Abstract
Electron paramagnetic resonance (EPR) oximetry based on lithium naphthalocyanine paramagnetic crystals as oxygen sensors enables direct measurement of the partial pressure of oxygen (pO2) in tissues. The method uses topical or implantable forms of these oxygen-sensing crystals embedded in a biocompatible siloxane elastomer. This article presents a summary of these sensors for EPR oximetry and their applicability for tissue oxygen measurement in the clinic.
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References
Ahmad R, Kuppusamy P (2010) Theory, instrumentation, and applications of electron paramagnetic resonance oximetry. Chem Rev 110:3212–3236
Mast JM, Kuppusamy P (2018) Hyperoxygenation as a therapeutic supplement for treatment of triple negative breast cancer. Front Oncol 8:527
Meenakshisundaram G, Eteshola E, Pandian RP et al (2009) Oxygen sensitivity and biocompatibility of an implantable paramagnetic probe for repeated measurements of tissue oxygenation. Biomed Microdev 11:817–826
Pandian RP, Parinandi NL, Ilangovan G et al (2003) Novel particulate spin probe for targeted determination of oxygen in cells and tissues. Free Radic Biol Med 35:1138–1148
Prabhat AM, Kuppusamy ML, Naidu SK et al (2018) Supplemental oxygen protects heart against acute myocardial infarction. Front Cardiovasc Med 5:114
Kmiec MM, Hou H, Lakshmi Kuppusamy M et al (2019) Transcutaneous oxygen measurement in humans using a paramagnetic skin adhesive film. Magn Reson Med 81:781–794
Kmiec MM, Tse D, Mast JM et al (2019) Implantable microchip containing oxygen-sensing paramagnetic crystals for long-term, repeated, and multisite in vivo oximetry. Biomed Microdev 21:71
Kuppusamy P, Kmiec MM, Tse D et al (2020) Estimation of pO2 histogram from a composite EPR Spectrum of multiple random implants. Biomed Microdev 22:1
Hou H, Khan N, Gohain S et al (2018) Pre-clinical evaluation of OxyChip for long-term EPR oximetry. Biomed Microdev 20:29
Caston RM, Schreiber W, Hou H et al (2017) Development of the implantable resonator system for clinical EPR oximetry. Cell Biochem Biophys 75:275–283
Hou H, Khan N, Gohain S et al (2017) Dynamic EPR oximetry of changes in intracerebral oxygen tension during induced thromboembolism. Cell Biochem Biophys 75:285–294
Acknowledgments
The research was supported by NIH grants R01 EB004031 and P01 CA190193.
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Kmiec, M.M., Tse, D., Kuppusamy, P. (2021). Oxygen-Sensing Paramagnetic Probes for Clinical Oximetry. In: Nemoto, E.M., Harrison, E.M., Pias, S.C., Bragin, D.E., Harrison, D.K., LaManna, J.C. (eds) Oxygen Transport to Tissue XLII. Advances in Experimental Medicine and Biology, vol 1269. Springer, Cham. https://doi.org/10.1007/978-3-030-48238-1_41
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DOI: https://doi.org/10.1007/978-3-030-48238-1_41
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