Skip to main content
SpringerLink
Log in

Parathyroid Carcinoma

  • Chapter
  • First Online:
Endocrine Surgery

Part of the book series: Springer Specialist Surgery Series ((SPECIALIST))

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism (PHPT) (<1%) and is usually associated with more severe clinical manifestations than its much more common benign counterpart, the parathyroid adenoma [1–3].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Shane E. Clinical Review 122: parathyroid carcinoma. J Clin Endocrinol Metab. 2001;2:485–93.

    Article  Google Scholar 

  2. De Lellis RA. Parathyroid carcinoma. An overview. Adv Anat Pathol. 2005;12:53–61.

    Article  Google Scholar 

  3. Marcocci C, Cetani F, Ruhin MR, Silverberg SJ, Pinchera A, Biletikian JP. Parathyzoid Carcinoma. J Bone Miner Res 2008; 23:1869–80.

    Google Scholar 

  4. Bondenson L, Grimelius L, DeLellis RA, Lloyd R, Akerstrom G, Larsson C, Arnold A, Eng C, Shane E, Bilezikian JP. Parathyroid carcinoma. In: RA DeLellis, RV Lloyd, PU Heitz, C Eng, editors. Pathology and genetics. Tumours of endocrine organs. WHO Classification of Tumours. Lyon: IARC Press; 2004. 124–27.

    Google Scholar 

  5. Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey-Wilson J, Simonds WF, Gillanders EM, Kennedy AM, Chen JD, Agarwal SK, Sood R, Jones MP, Moses TY, Haven C, Petillo D, Leotlela PD, Harding B, Cameron D, Pannett AA, Hoog A, Heath H. 3rd, James-Newton LA, Robinson B, Zarbo RJ, Cavaco BM, Wassif W, Perrier ND, Rosen IB, Kristoffersson U, Turnpenny PD, Farnebo LO, Besser GM, Jackson CE, Morreau H, Trent JM, Thakker RV, Marx SJ, The BT, Larsson C, Hobbs MR. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumors syndrome. Nat Genet. 2002;32:676–80.

    Google Scholar 

  6. Howell VM, Haven CJ, Kahnoski K, Khoo SK, Petillo D, Chen J, Fleuren GJ, Robinson BG, Delbridge LW, Philips J, Nelson AE, Krause U, Hammje K, Dralle H, Hoang-Vu C, Gimm O, Marsh DJ, Morreau H, The BT. HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours. J Med Genet 2003;40:657–63.

    Article  PubMed  CAS  Google Scholar 

  7. Shattuck TM, Valimaki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD Farnebo LO, Larsson C, Arnold A. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med. 2003;349:1722–29.

    Article  PubMed  CAS  Google Scholar 

  8. Cetani F, Pardi E, Borsari S, Viacava P, Dipollina G, Cianferotti L, Ambrogini E, Gazzerro E, Colussi G, Berti P, Miccoli P, Pinchera A, Marcocci C. Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors. J Clin Endocrinol Metab. 2004;89:5583–91.

    Article  PubMed  CAS  Google Scholar 

  9. Rubin MR, Silverberg SJ. Editorial: HRPT2 in parathyroid cancer: a piece of the puzzle. J Clin Endocrinol Metab. 2005;90:5505–07.

    Article  PubMed  CAS  Google Scholar 

  10. Tan MH, Morrison C, Wang P, Yang X, Haven CJ, Zhang C, Zhao P, Tretiakova MS, Korpi-Hyovalti E, Burgess JR, Soo KC, Cheah WK, Cao B, Resau J, Morreau H, Teh BT. Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroid carcinoma. Clin Cancer Res. 2004;10:6629–37.

    Article  PubMed  CAS  Google Scholar 

  11. Gill AJ, Clarkson A, Gimm O, Keil J, Dralle H, Howell VM, Marsh DJ Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias. Am J Surg Pathol. 2006;30:1140–49.

    PubMed  Google Scholar 

  12. Cetani F, Ambrogini E, Viacava P, et al. Should parafibromin staining replace HRPT2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma? Eur J Endocrinol. 2007;156:547–54.

