Abstract
The Fused Filament Fabrication technique was used to build PLA scaffolds for bone tissue replacement. Scaffolds with 100% interconnectivity were fabricated using different printing parameters and geometry design. Two temperature values and two extrusion speeds were combined with two different layer thicknesses. The influence of these parameters upon produced scaffold morphology and compressive mechanical properties was assessed. Afterwards, two different geometries were fabricated considering only the best performing parameters, to assess the influence of the main and lateral pores dimension on scaffolds mechanical properties. Specimen morphology was analysed by scanning electron microscopy, to assess the geometrical quality of the produced parts. It was verified that the higher tested temperatures combined with the lower printing speeds increased the overall mechanical strength of produced scaffolds. Low temperatures and high printing speeds were found to limit the amount of material possible to be extruded due to viscosity issues, and introduced scaffold defects. Creating staggered scaffolds with offsets between layers, decreased the resulting scaffold mechanical performance.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Roseti, L., Parisi, V., Petretta, M., Cavallo, C., Desando, G., Bartolotti, I., Grigolo, B.: Scaffolds for bone tissue engineering: state of the art and new perspectives. Mater. Sci. Eng., C 78, 1246–1262 (2017). https://doi.org/10.1016/j.msec.2017.05.017
Do, A.V., Khorsand, B., Geary, S.M., Salem, A.K.: 3D printing of scaffolds for tissue regeneration applications. Adv. Healthc. Mater. 4(12), 1742–1762 (2015)
Guduric, V., Bareille, R., Latour, S., Gr, A.: Characterization of printed PLA scaffolds for bone tissue engineering Characterization of printed PLA scaffolds for bone tissue engineering (2017). https://doi.org/10.1002/jbm.a.36289
Gregor, A., Filová, E., Novák, M., Kronek, J., Chlup, H., Blahnová, V., Barto, M., Ne, A., Ho, J.: Designing of PLA scaffolds for bone tissue replacement fabricated by ordinary commercial 3D printer 1–21 (2017). https://doi.org/10.1186/s13036-017-0074-3
Gong, B., Cui, S., Zhao, Y., Sun, Y., Ding, Q.: Strain-controlled fatigue behaviors of porous PLA-based scaffolds by 3D-printing technology. J. Biomater. Sci. Polym. 28, 2196–2204 (2017)
Moroni, L., De Wijn, J.R., Van Blitterswijk, C.A.: 3D fiber-deposited scaffolds for tissue engineering: Influence of pores geometry and architecture on dynamic mechanical properties. Biomaterials 27, 974–985 (2006)
Germain, L., Fuentes, C.A., Van Vuure, A.W., Dupont-gillain, C.: 3D-printed biodegradable gyroid scaffolds for tissue engineering applications. Mater. Des. 151, 113–122 (2018). https://doi.org/10.1016/j.matdes.2018.04.037
Domingos, M., Gloria, A., Ambrosio, L.: Effect of process parameters on the morphological and mechanical properties of 3D Bioextruded poly (1-caprolactone) scaffolds 1, 56–67 (2012), https://doi.org/10.1108/13552541211193502
Esposito Corcione, C., Gervaso, F., Scalera, F., Padmanabhan, S.K., Madaghiele, M., Montagna, F., Sannino, A., Licciulli, A., Maffezzoli, A.: Highly loaded hydroxyapatite microsphere/PLA porous scaffolds obtained by fused deposition modelling. Ceram. Int. 45, 2803–2810 (2018)
Szojka, A., Lalh, K., Andrews, S.H.J., Jomha, N.M., Osswald, M., Adesida, A.B.: Biomimetic 3D printed scaffolds for meniscus tissue engineering. Bioprinting 8, 1–7 (2017). https://doi.org/10.1016/j.bprint.2017.08.001
Korpela, J., Kokkari, A., Korhonen, H., Malin, M.: Biodegradable and bioactive porous scaffold structures prepared using fused deposition modeling 610–619 (2012). https://doi.org/10.1002/jbm.b.32863
Serra, T., Planell, J.A., Navarro, M.: High-resolution PLA-based composite scaffolds via 3-D printing technology. Acta Biomater. 9(3), 5521–5530 (2013)
Acknowledgements
This work was supported by FCT, through IDMEC-LAETA (project UID/EMS/50022/2019) and CeFEMA (contract Pest-OE/CTM/UI0084/2014).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Baptista, R., Guedes, M. (2020). Design and Printing Parameters Effect on PLA Fused Filament Fabrication Scaffolds. In: Almeida, H., Vasco, J. (eds) Progress in Digital and Physical Manufacturing. ProDPM 2019. Lecture Notes in Mechanical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-030-29041-2_17
Download citation
DOI: https://doi.org/10.1007/978-3-030-29041-2_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-29040-5
Online ISBN: 978-3-030-29041-2
eBook Packages: EngineeringEngineering (R0)