Skip to main content
SpringerLink
Log in

Epilepsy

  • Chapter
  • First Online:
Handbook of Pediatric Behavioral Healthcare

Abstract

Pediatric epilepsy affects 460,000 youth between 0 and 17 years of age in the United States and is one of the most common pediatric neurological disorders, affecting 1% of youth. Epilepsy is increasingly being recognized as a spectrum disorder that goes beyond seizures, as 50% of individuals also experience cognitive and psychiatric comorbidities. Given the multifactorial nature of epilepsy, the role of interdisciplinary care is critically important to the well-being and comprehensive care of youth with epilepsy (YWE). This chapter covers the diagnosis and treatment of epilepsy, as well as the most common psychological comorbidities. For each of the comorbidities, the chapter discusses the prevalence, evidence-based assessment, risk factors, and evidence-based treatment guidelines from the literature. The chapter concludes with a discussion regarding the importance of interdisciplinary care for YWE, and future directions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alwash, R. H., Hussein, M. J., & Matloub, F. F. (2000). Symptoms of anxiety and depression among adolescents with seizures in Irbid, Northern Jordan. Seizure, 9, 412–416.

    Article  PubMed  Google Scholar 

  • Andresen, E. N., Ramirez, M. J., Kim, K. H., Dorfman, A. B., Haut, J. S., Klaas, P. A., … Busch, R. M. (2014). Effects of surgical side and site on mood and behavior outcome in children with pharmacoresistant epilepsy. Frontiers in Neurology, 5, 18.

    Article  PubMed  PubMed Central  Google Scholar 

  • Austin, J. K., Dunn, D. W., Caffrey, H. M., Perkins, S. M., Harezlak, J., & Rose, D. F. (2002). Recurrent seizures and behavior problems in children with first recognized seizures: A prospective study. Epilepsia, 43, 1564–1573.

    Article  PubMed  Google Scholar 

  • Austin, J. K., Harezlak, J., Dunn, D. W., Huster, G. A., Rose, D. F., & Ambrosius, W. T. (2001). Behavior problems in children before first recognized seizures. Pediatrics, 107, 115–122.

    Article  PubMed  Google Scholar 

  • Austin, J. K., Perkins, S. M., Johnson, C. S., Fastenau, P. S., Byars, A. W., deGrauw, T. J., & Dunn, D. W. (2011). Behavior problems in children at time of first recognized seizure and changes over the following 3 years. Epilepsy and Behavior, 21, 373–381.

    Article  PubMed  Google Scholar 

  • Baca, C. B., Vickrey, B. G., Caplan, R., Vassar, S. D., & Berg, A. T. (2011). Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy. Pediatrics, 128, e1532–e1543.

    Article  PubMed  PubMed Central  Google Scholar 

  • Barry, J. J., Ettinger, A. B., Friel, P., Gilliam, F. G., Harden, C. L., Hermann, B. P., … Jones, J. (2008). Consensus statement: The evaluation and treatment of people with epilepsy and affective disorders. Epilepsy and Behavior, 13, S1–S29.

    Article  PubMed  Google Scholar 

  • Beghi, M., Cornaggia, C. M., Frigeni, B., & Beghi, E. (2006). Learning disorders in epilepsy. Epilepsia, 47, 14–18.

    Article  PubMed  Google Scholar 

  • Berg, A. T., Berkovic, S. F., Brodie, M. J., Buchhalter, J., Cross, J. H., van Emde Boas, W., … Scheffer, I. E. (2010). Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia, 51, 676–685.

    Article  PubMed  Google Scholar 

  • Berg, A. T., Caplan, R., & Hesdorffer, D. C. (2011). Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy. Epilepsy and Behavior, 20, 550–555.

    Article  PubMed  Google Scholar 

  • Beyenburg, S., Mitchell, A. J., Schmidt, D., Elger, C. E., & Reuber, M. (2005). Anxiety in patients with epilepsy: Systematic review and suggestions for clinical management. Epilepsy and Behavior, 7, 161–171.

    Article  PubMed  Google Scholar 

  • Birmaher, B., Williamson, D. E., Dahl, R. E., Axelson, D. A., Kaufman, J., Dorn, L. D., & Ryan, N. D. (2004). Clinical presentation and course of depression in youth: Does onset in childhood differ from onset in adolescence? Journal of the American Academy of Child and Adolescent Psychiatry, 43, 63–70.