    Article  PubMed  CAS  Google Scholar 

  13. Juhlin CC, Villablanca A, Sandelin K, et al. Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification. Endocr Relat Cancer. 2007;14:501–12.

    Article  PubMed  CAS  Google Scholar 

  14. Hundahl SA, Fleming ID, Fremgen AM, Menck HR. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985–1999: A National Cancer Database report. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1999;86:538–44.

    Article  PubMed  CAS  Google Scholar 

  15. Favia G, Lumachi F, Polistina F, D’Amico DF. Parathyroid carcinoma: sixteen new cases and suggestions for correct management. World J Surg. 1998;22:1225–30.

    Article  PubMed  CAS  Google Scholar 

  16. Obara T, Fujimoto Y. Diagnosis and treatment of patients with poarathyroid cacrcinoma: An update and review. Word J Surg. 1991;15:738–44.

    Article  CAS  Google Scholar 

  17. Ireland J, Fleming S, Levison D, Cattell W, Baker L. Parathyroid carcinoma associated with chronic renal failure and previous radiotherapy to the neck. J Clin Pathol. 1985;38:1114–18.

    Article  PubMed  CAS  Google Scholar 

  18. Christmas TJ, Chapple CR, Noble JG, Milroy EJ, Cowie AG. Hyperparathyroidism after neck irradiation. Br J Surg. 1988;75:873–74.

    Article  PubMed  CAS  Google Scholar 

  19. Berland Y, Olmer M, Lebreuil G, Grisoli J. Parathyroid carcinoma, adenoma and hyperplasia in a case of chronic renal insufficiency on dialysis. Clin Nephrol. 1982;18:154–58.

    PubMed  CAS  Google Scholar 

  20. Boyle NH, Ogg CS, Hartley RB, Owen WJ. Parathyroid carcimoma secondary to prolonged hyperplasia in chronic renal failure and celiac disease. Eur J Surg Oncol. 1999;25:100–03.

    PubMed  CAS  Google Scholar 

  21. Yoshimoto K, Endo H, Tsuyuguchi M, Tanaka C, Kimura T, Iwahana H, Kato G, Sano T, Itakura Familial isolated primary hyperparathyroidism with parathyroid carcinomas:clinical and molecular features. Clin Endocrinol (Oxf). 1998;48:67–72.

    Article  CAS  Google Scholar 

  22. Dinnen J, Greenwood R, Jone J, Walker D, Williams E. Parathyroid carcinoma in familial hyperparathyroidism. J Clin Pathol. 1977;30:966–75.

    Article  PubMed  CAS  Google Scholar 

  23. Wassif WS, Moniz CF, Friedman E, Wong S, Weber G, Nordenskjöld M, Peters TJ, Larsson C. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab. 1993;77:1485–89.

    Article  PubMed  CAS  Google Scholar 

  24. Streeten EA, Weinstein LS, Norton JA, Mulvihill JJ, White BJ, Friedman E, JaffeG, Brandi ML, Stewart K, Zimering MB, Spiegel AM, Aurbach GD, Marx SJ. Studies in a kindred with parathyroid carcinoma. J Clin Endocrinol Metab. 1992;75:362–66.

    Article  PubMed  CAS  Google Scholar 

  25. Marx SJ, Simonds WF, Agarwal SK, Burns AL, Weinstein LS, Cochran C, Skarulis, MC, Spiegel AM, Libutti SK, Alexander HR Jr, Chen CC, Chang R, Chandrasekharappa, SC, Collins FS. Hyperparathyroidism in hereditary syndromes: special expressions and special managements. J Bone Miner Res. 2002;17(Suppl 2):N37–43.

    PubMed  CAS  Google Scholar 

  26. Chen JD, Morrison C, Zhang C, Kahnoski K, Carpten JD, Teh BT. Hyperparathyroidism-jaw tumour syndrome. J Intern Med. 2003;253:634–42.

    Article  PubMed  CAS  Google Scholar 

  27. Mallette LE, Malini S, Rappaport MP, Kirkland JL. Familial cystic parathyroid adenomatosis. Ann Intern Med. 1987;107:54–60.

