Abstract
Immaturity of the developing immune system in the fetus and neonate renders them susceptible to a variety of pathogens, including Toxoplasma gondii. Recent advances in understanding fetal and neonatal immunity, cytokines, and immunogenetics, combined with new knowledge of the biology of T. gondii provide important insights relevant to this potentially devastating infection. Cell-mediated immune responses are the major mechanisms of host defense against T. gondii infection. Herein, we consider ontogeny of innate and specific cell-mediated immune responses in the human fetus and neonate in conjunction with a discussion of immune mechanisms likely to protect humans against T gondii, studies of immunity of humans with congenital and postnatally acquired toxoplasmosis, and work which demonstrates immune mechanisms important in protection against toxoplasmosis in murine models.
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References
Boyer K.a.M R (1998) Toxoplasmosis: Principles and Practice of Pediatric Infectious Disease. In : Long P (ed) Principles and Practice of Pediatric Infectious Disease. Prober, Churchill Livingstone New York, pp. 1421–1448
Deckert-Schluter M et al (1994) Activation of the innate immune system in murine congenital Toxoplasma encephalitis. J Neuroimmunol 53(1):47–51
Mack D JJ, Roberts F, Roberts C, Estes R, David C, Grumet FC, McLeod R (1999) HLAClass II Genes Modify Outcome of Infection. (in preparation)
Versteeg R (1992) NK cells and T cells: mirror images? Immunol Today 13(7):244–247
Schlossman S, BL, Gilks W, Harlan J, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder T, Todd R (1994) Leukocyte Typing. 5’h ed. S S Oxford University Press
Abbas AK, Lichtman AH, Pober JS (1997) Cellular and molecular immunology. 3rd ed. Saunders text and review series. Saunders, Philadlephia: xii, 494 , 8 of plates
Raulet DH (1992) Immunology. A sense of something missing [news; comment]. Nature 358(6381):21–22
Moretta L et al (1992) Allorecognition by NK cells: nonself or no self? Immunol Today 13(8):300–306
Seder RA et al (1993) Interleukin 12 acts directly on CD4’ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci USA, 90(21):10188–10192
Bancroft GJ (1993) The role of natural killer cells in innate resistance to infection. Curr Opin Immunol, 5(4):503–510
Lanier LL (1997) Natural killer cells: from no receptors to too many. Immunity, 6(4):371–378
Moretta A et al (1997) Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev 155:105–117
Agrawal S et al (1999) Cutting Edge: MHC Class I Triggering by a Novel Cell Surface Ligand Costimulates Proliferation of Activated Human T Cells. J Immunol 162(3): 1223–1226
Phillips JH et al (1992) Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon delta proteins. J Exp Med 175(4):1055–1056
Lewis DB, Wilson CB (1995) Developmental Immunology and Role of Host Defenses in Neonatal Susceptibility. In : Remington JS, Klein RB (eds) Infections of the Fetus and Newborn Infant. WB Saunders Company: Philadelphia. pp. 20–98
Boehmer (1997) Aspects of lymphocyte developmental biology. Immunology Today, 18(6): 260–262
Lanier LL, Phillips JL (1992) Natural killer cells. Curr Opin Immunol 4(1):38–42
Yabuhara A, Kawai H, Komiyama A (1990) Development of natural killer cytotoxicity during childhood: marked increases in number of natural killer cells with adequate cytotoxic abilities during infancy to early childhood. Pediatr Res 28(4):316–322
Qian JX et al (1997) Decreased interleukin-15 from activated cord versus adult peripheral blood mononuclear cells and the effect of interleukin-15 in upregulating antitumor immune activity and cytokine production in cord blood. Blood 90(8): 3106–3117