    Article  PubMed  Google Scholar 

  • Blocher, J. B., Fujikawa, M., Sung, C., Jackson, D. C., & Jones, J. E. (2013). Computer-assisted cognitive behavioral therapy for children with epilepsy and anxiety: A pilot study. Epilepsy and Behavior, 27, 70–76.

    Article  PubMed  Google Scholar 

  • Brna, P. M., Gordon, K. E., Woolridge, E., Dooley, J. M., & Wood, E. (2017). Perceived need for restrictions on activity for children with epilepsy. Epilepsy and Behavior, 73, 236–239.

    Article  PubMed  Google Scholar 

  • Brooks-Kayal, A. (2010). Epilepsy and autism spectrum disorders: Are there common developmental mechanisms? Brain Development, 32, 731–738.

    Article  PubMed  Google Scholar 

  • Brunklaus, A., Dorris, L., & Zuberi, S. M. (2011). Comorbidities and predictors of health-related quality of life in Dravet syndrome. Epilepsia, 52, 1476–1482.

    Article  PubMed  Google Scholar 

  • Butterbaugh, G., Olejniczak, P., Roques, B., Costa, R., Rose, M., Fisch, B., … Skinner, J. (2004). Lateralization of temporal lobe epilepsy and learning disabilities, as defined by disability-related civil rights law. Epilepsia, 45, 963–970.

    Article  PubMed  Google Scholar 

  • Caplan, R., Siddarth, P., Gurbani, S., Hanson, R., Sankar, R., & Shields, W. D. (2005). Depression and anxiety disorders in pediatric epilepsy. Epilepsia, 46(5), 720–730.

    Article  PubMed  Google Scholar 

  • Clarke, D. F., Roberts, W., Daraksan, M., Dupuis, A., McCabe, J., Wood, H., … Weiss, S. K. (2005). The prevalence of autistic spectrum disorder in children surveyed in a tertiary care epilepsy clinic. Epilepsia, 46, 1970–1977.

    Article  PubMed  Google Scholar 

  • Cohen, R., Senecky, Y., Shuper, A., Inbar, D., Chodick, G., Shalev, V., & Raz, R. (2013). Prevalence of epilepsy and attention-deficit hyperactivity (ADHD) disorder: A population-based study. Journal of Child Neurology, 28, 120–123.

    Article  PubMed  Google Scholar 

  • Cramer, J. A., Westbrook, L. E., Devinsky, O., Perrine, K., Glassman, M. B., & Camfield, C. (1999). Development of the quality of life in epilepsy inventory for adolescents: The QOLIE-AD-48. Epilepsia, 40, 1114–1121.

    Article  PubMed  Google Scholar 

  • Department of Education. (2010). Building the legacy: IDEA 2004. Retrieved January 28, 2011, from http://idea.ed.gov/.

  • Dunn, D. W., Austin, J. K., & Huster, G. A. (1997). Behaviour problems in children with new-onset epilepsy. Seizure, 6, 283–287.

    Article  PubMed  Google Scholar 

  • Ekinci, O., Titus, J. B., Rodopman, A. A., Berkem, M., & Trevathan, E. (2009). Depression and anxiety in children and adolescents with epilepsy: Prevalence, risk factors, and treatment. Epilepsy and Behavior, 14, 8–18.

    Article  PubMed  Google Scholar 

  • Ettinger, A. B., Weisbrot, D. M., Nolan, E. E., Gadow, K. D., Vitale, S. A., Andriola, M. R., … Hermann, B. P. (1998). Symptoms of depression and anxiety in pediatric epilepsy patients. Epilepsia, 39, 595–599.

    Article  PubMed  Google Scholar 

  • Eyberg, S. M., Nelson, M. M., & Boggs, S. R. (2008). Evidence-based psychosocial treatments for children and adolescents with disruptive behavior. Journal of Clinical Child and Adolescent Psychology, 37, 215–237.

    Article  PubMed  Google Scholar 

  • Fastenau, P. S., Jianzhao, S., Dunn, D. W., & Austin, J. K. (2008). Academic underachievement among children with epilepsy: Proportion exceeding psychometric criteria for learning disability and associated risk factors. Journal of Learning Disabilities, 41(3), 195–207.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferro, M. A. (2014). Risk factors for health-related quality of life in children with epilepsy: A meta-analysis. Epilepsia, 55, 1722–1731.

