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Moonlighting Functions of Heat Shock Protein 90

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Heat Shock Protein 90 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 19))

Abstract

Hsp90 is a highly expressed and ubiquitous chaperone in eukaryotes and bacteria. It works with hundreds of client proteins and is regulated by dozens of co-chaperones. Its functions in folding, stabilizing, assembling and disassembling proteins and complexes that are involved in many key processes in the cell, including antigen cross-presentation, stabilization of the cytoskeleton, signaling pathways, stabilization of steroid receptors and other transcription factors, assembly and disassembly of transcription machinery, DNA repair, and the cell cycle. This ubiquitous and versatile intracellular protein is found to have even more functions outside the cell. In this review we discuss the idea that Hsp90 is a moonlighting protein with roles as a secreted cytokine and as a cell surface apoptotic signal and receptor for bacterial cells and lipopolysaccharide.

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Abbreviations

A2MR:

Alpha 2 macroglobulin receptor

BMDC:

Bone marrow derived dendritic cells

CD11:

Integrin subunit

CD18:

Integrin subunit

CXCR4:

Chemokine receptor 4

ER:

Endoplasmic reticulum

GDF5:

Growth differentiation factor 5

HEp-2:

Human epithelial type 2

Hsc70:

Heat shock cognate 71 kDa protein

hsp75:

Heat shock protein 75 kDa mitochondrial

Hsp90:

Heat shock protein Hsp 90

HtpG:

High temperature protein G/C62.5

LBP:

Lipopolysaccharide-binding protein

LOX-1:

Lectin-like oxidized LDL receptor-1

LPS:

Lipopolysaccharide

LRP-1:

LDL receptor-related protein 1/ CD91

MoonProt:

Moonlighting proteins database

PTMs:

Post-translational modifications

TLR4:

Toll-like receptor 4

TRAP1:

Heat shock protein 75 kDa mitochondrial

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Acknowledgements

Research on this project in the Jeffery lab is supported by an award from the University of Illinois Cancer Center.

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Authors and Affiliations

  1. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA

    Chang Chen & Constance Jeffery

  2. Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA

    Constance Jeffery

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  1. Chang Chen
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  2. Constance Jeffery
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Correspondence to Constance Jeffery .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Chen, C., Jeffery, C. (2019). Moonlighting Functions of Heat Shock Protein 90. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-23158-3_13

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