Shore SL et al (1977) Antibody-dependent cellular cytotoxicity to target cells infected with herpes simplex viruses: functional adequacy in the neonate. Pediatrics 59(1):22–28
Pabst HF, Kreth HW (1980) Ontogeny of the immune response as a basis of childhood disease. J Pediatr 97(4):519–534
Sancho L et al (1991) Two different maturational stages of natural killer lymphocytes in human newborn infants. J Pediatr 119(3): 446–454
Baley JE, Schacter BZ (1985) Mechanisms of diminished natural killer cell activity in pregnant women and neonates. J Immunol 134(5):3042–3048
Subauste CS, Dawson L, Remington JS (1992) Human lymphokine-activated killer cells are cytotoxic against cells infected with Toxoplasma gondii. J Exp Med 176(6):1511–1519
Dannemann BR et al (1989) Assessment of human natural killer and lymphokine-activated killer cell cytotoxicity against Toxoplasma gondii trophozoites and brain cysts. J Immunol 143(8):2684–2691
Suzuki Y et al (1988) Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 240(4851):516–518
Denkers EY et al (1993) Emergence of NK1.1+ cells as effectors of IFN-gamma dependent immunity to Toxoplasma gondii in MHC class I-deficient mice. J Exp Med 178(5): 1465–1472
Hunter CA et al (1994) Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin- 12, and tumor necrosis factor alpha. Infect Immun 62(7):2818–2824
Hunter CA et al (1997) The role of the CD28B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii. J Immunol 158(5):2285–2293
Beaman MH, Araujo FG, Remington JS (1994) Protective reconstitution of the SCID mouse against reactivation of toxoplasmic encephalitis. J Infect Dis 169(2):375–383
Lindberg RE, Frenkel JK (1977) Toxoplasmosis in nude mice. J Parasitol 63(2):219–221
Hughes HP et al (1988) Absence of a role for natural killer cells in the control of acute infection by Toxoplasma gondii oocysts. Clin Exp Immunol, 72(3):394–399
van Furth R, Raeburn JA, van Zwet TL (1979) Characteristics of human mononuclear phagocytes. Blood 54(2):485–500
Glauser MP et al (1991) Septic shock: pathogenesis [see comments]. Lancet 338(8769): 732–736
Scharton-Kersten TM et al (1996) In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol, 157(9):4045–4054
McDyer JF, Wu CY, Seder RA (1998) The regulation of IL-12: its role in infectious, autoimmune, and allergic diseases. J Allergy Clin Immunol 102(1):11–15
Gazzinelli RT et al (1994) Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 153(6): 2533–2543
Ma X et al (1996) The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med 183(1):147–157
Abbas AK, Lichtman AH, Pober JS (1991) Cellular and Molecular Immunology. Saunders, Philadelphia.
McLeod RJJ, Estes R, Mack D (1996). Toxoplasma gondii. In : Gross U (ed) in Current Topics in Microbiology and Immunology. Springer-Verlag, Berlin Heidelberg, pp. 95112
Roth R, Spiegelberg HL (1996) Activation of cloned human CD4+ Thl and Th2 cells by blood dendritic cells. Scand J Immunol 43(6):646–651
Bhardwaj N et al (1996) IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro. J Clin Invest 98(3):715–722
Bhardwaj N et al (1992) Dendritic cells are potent antigen-presenting cells for microbial superantigens. J Exp Med 175(1):267–273
Cella M et al (1996) Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 184(2):747–752
Kelemen E, Janossa M (1980) Macrophages are the first differentiated blood cells formed in human embryonic liver. Exp Hematol 8(8):996–1000
English BK et al (1992) Decreased granulocyte-macrophage colony-stimulating factor production by human neonatal blood mononuclear cells and T cells. Pediatr Res 31(3): 211–216
