Retinoic Acid Signaling and Heart Development

Perl, Eliyahu; Waxman, Joshua S.

doi:10.1007/978-3-030-42282-0_5

Eliyahu Perl^9,10,11 &
Joshua S. Waxman^11,12,13

Part of the book series: Subcellular Biochemistry ((SCBI,volume 95))

1584 Accesses
6 Citations

Abstract

As the first organ to form and function in all vertebrates, the heart is crucial to development. Tightly-regulated levels of retinoic acid (RA) are critical for the establishment of the regulatory networks that drive normal cardiac development. Thus, the heart is an ideal organ to investigate RA signaling, with much work remaining to be done in this area. Herein, we highlight the role of RA signaling in vertebrate heart development and provide an overview of the field’s inception, its current state, and in what directions it might progress so that it may yield fruitful insight for therapeutic applications within the domain of regenerative medicine.

Hearts will never be practical until they are made unbreakable – Wizard of Oz.

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Abbreviations

ALPM:: Anterior Lateral Plate Mesoderm
A-P:: Anterior-Posterior
ASD:: Atrial Septal Defect
AVSD:: Atrioventricular Septal Defect
ATRA:: All-trans Retinoic Acid
CHD:: Congenital Heart Disease
CM:: Cardiomyocytes
DGS:: DiGeorge syndrome
DORV:: Double Outlet Right Ventricle
EMT:: Epithelial-to-Mesenchymal Transition
FHF:: First Heart Field
KO:: Knock Out
OFT:: Outflow Tract
PTA:: Persistent Truncus Arteriosus
RA:: Retinoic Acid
RAR:: Retinoid Acid Receptor
RARE:: Retinoic Acid Response Elements
RXR:: Retinoid X Receptor
SHF:: Second Heart Field
TGA:: Transposition of the great arteries
VA:: Vitamin A
VAD:: Vitamin A Deficiency
VSD:: Ventricular Septal Defect

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Molecular and Developmental Biology Graduate Program, University of Cincinnati, College of Medicine, Cincinnati, OH, 45229, USA
Eliyahu Perl
Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA
Eliyahu Perl
The Heart Institute and Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 45229, USA
Eliyahu Perl & Joshua S. Waxman
Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 45229, USA
Joshua S. Waxman
Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, 45229, USA
Joshua S. Waxman

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Maine Medical Center Research Institute, Scarborough, ME, USA
Mary Ann Asson-Batres
Département of Functional Génomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), Illkirch, France
Cecile Rochette-Egly

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Perl, E., Waxman, J.S. (2020). Retinoic Acid Signaling and Heart Development. In: Asson-Batres, M., Rochette-Egly, C. (eds) The Biochemistry of Retinoid Signaling III. Subcellular Biochemistry, vol 95. Springer, Cham. https://doi.org/10.1007/978-3-030-42282-0_5

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