    PubMed  CAS  Google Scholar 

  28. Wassif WS, Moniz CF, Friedman E, Wong S, Weber G, Nordenskjöld M, Peters TJ, Larsson C. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab. 1993;77:1485–89.

    Article  PubMed  CAS  Google Scholar 

  29. Simonds WF, James-Newton LA, Agarwal SK, Yang B, Skarulis MC, Hendy GN, Marx SJ. Familial isolated hyperparathyroidism: clinical and genetic characteristics of 36kindreds. Medicine (Baltimore). 2002;81:1–26.

    Article  Google Scholar 

  30. Dionisi S, Minisola S, Pepe J, De Geronimo S, Paglia F, Memeo L, Fitzpatrick LA. Concurrent parathyroid adenomas and carcinoma in the setting of multiple endocrine neoplasia type 1: presentation as hypercalcemic crisis. Mayo Clin Proc. 2002;77:866–69.

    Article  PubMed  Google Scholar 

  31. Haven CJ, van Puijenbroek M, Tan MH, Teh BT, Fleuren GJ, van Wezel T, Morreau H. Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas. Clin Endocrinol (Oxf). 2007;67:370–76.

    Article  CAS  Google Scholar 

  32. Jenkins PJ, Satta MA, Simmgen M, Drake WM, Williamson C, Lowe DG, Britton K, Chew SL, Thakker RV, Besser GM. Metastatic parathyroid carcinoma in the MEN2A syndrome. Clin Endocrinol (Oxf). 1997;47:747–51.

    Article  CAS  Google Scholar 

  33. Cryns VL, Thor A, Xu HJ, Hu SX, Wierman ME, Vickery AL Jr, Benedict WF, Arnold A. Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med. 1994; 330:757–61.

    Article  PubMed  CAS  Google Scholar 

  34. Dotzenrath C, The T, Farnebo F, Cupisti K, Svensson A, Toell A, Goretzki P, Larsson, C. Allelic loss of the retinoblastoma tumor suppressor gene: a marker for aggressive parathyroid tumors? J Clin Endocrinol Metab. 1996;8:3194–96.

    Article  Google Scholar 

  35. Pearce SH, Trump D, Wooding W, Sheppard MN, Clayton RN, Thakker RV. Loss of heterozygosity study at the retinoblastoma and breast cancer susceptibility (BRCA2) loci in pituitary, parathyroid, pancreatic and carcinoid tumors. Clin Endocrinol (Oxf). 1996;45:195–200.

    Article  CAS  Google Scholar 

  36. Cetani F, Pardi E, Viacava P, Pollina GD, Fanelli G, Picone A, Borsari S, Gazzerro E, Miccoli P, Berti P, Pinchera A, Marcocci C. A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer. Clinical Endocrinology. 2004;60:99–106.

    Article  PubMed  CAS  Google Scholar 

  37. Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti, RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Clin Endocrinol (Oxf). 2003;59:180–89.

    Article  CAS  Google Scholar 

  38. Cryns VL, Rubio MP, Thor AD, Louis DN, Anrold A. p53 abnormalities in human parathyroid carcinoma. J Clin Endocrinol Metab. 1994;78:1320–24.

    Article  PubMed  CAS  Google Scholar 

  39. Vasef MA, Brynes RK, Sturm M, Bromley C, Robinson RA. Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical studies. Mod Pathol 1999;12:412–16.

    PubMed  CAS  Google Scholar 

  40. Cavaco BM, Guerra L, Bradley KJ, Carvalho D, Harding B, Oliveira A, Santos MA, Sobrinho LG, Thakker RV, Leite ,V. Hyperparathyroidism-jaw tumor syndrome in Roma families from Portugal is due to a founder mutation of the HRPT2 gene. J Clin Endocrinol Metab 2004;89:1747–52.

    Article  PubMed  CAS  Google Scholar 

  41. Cetani F, Pardi E, Borsari S, Lemmi M, Ambrogini E, Vignali E, Cianferotti L, Pinchera M. Parathyroid tumorigenesis. Clin Cases Min Bone Metab. 2006;3:123–31.

