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CCL22 Signaling in the Tumor Environment

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Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1231))

Abstract

T cell-mediated elimination of malignant cells is one cornerstone of endogenous and therapeutically induced antitumor immunity. Tumors exploit numerous regulatory mechanisms to suppress T cell immunity. Regulatory T cells (T regs) play a crucial role in this process due to their ability to inhibit antitumoral immune responses and they are known to accumulate in various cancer entities. The chemokine CCL22, predominately produced by dendritic cells (DCs), regulates T reg migration via binding to its receptor CCR4. CCL22 controls T cell immunity, both by recruiting T regs to the tumor tissue and by promoting the formation of DC-T reg contacts in the lymph node. Here, we review the current knowledge on the role of CCL22 in cancer immunity. After revising the principal mechanisms of CCL22-induced immune suppression, we address the factors leading to CCL22 expression and ways of targeting this chemokine therapeutically. Therapeutic interventions to the CCL22-CCR4 axis may represent a promising strategy in cancer immunotherapy.

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Authors and Affiliations

  1. Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany

    Natascha Röhrle & David Anz

  2. Institute of Pathology of the Ludwig-Maximilians-Universität München, Munich, Germany

    Max M. L. Knott

  3. Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany

    David Anz

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  1. Natascha Röhrle
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  2. Max M. L. Knott
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  3. David Anz
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Correspondence to David Anz .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA

    Alexander Birbrair

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Röhrle, N., Knott, M.M.L., Anz, D. (2020). CCL22 Signaling in the Tumor Environment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1231. Springer, Cham. https://doi.org/10.1007/978-3-030-36667-4_8

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