    Article  PubMed  Google Scholar 

  • Ferro, M. A., Camfield, C. S., Levin, S. D., Smith, M. L., Wiebe, S., Zou, G., & Speechley, K. N. (2013). Trajectories of health-related quality of life in children with epilepsy: A cohort study. Epilepsia, 54, 1889–1897.

    Article  PubMed  Google Scholar 

  • Fosi, T., Lax-Pericall, M. T., Scott, R. C., Neville, B. G., & Aylett, S. E. (2013). Methylphenidate treatment of attention deficit hyperactivity disorder in young people with learning disability and difficult-to-treat epilepsy: Evidence of clinical benefit. Epilepsia, 54, 2071–2081.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fujikawa, M., Kishimoto, Y., Kakisaka, Y., Jin, K., Kato, K., Iwasaki, M., & Nakasato, N. (2015). Obsessive-compulsive behavior induced by levetiracetam. Journal of Child Neurology, 30, 942–944.

    Article  PubMed  Google Scholar 

  • Garcia-Ramos, C., Lin, J. J., Bonilha, L., Jones, J. E., Jackson, D. C., Prabhakaran, V., & Hermann, B. P. (2016). Disruptions in cortico-subcortical covariance networks associated with anxiety in new-onset childhood epilepsy. NeuroImage: Clinical, 12, 815–824.

    Article  Google Scholar 

  • Gatta, M., Raffagnato, A., Mannarini, S., Balottin, L., Toldo, I., Vecchi, M., & Boniver, C. (2017). Pediatric epilepsy and psychiatric comorbidity: Preliminary observational data from a prospective study. Minerva Pediatrica.

    Google Scholar 

  • Giovagnoli, A. R., & Avanzini, G. (1999). Learning and memory impairment in patients with temporal lobe epilepsy: Relation to the presence, type, and location of brain lesion. Epilepsia, 40, 904–911.

    Article  PubMed  Google Scholar 

  • Glasgow, R. E., Goldstein, M. G., Ockene, J. K., & Pronk, N. P. (2004). Translating what we have learned into practice. Principles and hypothesies for interventions addressing multiple behaviors in primary care. American Journal of Preventative Medicine, 27, 88–101.

    Article  Google Scholar 

  • Glauser, T. A. (2004a). Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patients. Journal of Child Neurology, 19, S25–S38.

    Article  PubMed  Google Scholar 

  • Glauser, T. A. (2004b). Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy. Epilepsy and Behavior, 5, S25–S32.

    Article  PubMed  Google Scholar 

  • Goldberg, J. F., & Burdick, K. E. (2001). Cognitive side effects of anticonvulsants. Journal of Clinical Psychiatry, 62, 27–33.

    Google Scholar 

  • Guilfoyle, S. M., Follansbee-Junger, K., & Modi, A. C. (2013). Development and preliminary implementation of a psychosocial service into standard medical care for pediatric epilepsy. Clinical Practice in Pediatric Psychology, 1, 276–288.

    Article  Google Scholar 

  • Guilfoyle, S. M., Follansbee-Junger, K., Smith, A. W., Combs, A., Ollier, S., Hater, B., & Modi, A. C. (2018). Antiepileptic drug behavioral side effects and baseline hyperactivity in children and adolescents with new-onset epilepsy. Epilepsia., 59, 146–154.

    Article  PubMed  Google Scholar 

  • Guilfoyle, S. M., Monahan, S., Wesolowski, C., & Modi, A. C. (2015). Depression screening in pediatric epilepsy: Evidence for the benefit of a behavioral medicine service in early detection. Epilepsy and Behavior, 44, 5–10.

    Article  PubMed  Google Scholar 

  • Guilfoyle, S. M., Wagner, J. L., Modi, A. C., Junger, K. F., Barrett, L. E., Riisen, A. C., … Weyand, C. (2017). Pediatric epilepsy and behavioral health: The state of the literature and directions for evidence-based interprofessional care, training, and research. Clinical Practice in Pediatric Psychology, 5, 79–90.

