Abstract
The evolutionary highly conserved Notch pathway, which first developed during evolution in metazoans and was first discovered in fruit flies (Drosophila melanogaster), governs many core processes including cell fate decisions during embryonic development. A huge mountain of scientific evidence convincingly demonstrates that Notch signaling represents one of the most important pathways that regulate embryogenesis from sponges, roundworms, Drosophila melanogaster, and mice to humans. In this review, we give a brief introduction on how Notch orchestrates the embryonic development of several selected tissues, summarizing some of the most relevant findings in the central nervous system, skin, kidneys, liver, pancreas, inner ear, eye, skeleton, heart, and vascular system.
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Abbreviations
- BMP:
-
Bone morphogenetic protein
- cKO:
-
Conditional knockout
- CNS:
-
Central nervous system
- DG:
-
Dentate gyrus
- Dll:
-
Delta-like
- E:
-
Embryonic day
- FGF:
-
Fibroblast growth factor
- Hes:
-
Hairy and enhancer of split
- Hf:
-
Hair follicle
- IP:
-
Intermediate progenitor
- IPC:
-
Intermediate progenitor cell
- KO:
-
Knockout
- LV:
-
Lateral ventricle
- LW:
-
Lateral wall
- MET:
-
Mesenchymal-to-epithelial transition
- NEPs:
-
Neuroepithelial cells
- NICD:
-
Notch intracellular domain
- NSCs:
-
Neural stem cells
- OB:
-
Olfactory bulb
- P:
-
Postnatal day
- RA:
-
Retinoic acid
- RGC:
-
Radial glia cell
- RMS:
-
Rostral migratory stream
- SGZ:
-
Subgranular zone
- Shh:
-
Sonic hedgehog
- SVZ:
-
Subventricular zone
- VZ:
-
Ventricular zone
- Wnt:
-
Wingless
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Reichrath, J., Reichrath, S. (2020). Notch Signaling and Embryonic Development: An Ancient Friend, Revisited. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 1218. Springer, Cham. https://doi.org/10.1007/978-3-030-34436-8_2
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