Lee SM et al (1996) Decreased interleukin-12 (IL-12) from activated cord versus adult peripheral blood mononuclear cells and upregulation of interferon-gamma, natural killer, and lymphokine-activated killer activity by IL-12 in cord blood mononuclear cells. Blood 88(3):945–954
Christensen RD (1989) Hematopoiesis in the fetus and neonate. Pediatr Res 26(6):531–535
Speer CP et al (1985) Oxidative metabolism in cord blood monocytes and monocyte-derived macrophages. Infect Immun 50(3):919–921
Conly ME, Speert DP (1991) Human neonatal monocyte-derived macrophages and neutrophils exhibit normal nonopsonic and opsonic receptor-mediated phagocytosis and superoxide anion production. Biol Neonate 60(6):361–366
Wilson CB, Haas JE (1984) Cellular defenses against Toxoplasma gondii in newborns. J Clin Invest 73(6):1606–1616
Lin RY (1996) The role of the fetal fibroblast and transforming growth factor-beta in a model of human fetal wound repair. Semin Pediatr Surg 3:165–174
Seguin R, Kasper LH (1999) Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii [In Process Citation]. J Infect Dis 179(2):467–474
Ridge JP, Di Rosa F, Matzinger P (1998) A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell [see comments]. Nature 393(6684): 474–478
Schoenberger SP et al (1998) T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions [see comments]. Nature 393(6684):480–483
DeKruyff RH, Gieni RS, Umetsu DT (1997) Antigen-driven but not lipopolysaccharidedriven IL-12 production in macrophages requires triggering of CD40. J Immunol 158(1):359–366
Sousa CR et al (1997) In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas [see comments]. J Exp Med 186(11):1819–1829
Sorg RV, K.G.a.P.W. (1998) Functional competence of Dendritic Cells in human umbilical cord blood. Bone Marrow Transplantation 22(Suppl 1.):552–554
Denkers EY, Gazzinelli RT (1998) Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 11(4):569–588
Johnson LL (1992) SCID mouse models of acute and relapsing chronic Toxoplasma gondii infections. Infect Immun 60(9):3719–3724
Hunter CA et al (1995) Studies on the role of interleukin-12 in acute murine toxoplasmosis. Immunology 84(1):16–20
Johnson LL (1992) A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection. Infect Immun 60(5):1979–1983
Gazzinelli RT et al (1993) Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts [see comments]. Proc Natl Acad Sci USA, 90(13):6115–6119
Chang HR, Grau GE, Pechere JC (1990), Role of TNF and IL-1 in infections with Toxoplasma gondii. Immunology 69(1):33–37
Scharton-Kersten T et al (1997) Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med 186(9):1523–1534
Channon JY, Kasper LH (1996) Toxoplasma gondii-induced immune suppression by human peripheral blood monocytes: role of gamma interferon. Infect Immun 64(4):1181–1189
McLeod R et al (1980) Effects of human peripheral blood monocytes, monocyte-derived macrophages, and spleen mononuclear phagocytes on Toxoplasma gondii. Cell Immunol 54(2):330–350
Subauste CS, de Waal Malefyt R, Fuh F (1998) Role of CD80 (B7.1) and CD86 (B7.2) in the immune response to an intracellular pathogen. J Immunol 160(4):1831–1840
Moore KW et al (1993) Interleukin-10. Annu Rev Immunol 11:165–190
Gazzinelli RT et al (1992) IL-10 inhibits parasite killing and nitrogen oxide production by IFN- gamma-activated macrophages. J Immunol 148(6):1792–1796
Gazzinelli RT et al (1996) In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4- T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 157(2):798–805
Neyer LE et al (1997) Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii. Infect Immun 65(5): 1675–1682
Oswald IP et al (1992) IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J Immunol 148(11):3578–3582
Roberts CW et al (1996) Different roles for interleukin-4 during the course of Toxoplasma gondii infection. Infect Immun 64(3):897–904