    Article  Google Scholar 

  • Guilfoyle, S. M., Wagner, J. L., Smith, G., & Modi, A. C. (2012). Early screening and identification of psychological comorbidities in pediatric epilepsy is necessary. Epilepsy and Behavior, 25, 495–500.

    Article  PubMed  Google Scholar 

  • Hessen, E., Lossius, M. I., Reinvang, I., & Gjerstad, L. (2006). Influence of major antiepileptic drugs on attention, reaction time, and speed of information processing: Results from a randomized, double-blind, placebo-controlled withdrawal study of seizure-free epilepsy patients receiving monotherapy. Epilepsia, 47, 2038–2045.

    Article  PubMed  Google Scholar 

  • Holland, K. D., & Glauser, T. A. (2007). Response to carbamazepine in children with newly diagnosed partial onset epilepsy. Neurology, 69, 596–599.

    Article  PubMed  Google Scholar 

  • Holland, K. D., Monahan, S., Morita, D., Vartzelis, G., & Glauser, T. A. (2010). Valproate in children with newly diagnosed idiopathic generalized epilepsy. Acta Neurologica Scandinavica, 121(3), 149–153.

    Article  PubMed  PubMed Central  Google Scholar 

  • Howlin, P. (2008). Identifying effective interventions for young children with autism spectrum disorders. Journal of Intellectual Disability Research, 52, 817.

    Article  Google Scholar 

  • Janecek, J. K., Winstanley, F. S., Sabsevitz, D. S., Raghavan, M., Mueller, W., Binder, J. R., & Swanson, S. J. (2013). Naming outcome after left or right temporal lobectomy in patients with bilateral language representation by Wada testing. Epilepsy and Behavior, 28, 95–98.

    Article  PubMed  Google Scholar 

  • Jellinek, M. S., Murphy, J. M., Robinson, J., Feins, A., Lamb, S., & Fenton, T. (1988). Pediatric Symptom Checklist: Screening school-age children for psychosocial dysfunction. Journal of Pediatrics, 112, 201–209.

    Article  Google Scholar 

  • Jensen, F. E. (2011). Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience. Epilepsia, 52, 1–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jones, J. E. (2014). Treating anxiety disorders in children and adolescents with epilepsy: What do we know? Epilepsy and Behavior, 39, 137–142.

    Article  PubMed  Google Scholar 

  • Jones, J. E., Blocher, J. B., Jackson, D. C., Sung, C., & Fujikawa, M. (2014). Social anxiety and self-concept in children with epilepsy: A pilot intervention study. Seizure, 23, 780–785.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jones, J. E., Siddarth, P., Gurbani, S., Shields, W. D., & Caplan, R. (2013). Screening for suicidal ideation in children with epilepsy. Epilepsy and Behavior, 29, 521–526.

    Article  PubMed  Google Scholar 

  • Jones, J. E., Watson, R., Sheth, R., Caplan, R., Koehn, M., Seidenberg, M., & Hermann, B. P. (2007). Psychiatric comorbidity in children with new onset epilepsy. Developmental Medicine and Child Neurology, 49(7), 493–497.

    Article  PubMed  Google Scholar 

  • Kanemura, H., Sano, F., Sugita, K., & Aihara, M. (2013). Effects of levetiracetam on seizure frequency and neuropsychological impairments in children with refractory epilepsy with secondary bilateral synchrony. Seizure, 22, 43–47.

    Article  PubMed  Google Scholar 

  • Kanner, A. M. (2017). Psychiatric comorbidities in new onset epilepsy: Should they be always investigated? Seizure, 49, 79–82.

    Article  PubMed  Google Scholar 

  • Kanner, A. M., Schachter, S. C., Barry, J. J., Hesdorffer, D. C., Mula, M., Trimble, M., … LaFrance, W. C., Jr. (2012). Depression and epilepsy: Epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence. Epilepsy and Behavior, 24, 156–168.

    Article  PubMed  Google Scholar 

  • Kerr, M. P., Mensah, S., Besag, F., de Toffol, B., Ettinger, A., Kanemoto, K., … Wilson, S. J. (2011). International consensus clinical practice statements for the treatment of neuropsychiatric conditions associated with epilepsy. Epilepsia, 52, 2133–2138.

