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Fibroblasts in the Tumor Microenvironment

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Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1234))

Abstract

The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.

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Acknowledgment

The authors thank Associazione Italiana per la Ricerca sul Cancro for research support (AIRC IG 20172 to F.C.)

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Authors and Affiliations

  1. Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy

    Marta Truffi & Fabio Corsi

  2. Department of Biomedical and Clinical Sciences “Luigi Sacco”, Università degli studi di Milano, Milano, Italy

    Marta Truffi, Luca Sorrentino & Fabio Corsi

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  1. Marta Truffi
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  2. Luca Sorrentino
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  3. Fabio Corsi
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Correspondence to Fabio Corsi .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Truffi, M., Sorrentino, L., Corsi, F. (2020). Fibroblasts in the Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1234. Springer, Cham. https://doi.org/10.1007/978-3-030-37184-5_2

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