    Google Scholar 

  42. Simonds WF, Robbins CM, Agarwal SK, Hendy GN, Carpten JD, Marx SJ. Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome. J Clin Endocrinol Metab. 2004 Jan;89:96–102.

    Article  PubMed  CAS  Google Scholar 

  43. Warner J, Epstein M, Sweet A, Singh D, Burgess J, Stranks S, Hill P, Perry-Keene D, Learoyd D, Robinson B, Birdsey P, Mackenzie E, Teh BT, Prins JB, Cardinal J. Genetic testing in familial isolated hyperparathyroidism: unexpected results and their implications. J Med Genet. 2004;41:155–60.

    Article  PubMed  CAS  Google Scholar 

  44. Villablanca A, Calender A, Forsberg L, Höög A, Cheng JD, Petillo D, Bauters C, Kahnoski K, Ebeling T, Salmela P, Richardson AL, Delbridge L, Meyrier A, Proye C, Carpten JD, Teh BT, Robinson BG, Larsson C. Germline and de novo mutations in the HRPT2 tumour suppressor gene in familial isolated hyperparathyroidism (FIHP). J Med Genet. 2004;41:e32.

    Article  PubMed  CAS  Google Scholar 

  45. Bradley KJ, Cavaco BM, Bowl MR, Harding B, Cranston T, Fratter C, Besser GM, Conceição Pereira M, Davie MW, Dudley N, Leite V, Sadler GP, Seller A, Thakker RV. Parafibromin mutations in hereditary hyperparathyroidism syndromes and parathyroid tumours. Clin Endocrinol (Oxf). 2006;64:299–306.

    Article  CAS  Google Scholar 

  46. Mizusawa N, Uchino S, Iwata T, Tsuyuguchi M, Suzuki Y, Mizukoshi T, Yamashita Y, Sakurai A, Suzuki S, Beniko M, Tahara H, Fujisawa M, Kamata N, Fujisawa K, Yashiro T, Nagao D, Golam HM, Sano T, Noguchi S, Yoshimoto K. Genetic analyses in patients with familial isolated hyperparathyroidism and hyperparathyroidism-jaw tumour syndrome. Clin Endocrinol (Oxf). 2006;65:9–16.

    Article  CAS  Google Scholar 

  47. Guarnieri V, Scillitani A, Muscarella LA, Battista C, Bonfitto N, Bisceglia M, Minisola S, Mascia ML, D'Agruma L, Cole DE Diagnosis of parathyroid tumors in familial isolated hyperparathyroidism with HRPT2 mutation: implications for cancer surveillance. J Clin Endocrinol Metab 2006;91:2827–32.

    Article  PubMed  CAS  Google Scholar 

  48. Kelly TG, Shattuck TM, Reyes-Mugica M, Stewart AF, Simonds WF, Udelsman R, Arnold A, Carpenter TO Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation. J Bone Miner Res. 2006;21:1666–71.

    Article  PubMed  CAS  Google Scholar 

  49. Haven CJ, van Puijenbroek M, Tan MH, Teh BT, Fleuren GJ, van Wezel T, Morreau H. Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas. Clin Endocrinol (Oxf). 2007;67:370–6.

    Article  CAS  Google Scholar 

  50. Krebs LJ, Shattuck TM, Arnold A. HRPT2 mutational analysis of typical sporadic parathyroid adenomas. J Clin Endocrinol Metab. 2005;90:5015–17.

    Article  PubMed  CAS  Google Scholar 

  51. Wynne A, Heerden JV, Carney J, Fitzpatrick L. Parathyroid carcinoma: Clincal and pathological features in 43 patients. Medicine. 1992;71:197–205.

    Article  PubMed  CAS  Google Scholar 

  52. Rubin MR, Silverberg SJ, D'Amour P, Brossard JH, Rousseau L, Sliney J Jr, Cantor T, Bilezikian JP. An N-terminal molecular form of parathyroid hormone (PTH) distinct from hPTH(1-84) is overproduced in parathyroid carcinoma. Clin Chem. 2007;53:1470–76.