    Article  PubMed  Google Scholar 

  • Kim, E. H., Yum, M. S., Kim, H. W., & Ko, T. S. (2014). Attention-deficit/hyperactivity disorder and attention impairment in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy and Behavior, 37, 54–58.

    Article  PubMed  Google Scholar 

  • Kovacs, M. (2010a). The children’s depression inventory 2 (CDI 2) manual. North Tonawanda, NY: Multi-Health Systems.

    Google Scholar 

  • Kovacs, M. (2010b). The children’s depression inventory 2 (CDI 2): Self-report (short) version (CDI 2:SR[S]). North Tonawanda, NY: Multi-Health Systems.

    Google Scholar 

  • Kwong, K. L., Lam, D., Tsui, S., Ngan, M., Tsang, B., Lai, T. S., & Lam, S. M. (2016). Anxiety and depression in adolescents with epilepsy. Journal of Child Neurology, 31, 203–210.

    Article  PubMed  Google Scholar 

  • Lagae, L. (2006). Cognitive side effects of anti-epileptic drugs. The relevance in childhood epilepsy. Seizure, 15(4), 235–241. https://doi.org/10.1016/j.seizure.2006.02.013

    Article  PubMed  Google Scholar 

  • Langberg, J. M., Froehlich, T. E., Loren, R. E., Martin, J. E., & Epstein, J. N. (2008). Assessing children with ADHD in primary care settings. Expert Review of Neurotherapeutics, 8, 627–641.

    Article  PubMed  Google Scholar 

  • Leonard, E. L., & George, M. R. (1999). Psychosocial and neuropsychological function in children with epilepsy. Pediatric Rehabilitation, 3, 73–80.

    Article  PubMed  Google Scholar 

  • Loiselle, K. A., Ramsey, R. R., Rausch, J. R., & Modi, A. C. (2016). Trajectories of health-related quality of life among children with newly diagnosed epilepsy. Journal of Pediatric Psychology, 41, 1011–1021.

    Article  PubMed  PubMed Central  Google Scholar 

  • March, J. S. (2013). Multidimensional Anxiety Scale for Children 2nd Edition (MASC 2). North Tonawanda, NY: Multi-Health Systems Inc.

    Google Scholar 

  • McCauley, E., Carlson, G. A., & Calderon, R. (1991). The role of somatic complaints in the diagnosis of depression in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 631–635.

    Article  PubMed  Google Scholar 

  • Modi, A. C., Junger, K. F., Mara, C. A., Kellermann, T., Barrett, L., Wagner, J., … Varni, J. W. (2017). Validation of the PedsQL Epilepsy Module: A pediatric epilepsy-specific health-related quality of life measure. Epilepsia, 58(11), 1920–1930.

    Article  PubMed  Google Scholar 

  • Moreira, H., Carona, C., Silva, N., Frontini, R., Bullinger, M., & Canavarro, M. C. (2013). Psychological and quality of life outcomes in pediatric populations: A parent-child perspective. Journal of Pediatrics, 163, 1471–1478.

    Article  Google Scholar 

  • Morita, D. A., Glauser, T. A., & Modi, A. C. (2012). Development and validation of the pediatric epilepsy side effects questionnaire. Neurology, 79, 1252–1258.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nakken, K. O., Solaas, M. H., Kjeldsen, M. J., Friis, M. L., Pellock, J. M., & Corey, L. A. (2009). The occurrence and characteristics of auras in a large epilepsy cohort. Acta Neurologica Scandinavica, 119, 88–93.

    Article  PubMed  Google Scholar 

  • Newsom-Davis, I., Goldstein, L. H., & Fitzpatrick, D. (1998). Fear of seizures: An investigation and treatment. Seizure, 7, 101–106.

    Article  PubMed  Google Scholar 

  • Oguz, A., Kurul, S., & Dirik, E. (2002). Relationship of epilepsy-related factors to anxiety and depression scores in epileptic children. Journal of Child Neurology, 17, 37–40.

    Article  PubMed  Google Scholar 

  • Ott, D., Caplan, R., Guthrie, D., Siddarth, P., Komo, S., Shields, W. D., … Chayasirisobhon, S. (2001). Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absence. Journal of the American Academy of Child and Adolescent Psychiatry, 40(8), 907–914.