Bermudez LE, Covaro G, Remington J (1993) Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors. Infect Immun 61(10): 4126–4130
Luder CG et al (1998) Down-regulation of MHC class II molecules and inability to up-regulate class I molecules in murine macrophages after infection with Toxoplasma gondii. Clin Exp Immunol 112(2):308–316
McLeod R et al (1989) Genetic regulation of early survival and cyst number after per-oral Toxoplasma gondii infection of A x B/B x A recombinant inbred and B10 congenic mice. J Immunol 143(9):3031–3034
Blackwell JM, Roberts CS, Roach TI, Alexander J (1994) Influence of macrophage resistance gene Lsh/S/Ity/Bcg (candidate NRamp on Toxoplasma gondii infection in mice). Clin Exp Immunol 97:107–112
Capron M et al (1997) Differentiation of eosinophils from cord blood cell precursors: kinetics of Fc epsilon RI and Fc epsilon RII expression. Int Arch Allergy Immunol 113(1–3):48–50
Lewis RA, Austen KF, Soberman RJ (1990) Leukotrienes and other products of the 5lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 323(10):645–655
Huber AR et al (1991) Regulation of transendothelial neutrophil migration by endogenous interleukin-8 [published errata appear in Science 1991 Nov 1:254(5032):631 and 1991 Dec 6:254(5037):1435]. Science 254(5028):99–102
Erdman SH et al (1982) Supply and release of storage neutrophils. A developmental study. Biol Neonate, 41(3–4):132–137
Anderson DC et aÃ.(1991) Diminished lectin-, epidermal growth factor-, complement binding domain-cell adhesion molecule-1 on neonatal neutrophils underlies their impaired CD18-independent adhesion to endothelial cells in vitro. J Immunol 146(10): 3372–3379
Anderson DC et al (1984) Impaired motility of neonatal PMN leukocytes: relationship to abnormalities of cell orientation and assembly of microtubules in chemotactic gradients. J Leukoc Biol 36(1):1–15
Hill HR (1987) Biochemical, structural, and functional abnormalities of polymorphonuclear leukocytes in the neonate. Pediatr Res 22(4):375–382
Klein RB et al (1977) Decreased mononuclear and polymorphonuclear chemotaxis in human newborns, infants, and young children. Pediatrics, 60(4):467–472
Newburger PE (1982) Superoxide generation by human fetal granulocytes. Pediatr Res, 16(5):373–376.
Ambruso DR et al (1984) Oxidative metabolism of cord blood neutrophils: relationship to content and degranulation of cytoplasmic granules. Pediatr Res 18(11):1148–1153
Marshall AJ, Denkers EY (1998) Toxoplasma gondii triggers granulocyte-dependent cytokine-mediated lethal shock in D-galactosamine-sensitized mice. Infect Immun, 66(4):1325–1333
Saito H et al (1988) Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins. Proc Natl Acad Sci USA, 85(7):2288–2292
Khalife J et al (1986) Role of specific IgE antibodies in peroxidase (EPO) release from human eosinophils. J Immunol 137(5):1659–1664
Forestier F et al (1986) Hematological values of 163 normal fetuses between 18 and 30weeks of gestation. Pediatr Res, 20(4):342–346
Ridel PR et al (1988) Protective role of IgE in immunocompromised rat toxoplasmosis. J Immunol 141(3):978–983
Brown CR et al (1995) Definitive identification of a gene that confers resistance against Toxoplasma cyst burden and encephalitis. Immunology 85(3):419–428
Stanley K, Luzio P (1988) Perforin. A family of killer proteins [news]. Nature 334(6182): 475–476
Masson D, Tschopp J (1987) A family of serine esterases in lytic granules of cytolytic T lymphocytes. Cell 49(5):679–685
Roberts MD (1999) Thesis Department of Pathology, Glasgow
Romagnani S (1996) Thl and Th2 in human diseases. Clin Immunol 80(3 Pt 1):225–235
Gimmi CD et al (1991) B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci USA, 88(15): 6575–6579.