    Article  PubMed  CAS  Google Scholar 

  53. Stock JL, Weintraub BD, Rosen SW, Aurbach GD, Spiegel AM, Marx SJ. Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism. J Clin Endocrinol Metab. 1982;54:57–63.

    Article  PubMed  CAS  Google Scholar 

  54. Levin KE, Galante M, Clark OH. Parathyroid carcinoma versus parathyroid adenoma in patients with profound hypercalcemia. Surgery. 1987;101:649–60.

    PubMed  CAS  Google Scholar 

  55. Fitzpatrik LA. Acute primary hyperparathyroidism. In: Bilezikian JP, Marcus R, Levine MA, editors. The Parathyroids. Basic and Clinical Concepts, 2nd edition. San Diego: Academic Press; 2001. 527–34.

    Google Scholar 

  56. Wang CA, Gaz RD. Natural history of parathyroid carcinoma. Diagnosis, treatment and results. Am J Surg. 1985,149:522–27.

    Article  PubMed  CAS  Google Scholar 

  57. Shantz A, Castleman B. Parathyroid carcinoma. A study of 70 cases. Cancer. 1973;31:600–05.

    Article  Google Scholar 

  58. De la Garza S, De La Graza E, Batres F. Functional parathyroid carcinoma: Cytology, hiustology and ultrastructure of a case. Diag Cytopathol. 1985;1:232–35.

    Article  Google Scholar 

  59. Holck S, Pedersen N. Carcinoma of the parathyroid gland. A light and electron microscopic study. Acta Pathol Microbiol Scand. 1981;89:297–02.

    CAS  Google Scholar 

  60. Smith J, Coombs R. Histological diagnosis of carcinoma of the parathyroid gland. J Clin Pathol. 1984;37:1370–78.

    Article  PubMed  CAS  Google Scholar 

  61. Jacoby J, Lloyd H, Smith J, Nuclear diameter in parathyroid carcinomas. J Clin Pathol. 1986;39:1353–54.

    Article  Google Scholar 

  62. Abbona GC, Papotti M, Gasparri G, Bussolati G. Proliferative activity in parathyroid tumors as detected by Ki-67 immunostaining. Hum Pathol. 1995;26:135–38.

    Article  PubMed  CAS  Google Scholar 

  63. Farnebo F, Auer G, Farnebo LO, Teh BT, Twigg S, Aspenblad U, Thompson NW, Grimelius L, Larsson C, Sandelin K.Evaluation of retinoblastoma and Ki-67 immunostaining as diagnostic markers of benign and malignant parathyroid disease. World J Surg. 1999;23:68–74.

    Article  PubMed  CAS  Google Scholar 

  64. Lloyd RV, Carney JA, Ferreiro JA, Jin L, Thompson GB, Van Heerden JA, Grant CS, Wollan PC.Immunohistochemical Analysis of the Cell Cycle-Associated Antigens Ki-67 and Retinoblastoma Protein in Parathyroid Carcinomas and Adenomas. Endocr Pathol. 1995;6:279–87.

    Article  PubMed  Google Scholar 

  65. Vargas MP, Vargas HI, Kleiner DE, Merino MJ. The role of prognostic markers (MiB-1, RB, and bcl-2) in the diagnosis of parathyroid tumors. Mod Pathol. 1997;10:12–7.

    PubMed  CAS  Google Scholar 

  66. Naccarato AG, Marcocci C, Miccoli P, Bonadio AG, Cianferotti L, Vignali E, Cipollini G, Viacava P. Bcl-2, p53 and MIB-1 expression in normal and neoplastic parathyroid tissues. J Endocrinol Invest. 1998;21:136–41.

    PubMed  CAS  Google Scholar 

  67. Erickson LA, Jin L, Wollan P, Thompson GB, van Heerden JA, Lloyd RV. Parathyroid hyperplasia, adenomas, and carcinomas: differential expression of p27Kip1 protein. Am J Surg Pathol. 1999;23:288–95.

    Article  PubMed  CAS  Google Scholar 

  68. Haven CJ, van Puijenbroek M, Karperien M, Fleuren GJ, Morreau H. Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma. J Pathol. 2004;2021:86–94.