    Article  PubMed  Google Scholar 

  • Ott, D., Siddarth, P., Gurbani, S., Koh, S., Tournay, A., Shields, W. D., & Caplan, R. (2003). Behavioral disorders in pediatric epilepsy: Unmet psychiatric need. Epilepsia, 44, 591–597.

    Article  PubMed  Google Scholar 

  • Pelham, W. E., Jr., & Fabiano, G. A. (2008). Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 37, 184–214.

    Article  PubMed  Google Scholar 

  • Pellock, J. M. (2004). Defining the problem: Psychiatric and behavioral comorbidity in children and adolescents with epilepsy. Epilepsy and Behavior, 5, 3–9.

    Article  Google Scholar 

  • Plioplys, S. (2003). Depression in children and adolescents with epilepsy. Epilepsy and Behavior, 4, S39–S45.

    Article  PubMed  Google Scholar 

  • Plioplys, S., Dunn, D. W., & Caplan, R. (2007). 10-year research update review: Psychiatric problems in children with epilepsy. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 1389–1402.

    Article  PubMed  Google Scholar 

  • Puka, K., Smith, M. L., Moineddin, R., Snead, O. C., & Widjaja, E. (2016). Health resource utilization varies by comorbidities in children with epilepsy. Epilepsy and Behavior, 57, 151–154.

    Article  PubMed  Google Scholar 

  • Ramsey, R. R., Loiselle, K., Rausch, J. R., Harrison, J., & Modi, A. C. (2016). Predictors of trajectories of epilepsy-specific quality of life among children newly diagnosed with epilepsy. Epilepsy and Behavior, 57, 202–210.

    Article  PubMed  Google Scholar 

  • Reilly, C., Atkinson, P., Das, K. B., Chin, R. F., Aylett, S. E., Burch, V., … Neville, B. G. (2014). Neurobehavioral comorbidities in children with active epilepsy: A population-based study. Pediatrics, 133, e1586–e1593.

    Article  PubMed  Google Scholar 

  • Reynolds, C. R., & Kamphaus, R. W. (2015). Behavior assessment system for children: Third edition. Bloomington, MN: Pearson.

    Google Scholar 

  • Reynolds, C. R., & Richmond, B. O. (1978). What I think and feel: A revised measure of children’s manifest anxiety. Journal of Abnormal Child Psychology, 6, 271–280.

    Article  PubMed  Google Scholar 

  • Reynolds, C. R., & Richmond, B. O. (2008). Revised Children’s Manifest Anxiety Scale: Second edition. Torrance: Western Psychological Services.

    Book  Google Scholar 

  • Russ, S. A., Larson, K., & Halfon, N. (2012). A national profile of childhood epilepsy and seizure disorder. Pediatrics, 129, 256–264.

    Article  PubMed  Google Scholar 

  • Ryan, J. L., McGrady, M. E., Guilfoyle, S. M., Follansbee-Junger, K., Peugh, J. L., Loiselle, K. A., … Modi, A. C. (2016). Quality of life changes and health care charges among youth with epilepsy. Journal of Pediatric Psychology, 41, 888–897.

    Article  PubMed  Google Scholar 

  • Ryan, J. L., McGrady, M. E., Guilfoyle, S. M., Junger, K., Arnett, A. D., & Modi, A. C. (2015). Health care charges for youth with newly diagnosed epilepsy. Neurology, 85, 490–497.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sabaz, M., Lawson, J. A., Cairns, D. R., Duchowny, M. S., Resnick, T. J., Dean, P. M., & Bye, A. M. (2003). Validation of the quality of life in childhood epilepsy questionnaire in American epilepsy patients. Epilepsy and Behavior, 4, 680–691.

    Article  PubMed  Google Scholar 

  • Sabbagh, S. E., Soria, C., Escolano, S., Bulteau, C., & Dellatolas, G. (2006). Impact of epilepsy characteristics and behavioral problems on school placement in children. Epilepsy and Behavior, 9, 573–578.

    Article  PubMed  Google Scholar 

  • Saemundsen, E., Ludvigsson, P., Hilmarsdottir, I., & Rafnsson, V. (2007). Autism spectrum disorders in children with seizures in the first year of life—A population-based study. Epilepsia, 48, 1724–1730.

