized Medicine in Anesthesia, Pain and Perioperative Medicine

Abstract

Anesthesia and surgery have a significant effect on hematological parameters, including hemoglobin, hematocrit, coagulation factors, natural anticoagulants, fibrinolytic system etc. that may vary from person to person, mostly due to their unique genetic profile. Anesthesia drugs differ in their metabolism and efficacy, based on the person’s profile, which indicates the importance of pharmacogenetic/pharmacogenomic. Pharmacogenomic, the cornerstone of personalized medicine, can make clearer the physician’s comprehension of the individual’s response to treatment based on his or her genome profile. With detailed hematological parameters and new genome sequencing technologies such as next-generation sequencing (NGS) or high-throughput sequencing, appropriate anesthetic technique and anesthetic agents for the patient can be chosen for safe, less eventful anesthesia and surgery. Since thrombotic and hemorrhagic disorders are potentially serious perioperative complications, with the development of diagnostic tools and our knowledge, preoperative genetic analysis can be useful in predicting the risks, and optimizing the patient’s management. Genetic research and cutting-edge technologies are progressing at a rapid pace, leading to safer, and more particular, personalized anesthesia.

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We highly appreciate Daisy Morant’s valuable work in improving English language of the chapter.

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  1. Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

    Akbar Dorgalaleh, Mehran Bahraini & Sayed Esmaeil Ahmadi

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  1. Cardiac Anesthesiology Department, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Ali Dabbagh

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Dorgalaleh, A., Bahraini, M., Ahmadi, S.E. (2021). Personalized Anesthesia in Hematology. In: Dabbagh, A. (eds) Personalized Medicine in Anesthesia, Pain and Perioperative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-53525-4_11

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