Freeman GJ et al (1993) Murine B7–2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production. J Exp Med 178(6):2185–2192
Linsley PS, Ledbetter JA (1993) The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 11:191–212
Kubin M, Kamoun M, Trinchieri G (1994) Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp Med 180(1):211–222
Schwartz RH (1990) A cell culture model for T lymphocyte clonal anergy. Science, 248(4961):1349–1356
Schwartz RH (1992) Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71(7):1065–1068
Mackay CR (1993) Immunological memory. Adv Immunol 53:217–265
Vaux DL, Strasser A (1996) The molecular biology of apoptosis. Proc Natl Acad Sci USA, 93(6):2239–2244
Haynes BF et al (1988) Analysis of expression of CD2, CD3, and T cell antigen receptor molecules during early human fetal thymic development [published erratum appears in J Immunol 1989 Feb 15:142(4):1410]. J Immunol 141(11):3776–3784
Davis MM (1988) Molecular genetics of T-cell antigen receptors. Hosp Pract (Off Ed) 23(5):157–164, 169–170
Schild H et al (1994) The nature of major histocompatibility complex recognition by gamma delta T cells. Cell 76(1):29–37
George JF Jr, Schroeder HW Jr (1992) Developmental regulation of D beta reading frame and junctional diversity in T cell receptor-beta transcripts from human thymus. J Immunol 148(4):1230–1239
Blackman M, Kappler J, Marrack P (1990) The role of the T cell receptor in positive and negative selection of developing T cells. Science 248(4961):1335–1341
Alam SM et al (1996) T-cell-receptor affinity and thymocyte positive selection [see comments]. Nature 381(6583):616–620
Robey EA et al (1992) The level of CD8 expression can determine the outcome of thymic selection. Cell 69(7):1089–1096
Nossal GJ (1994) Negative selection of lymphocytes. Cell 76(2):229–239
Kisielow P et al (1988) Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 333(6175):742–746
Kappler JW et al (1988) Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332(6159):35–40
von Boehmer H, Teh HS, Kisielow P (1989) The thymus selects the useful, neglects the useless and destroys the harmful. Immunol Today 10(2):57–61
Asma GE, Van den Bergh RL, Vossen JM (1983) Use of monoclonal antibodies in a study of the development of T lymphocytes in the human fetus. Clin Exp Immunol, 53(2):429–436
Erkeller-Yuksel FM et al (1992) Age-related changes in human blood lymphocyte sub-populations. J Pediatr 120(2 Pt 1):216–222
De Paoli P, Battistin S, Santini GF (1988) Age-related changes in human lymphocyte subsets: progressive reduction of the CD4 CD45R (suppressor inducer) population. Clin Immunol Immunopathol 48(3):290–296
Azuma M et al (1993) Requirements for CD28-dependent T cell-mediated cytotoxicity. J Immunol 150(6):2091–2101
Rayfield LS, Brent L, Rodeck CH (1980) Development of cell-mediated lympholysis in human foetal blood lymphocytes. Clin Exp Immunol 42(3):561–570
Oliver AM et al (1989) The distribution and differential expression of MHC class II antigens (HLA-DR, DP, and DQ) in human fetal adrenal, pancreas, thyroid, and gut. Transplant Proc, 21(1 Pt 1):651–652
Harvey JE, Jones DB (1990) Distribution of LCA protein subspecies and the cellular adhesion molecules LFA-1, ICAM-1 and p150,95 within human foetal thymus. Immunology 70(2):203–209
Khalili H, DR, Chang MY (1997) The defective antigen-presenting activity of murine fetal macrophage cell lines. Immunology 4:487–493
Hayward AR, Kurnick J (1981) Newborn T cell suppression: early appearance, maintenance in culture, and lack of growth factor suppression. J Immunol 126(1):50–53
Wilson CB et al (1986) Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies. J Clin Invest 77(3):860–867
Pirenne H et al (1992) Comparison of T cell functional changes during childhood with the ontogeny of CDw29 and CD45RA expression on CD4+ T cells. Pediatr Res 32(1): 81–86
Lewis DB et al (1991) Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells. J Clin Invest 87(1):194–202