    Article  PubMed  Google Scholar 

  • Salpekar, J. A., Berl, M. M., Havens, K., Cushner-Weinstein, S., Conry, J. A., Pearl, P. L., … Gaillard, W. D. (2013). Psychiatric symptoms in children prior to epilepsy surgery differ according to suspected seizure focus. Epilepsia, 54, 1074–1082.

    Article  PubMed  Google Scholar 

  • Salpekar, J. A., & Dunn, D. W. (2007). Psychiatric and psychosocial consequences of pediatric epilepsy. Seminars in Pediatric Neurology, 14, 181–188.

    Article  PubMed  Google Scholar 

  • Salpekar, J. A., & Mishra, G. (2014). Key issues in addressing the comorbidity of attention deficit hyperactivity disorder and pediatric epilepsy. Epilepsy and Behavior, 37, 310–315.

    Article  PubMed  Google Scholar 

  • Schraegle, W. A., & Titus, J. B. (2017a). The influence of endophenotypic, disease-specific, and environmental variables on the expression of anxiety in pediatric epilepsy. Epilepsy and Behavior, 75, 90–96.

    Article  PubMed  Google Scholar 

  • Schraegle, W. A., & Titus, J. B. (2017b). The relationship of seizure focus with depression, anxiety, and health-related quality of life in children and adolescents with epilepsy. Epilepsy and Behavior, 68, 115–122.

    Article  PubMed  Google Scholar 

  • Seida, J. K., Ospina, M. B., Karkhaneh, M., Hartling, L., Smith, V., & Clark, B. (2009). Systematic reviews of psychosocial interventions for autism: An umbrella review. Developmental Medicine and Child Neurology, 51, 95–104.

    Article  PubMed  Google Scholar 

  • Seidenberg, M., Beck, N., Geisser, M., Giordani, B., Sackellares, J. C., Berent, S., … Boll, T. J. (1986). Academic achievement of children with epilepsy. Epilepsia, 27, 753–759.

    Article  PubMed  Google Scholar 

  • Sillanpaa, M. (1992). Epilepsy in children: Prevalence, disability, and handicap. Epilepsia, 33, 444–449.

    Article  PubMed  Google Scholar 

  • Smith, G., Wagner, J. L., & Edwards, J. C. (2015a). CE: epilepsy update, part 1: Refining our understanding of a complex disease. American Journal of Nursing, 115, 40–47.

    Article  Google Scholar 

  • Smith, G., Wagner, J. L., & Edwards, J. C. (2015b). CE: Epilepsy update, part 2: Nursing care and evidence-based treatment. American Journal of Nursing, 115, 34–44.

    Article  Google Scholar 

  • Socanski, D., Aurlien, D., Herigstad, A., Thomsen, P. H., & Larsen, T. K. (2013). Epilepsy in a large cohort of children diagnosed with attention deficit/hyperactivity disorders (ADHD). Seizure, 22, 651–655.

    Article  PubMed  Google Scholar 

  • Subcommittee on Attention-Deficit/Hyperactivity Disorder, & Steering Committee on Quality Improvement, & Management. (2011). ADHD: Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics, 128, 1007–1022.

    Article  Google Scholar 

  • Thome-Souza, M. S., Kuczynski, E., & Valente, K. D. (2007). Sertraline and fluoxetine: Safe treatments for children and adolescents with epilepsy and depression. Epilepsy and Behavior, 10, 417–425.

    Article  PubMed  Google Scholar 

  • Thome-Souza, S., Kuczynski, E., Assumpcao, F., Jr., Rzezak, P., Fuentes, D., Fiore, L., & Valente, K. D. (2004). Which factors may play a pivotal role on determining the type of psychiatric disorder in children and adolescents with epilepsy? Epilepsy and Behavior, 5, 988–994.

    Article  PubMed  Google Scholar 

  • Titus, J. B., Kanive, R., Sanders, S. J., & Blackburn, L. B. (2008). Behavioral profiles of children with epilepsy: Parent and teacher reports of emotional, behavioral, and educational concerns on the BASC-2. Psychology in the schools, 45, 892–903.

    Article  Google Scholar 

  • Tovia, E., Goldberg-Stern, H., Ben Zeev, B., Heyman, E., Watemberg, N., Fattal-Valevski, A., & Kramer, U. (2011). The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes. Epilepsia, 52, 1483–1488.

