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An In Vitro Model of Triple-Negative Breast Cancer

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Human Cell Transformation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1164))

Abstract

We have characterized two highly tumorigenic and metastatic basal B TNBC cell lines, XtMCF and LmMCF, with the additional values of having the normal and early-stage counterparts of them. This model allows the study of the evolution of TNBC, and investigates molecular pathways at different stages of transformation and progression in a relatively constant genetic background. This constitutes an ideal model for developing targeted therapy in two important fields in cancer biology which are the epithelial mesenchymal transition (EMT) and cancer stem cells (CSC).

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Acknowledgements

This work was supported by the Pennsylvania Cancer Cure Grant 6914101, the NIH core grant CA06927 to Fox Chase Cancer Center, the Barbara and Joseph Breitman donation, and the Flyers wives donation. The compound SGI-110 was provided by Astex Pharmaceuticals, Inc., Dublin CA.

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Authors and Affiliations

  1. Breast Cancer Research Laboratory, Fox Chase Cancer Center-Temple Health, Philadelphia, PA, USA

    J. Russo & Y. Su

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  1. J. Russo
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  2. Y. Su
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Correspondence to J. Russo .

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Editors and Affiliations

  1. Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    Johng S. Rhim

  2. Georgetown University Medical Center, Washington, DC, USA

    Anatoly Dritschilo

  3. Department of Medicine, McGill University Health Centre, Montréal, QC, Canada

    Richard Kremer

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Russo, J., Su, Y. (2019). An In Vitro Model of Triple-Negative Breast Cancer. In: Rhim, J., Dritschilo, A., Kremer, R. (eds) Human Cell Transformation. Advances in Experimental Medicine and Biology, vol 1164. Springer, Cham. https://doi.org/10.1007/978-3-030-22254-3_3

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