D’Andrea A et al (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon-gamma production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 178(3):1041–1048
Kos FJ, Engleman EG (1996) Immune regulation: a critical link between NK cells and CTLs. Immunol Today 17(4):174–176
Gazzinelli R et al (1992) Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol 149(1): 175–180
Gazzinelli RT et al (1991) Synergistic role of CD4+ and CD8+ T lymphocytes in IFNgamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 146(1):286–292
Trinchieri G (1993) Interleukin-12 and its role in the generation of TH1 cells. Immunol Today 14(7):335–338
Montoya JG et al (1996) Human CD4+ and CD8+ T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells. Infect Immun 64(1):176–181
Brown C, ER, McLeod R (1995) Fate of an intracellular parasite during lysis of its host cell by CD8+ lymphocytes. Keystone meeting, Keystone, CO
Nash PB et al (1998) Toxoplasma gondii-infected cells are resistant to multiple inducers of apoptosis. J Immunol 160(4):1824–1830
Huldt (1973) Effect of Toxoplasma gondii on the thymus. Nature 244(5413): 301–303
McLeod R et al (1984) Immune response of mice to ingested Toxoplasma gondii: a model of toxoplasma infection acquired by ingestion. J Infect Dis 149(2):234–244
Hohfeld PF, Marion S, Thulliez P, Marcon P, Daffos F (1990) Toxoplasma gondii infection during pregnancy: T lymphocyte subpopulations in mothers and fetuses. Pedatr Infect Dis J 9:878–881
Lecolier B et al (1989) T-cell subpopulations of fetuses infected by Toxoplasma gondii [letter]. Eur J Clin Microbiol Infect Dis 8(6):572–573
Foulon W et al (1990) Detection of congenital toxoplasmosis by chorionic villus sampling and early amniocentesis. Am J Obstet Gynecol 163(5 Pt 1):1511–1513
Subauste CS et al (1998) Alpha beta T cell response to Toxoplasma gondii in previously unexposed individuals. J Immunol 160(7):3403–3411
McLeod R et al (1990) Phenotypes and functions of lymphocytes in congenital toxoplasmosis. J Lab Clin Med 116(5):623–635
Hara T et al (1996) Human V delta 2+ gamma delta T-cell tolerance to foreign antigens of Toxoplasma gondii. Proc Natl Acad Sci USA, 93(10):5136–5140
Mack DM, Holfels E, McLeod R (1999) Immune Responses in human congenital toxoplasmosis. (in preparation).
Raymond J et al (1990) Presence of gamma interferon in human acute and congenital toxoplasmosis [published erratum appears in J Clin Microbiol 1990 28(12):2853]. J Clin Microbiol 28(6):1434–1437
Alexander J et al (1998) The role of IL-4 in adult acquired and congenital toxoplasmosis. Int J Parasitol 28(1):113–120
Wegmann TG et al (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? [see comments]. Immunol Today 14(7):353–356
Alexander J et al (1997) Mechanisms of innate resistance to Toxoplasma gondii infection. Philos Trans R Soc Lond B Biol Sci 352(1359):1355–1359
Piccinni MP et al (1995) Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Thl cell clones. J Immunol 155(1):128–133
Gazzinelli RT, Denkers EY, Sher A (1993) Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites. Infect Agents Dis 2(3):139–149
Suzuki Y, Remington JS (1990) The effect of anti-IFN-gamma antibody on the protective effect of Lyt- 2+ immune T cells against toxoplasmosis in mice. J Immunol 144(5): 1954–1956
Yano A et al (1989) Antigen presentation by Toxoplasma gondii-infected cells to CD4+ proliferative T cells and CD8+ cytotoxic cells. J Parasitol 75(3):411–416
Parker SJ, Roberts CW, Alexander J (1991) CD8+ T cells are the major lymphocyte sub-population involved in the protective immune response to Toxoplasma gondii in mice. Clin Exp Immunol 84(2):207–212
Purner MB et al (1996) CD4-mediated and CD8-mediated cytotoxic and proliferative immune responses to Toxoplasma gondii in seropositive humans. Infect Immun 64(10): 4330–4338
Black CM et al (1989) Effect of recombinant tumour necrosis factor on acute infection in mice with Toxoplasma gondii or Trypanosoma cruzi. Immunology 68(4):570–574
Sullender WM et al (1987) Humoral and cell-mediated immunity in neonates with herpes simplex virus infection [published erratum appears in J Infect Dis 155(4):838]. J Infect Dis 155(1):28–37