    Article  PubMed  Google Scholar 

  • Tuchman, R., Alessandri, M., & Cuccaro, M. (2010). Autism spectrum disorders and epilepsy: Moving towards a comprehensive approach to treatment. Brain Development, 32, 719–730.

    Article  PubMed  Google Scholar 

  • U.S. Food and Drug Administration. (2008, August 15). Information for healthcare professionals: Suicidal behavior and ideation and antiepileptic drugs. Retrieved August 29, 2014, from http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm100192.htm.

  • Wagner, J. L., Ferguson, P. L., Kellermann, T., Smith, G., & Brooks, B. (2016). Behavioral health referrals in pediatric epilepsy. Epilepsy Research, 127, 72–77.

    Article  PubMed  Google Scholar 

  • Wagner, J. L., Ferguson, P. L., & Smith, G. (2012). The relationship of coping behaviors to depressive symptoms in youth with epilepsy: An examination of caregiver and youth proxy report. Epilepsy and Behavior, 24, 86–92.

    Article  PubMed  Google Scholar 

  • Wagner, J. L., Kellermann, T., Mueller, M., Smith, G., Brooks, B., Arnett, A., & Modi, A. C. (2016). Development and validation of the NDDI-E-Y: A screening tool for depressive symptoms in pediatric epilepsy. Epilepsia, 57, 1265–1270.

    Article  PubMed  Google Scholar 

  • Wagner, J. L., Smith, G., Ferguson, P. L., & Fedele, D. A. (2013). Preliminary psychometrics of the neurological disorders depression inventory for epilepsy-youth. Journal of Child Neurology, 28, 1392–1399.

    Article  PubMed  Google Scholar 

  • Wasterlain, C. G., & Chen, J. W. (2006). Definition and classification of status epilepticus. In C. G. Wasterlain & D. M. Treiman (Eds.), Statsus epilepticus: Mechanisms and management (pp. 11–16). Cambridge, MA: The MIT Press.

    Google Scholar 

  • Weller, E. B., Weller, R. A., Rowan, A. B., & Svadjian, H. (2000). Depressive disorders in children and adolescents). In M. Lewis (Ed.), Child and adolescent psychiatry: A comprehensive textbook (pp. 767–781). Philadelphia, PA: Lippincott Williams & Wilkins Publishers.

    Google Scholar 

  • Williams, J., Steel, C., Sharp, G. B., DelosReyes, E., Phillips, T., Bates, S., … Griebel, M. L. (2003). Anxiety in children with epilepsy. Epilepsy and Behavior, 4, 729–732.

    Article  PubMed  Google Scholar 

  • Wolraich, M. L., Brown, L., Brown, R. T., DuPaul, G., Earls, M., Feldman, H. M., … Visser, S. (2011). ADHD: Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics, 128, 1007–1022.

    Article  PubMed  Google Scholar 

  • Wolraich, M. L., Lambert, W., Doffing, M. A., Bickman, L., Simmons, T., & Worley, K. (2003). Psychometric properties of the Vanderbilt ADHD diagnostic parent rating scale in a referred population. Journal of Pediatric Psychology, 28, 559–567.

    Article  PubMed  Google Scholar 

  • Zack, M. M., & Kobau, R. (2017). National and state estimates of the numbers of adults and children with active epilepsy—United States, 2015. Morbidity and Mortality Weekly Report, 66, 821–825.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital and Medical Center, Cincinnati, OH, USA

    Katherine Follansbee-Junger, Aimee W. Smith, Shanna Guilfoyle & Avani C. Modi

Authors
  1. Katherine Follansbee-Junger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aimee W. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shanna Guilfoyle
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Avani C. Modi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Avani C. Modi .

Editor information

Editors and Affiliations

  1. Department of School Psychology, Graduate School of Applied and Professional Psychology, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA

    Susan G. Forman

  2. Department of School Psychology, Graduate School of Applied and Professional Psychology, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA

    Jeffrey D. Shahidullah

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Follansbee-Junger, K., Smith, A.W., Guilfoyle, S., Modi, A.C. (2018). Epilepsy. In: Forman, S., Shahidullah, J. (eds) Handbook of Pediatric Behavioral Healthcare. Springer, Cham. https://doi.org/10.1007/978-3-030-00791-1_7

Download citation

Publish with us

Policies and ethics

Search

Navigation