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Hypoxia and Metabolism in Metastasis

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Hypoxia and Cancer Metastasis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1136))

Abstract

The hypoxic microenvironment is one of the major features of solid tumors, which regulates cell malignancy in multiple ways. As a response to hypoxia, a large number of target genes involved in cell growth, metabolism, metastasis and immunity are activated in cancer cells. Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1β subunit and an oxygen sensitive HIF-1α subunit, thus, adapts to decreased oxygen availability as a transcriptional factor. HIF-1 regulates many genes involved in tumorigenesis. Here, we focus on cancer cell metabolism and metastasis regulated by hypoxia.

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Acknowledgments

This work was supported in part by grants from the National Natural Science Foundation of China (81525022), the strategic priority research program(Pilot study)of the Chinese Academy of Sciences (XDPB10), and the major innovative program of development foundation of Hefei center for physical science and technology (2017FXZY004).

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Authors and Affiliations

  1. Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China

    Tong Zhang, Chenyang Zheng & Huafeng Zhang

  2. Guangzhou First People’s Hospital, School of Medicine, Institutes for Life Sciences, South China University of Technology of China, Guangzhou, China

    Caixia Suo

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  1. Tong Zhang
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  2. Caixia Suo
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  3. Chenyang Zheng
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  4. Huafeng Zhang
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Corresponding author

Correspondence to Huafeng Zhang .

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Editors and Affiliations

  1. Breast and Ovarian Cancer Program, Department of Oncology, The Johns Hopkins School of Medicine, Baltimore, MD, USA

    Daniele M. Gilkes

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Zhang, T., Suo, C., Zheng, C., Zhang, H. (2019). Hypoxia and Metabolism in Metastasis. In: Gilkes, D. (eds) Hypoxia and Cancer Metastasis. Advances in Experimental Medicine and Biology, vol 1136. Springer, Cham. https://doi.org/10.1007/978-3-030-12734-3_6

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