Abstract
Monitoring of cerebral tissue oxygen saturation (StO2) by near-infrared spectroscopy (NIRS oximetry) has great potential to reduce the incidence of hypoxic and hyperoxic events and thus prevent long-term disabilities in preterm neonates. Since the light has to penetrate superficial layers (bone, skin and cerebrospinal fluid) before it reaches the brain, the question arises whether these layers influence cerebral StO2 measurement. We assessed this influence on the accuracy of cerebral StO2 values. For that purpose, we simulated light propagation with ‘N-layered medium’ software. It was found that with a superficial layer thickness of ≤6 mm, typical for term and preterm neonates, StO2 accurately reflects cerebral tissue oxygenation.
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Acknowledgments
This work was supported by the Nano-Tera RTD project NewbornCare, the Clinical Research Priority Programs (CRPP) Molecular Imaging Network Zürich (MINZ) of the University of Zurich and the Swiss Cancer Research grant KFS-3732-08-2015 and the Swiss National Science Foundation project 159490. We thank Dr. Salvador Sanchez Majos and Dr. Alexander Kalyanov for inspiring discussions on the topic.
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Ostojic, D. et al. (2020). Impact of Skull Thickness on Cerebral NIRS Oximetry in Neonates: An in silico Study. In: Ryu, PD., LaManna, J., Harrison, D., Lee, SS. (eds) Oxygen Transport to Tissue XLI. Advances in Experimental Medicine and Biology, vol 1232. Springer, Cham. https://doi.org/10.1007/978-3-030-34461-0_5
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DOI: https://doi.org/10.1007/978-3-030-34461-0_5
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