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Electroceutical Approaches for Gastroparesis

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Obesity and Diabetes

Abstract

Gastroparesis is a symptomatic chronic clinical syndrome where there is delayed emptying of the stomach in the absence of mechanical obstruction. Typical symptoms of gastroparesis include early satiety, nausea and vomiting and it severely affects nutritional intake. For patients with diabetes, glycaemic control will be negatively impacted, with possible secondary effects on other organs that affect mortality rate. Conventional drug treatment and nutritional support fail some patients and new therapy options are required. High-frequency electrical stimulation is a treatment strategy that is employed in severe cases of gastroparesis. In this chapter, an overview of the electrophysiological slow waves is given, followed by emerging trends in novel electrical stimulation therapies in the stomach, with an emphasis on gastroparesis.

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Acknowledgements

The authors acknowledge funding support from the Health Research Council of New Zealand, Marsden Fund Council, Medical Technologies Centre of Research Excellence (MedTechCoRE) and the National Institutes of Health (R01 HD 088662 and U18EB021789).

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Authors and Affiliations

  1. Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

    Niranchan Paskaranandavadivel, Recep Avci, Nipuni Nagahawatte & Leo K. Cheng

  2. Department of Electrical and Computer Engineering, New York Institute of Technology, New York, USA

    Aydin Farajidavar

  3. Department of Surgery, Vanderbilt University, Nashville, TN, USA

    Leo K. Cheng

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  1. Niranchan Paskaranandavadivel
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  2. Recep Avci
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Correspondence to Niranchan Paskaranandavadivel .

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  1. Hospital das Clinicas, Sao Paulo University Medical School, Sao Paulo, Brazil

    Joel Faintuch

  2. Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Salomão Faintuch

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Paskaranandavadivel, N., Avci, R., Nagahawatte, N., Farajidavar, A., Cheng, L.K. (2020). Electroceutical Approaches for Gastroparesis. In: Faintuch, J., Faintuch, S. (eds) Obesity and Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-030-53370-0_72

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