Gehrz RC et al (1987) HLA class II restriction of T helper cell response to cytomegalovirus (CMV). I. Immunogenetic control of restriction. J Immunol 138(10):3145–3151
Lang T et al (1994) Leishmania donovani-infected macrophages: characterization of the parasitophorous vacuole and potential role of this organelle in antigen presentation. J Cell Sci 107(Pt 8):2137–2150
Saha B et al (1994) Macrophage-T cell interaction in experimental mycobacterial infection. Selective regulation of co-stimulatory molecules on Mycobacterium-infected macrophages and its implication in the suppression of cell-mediated immune response. Eur J Immunol 24(11):2618–2624
Himeno K, Hisaeda H (1996) Contribution of 65-kDa heat shock protein induced by gamma and delta T cells to protection against Toxoplasma gondii infection. Immunol Res 15(3):258–264
Moore KJ, Matlashewski G (1994) Intracellular infection by Leishmania donovani inhibits macrophage apoptosis. J Immunol 152(6):2930–2937
Huskinson J et al (1989) Toxoplasma antigens recognized by immunoglobulin G subclasses during acute and chronic infection. J Clin Microbiol 27(9):2031–2038
Noelle RJ, Ledbetter JA, Aruffo A (1992) CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation. Immunol Today 13(11):431–433
Clark EA, Lane PJ (1991) Regulation of human B-cell activation and adhesion. Annu Rev Immunol 9:97–127
Gathings WE, Lawton AR, Cooper MD (1977) Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans. Eur J Immunol 7(11):804–810
Yellen AJ et al (1991) Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice. J Immunol 146(5):1446–1454
DeBiagi M, Andreani M, Centis F (1985) Immune characterization of human fetal tissues with monoclonal antibodies. Prog Clin Biol Res 193:89–94
Kohler PF, Farr RS (1966) Elevation of cord over maternal IgG immunoglobulin: evidence for an active placental IgG transport. Nature 210(40):1070–1071
Burgio GR et al (1980) Ontogeny of secretory immunity: levels of secretory IgA and natural antibodies in saliva. Pediatr Res 14(10):1111–1114
Andersson U et al (1981) Humoral and cellular immunity in humans studied at the cell level from birth to two years of age. Immunol Rev 57:1–38
Splawski JB, Lipsky PE (1991) Cytokine regulation of immunoglobulin secretion by neonatal lymphocytes. J Clin Invest 88(3):967–977
McLeod R et al (1988) Subcutaneous and intestinal vaccination with tachyzoites of Toxoplasma gondii and acquisition of immunity to peroral and congenital toxoplasma challenge. J Immunol 140(5):1632–1637
Blackwell JM (1998) Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil. Int J Parasitol 28(1):21–28
Roberts F.a.R.M. (1999) Pathogenesis of Toxoplasmic Retinochoroiditis. Parasitology Today 15(2):51–57
Suzuki Y (1997) Cells and cytokines in host defense of the central nervous system. In: Peterson R (ed) In Defense of the Brain, Blackwell Science, Malden, 56–73
Montoya G, Remington JS (1997) Toxoplasmosis of the Central Nervous System. In: Peterson R (ed). In Defense of the Brain. Blackwell Science, Malden, pp. 163–188
Hill AVS, Willis AC, Aidoo M, Allsopp CE, Gotch FM, Gai XM, Takiguchi M, Greenwood BM, Townsend AR (1992) Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360:434–439
McLeod R, Arbuckle D, Skamene E (1995) Immunogenetics in the analysis of resistance to intracellular pathogens. Curr Opin Immunol 7:539–552
Bodner JG, Albert ED, Bodmer WF, Dupont B, Erlich HD, Mach B, Mayr WR, Patnam P, Sasazuld T (1994) Nomenclature report: nomenclature for factors of the HLA system. Tissue Antigens 44:1–18
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McLeod, R., Dowel, M. (2000). Basic immunology: the fetus and the newborn. In: Ambroise-Thomas, P., Petersen, P.E. (eds) Congenital toxoplasmosis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0847-5_4
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DOI: https://doi.org/10.1007/978-2-8178-0847-5_4
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