    Article  Google Scholar 

  69. Bergero N, De Pompa R, Sacerdote C, Gasparri G, Volante M, Bussolati G, Papotti M. Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases. Hum Pathol. 2005 Aug;36(8):908–14.

    Article  Google Scholar 

  70. Adami S, Marcocci C, Gatti D. Epidemiology of primary hyperparathyroidism in Europe. J Bone Miner Res. 2002;17(Suppl 2):N18–23.

    PubMed  Google Scholar 

  71. Wang C, Gaz R Natural history of parathyroid carcinoma: diagnosis, treatment and results. Am J Surg. 1985;149:522–27.

    Article  PubMed  CAS  Google Scholar 

  72. Anderson B, Samaan N, Vassilopoulou-Sellin R, Ordonez N, Hickey R Parathyroid carcinoma: features and difficulties in diagnosis and management. Surgery. 1983;94:906–15.

    PubMed  CAS  Google Scholar 

  73. Koea JB, Shaw JH Parathyroid cancer: biology and management. Surg Oncol. 1999;8:155–65.

    Article  PubMed  CAS  Google Scholar 

  74. Kebebew E. Parathyroid carcinoma. Curr Treat Options Oncol 2001;2:347–54.

    Article  PubMed  CAS  Google Scholar 

  75. Holmes EC, Morton DL, Ketcham AS Parathyroid carcinoma: a collective review. Ann Surg 1969;169:631–40.

    Article  PubMed  Google Scholar 

  76. Johnston LB, Carroll MJ, Britton KE, Lowe DG, Shand W, Besser GM, Grossman AB. The accuracy of parathyroid gland localization in primary hyperparathyroidism using sestamibi radionuclide imaging. J Clin Endocrinol Metab. 1996;81:346–52.

    Article  PubMed  CAS  Google Scholar 

  77. Martinez DA, King DR, Romshe C, Lozano RA, Morris JD, O'Dorisio MS, Martin E Jr. Intraoperative identification of parathyroid gland pathology: a new approach. J Pediatr Surg. 1995;30:1306–09.

    Article  PubMed  CAS  Google Scholar 

  78. Marcocci C, Mazzeo S, Bruno-Bossio G, Picone A, Vignali E, Ciampi M, Viacava P, Naccarato AG, Miccoli P, Iacconi P, Pinchera A. Preoperative localization of suspicious parathyroid adenomas by assay of parathyroid hormone in needle aspirates. Eur J Endocrinol. 1998; 139:72–77.

    Article  PubMed  CAS  Google Scholar 

  79. Spinelli C, Bonadio AG, Berti P, Materazzi G, Miccoli P. Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J Endocrinol Invest. 2000;23:255–57.

    PubMed  CAS  Google Scholar 

  80. Rao SR, Shaha AR, Singh B, Rinaldo A, Ferito A Management of cancer of the parathyroid. Acta Otolaryngol. 2002;122:448–52.

    Article  PubMed  Google Scholar 

  81. Munson ND, Foote RL, Northcutt RC, Tiegs RD, Fitzpatrick LA, Grant CS, van Heerden JA, Thompson GB, Lloyd RV. Parathyroid carcinoma: is there a role for adjuvant radiation therapy? Cancer. 2003;98:2378–84.

    Article  PubMed  Google Scholar 

  82. Clayman GL, Gonzalez HE, El-Naggar A, Vassilopoulou-Sellin R. Parathyroid carcinoma: evaluation and interdisciplinary management. Cancer. 2004;100:900–05.

    Article  PubMed  Google Scholar 

  83. Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, Asper JA, Diaz EM Jr, Evans DB, Gagel RF, Garden A, Hoff AO, Lee JE, Morrison WH, Rosenthal DI, Sherman SI, Sturgis EM, Waguespack SG, Weber RS, Wirfel K, Vassilopoulou-Sellin R Parathyroid carcinoma: a 22-year experience. Head Neck. 2004;26:716–26.

    Article  PubMed  Google Scholar 

  84. Mulder JE, Bilezikian JB Acute management of hypercalcemia. In: Bilezikian JP, Marcus R, Levine MA, editors. The Parathyroids. Basic and Clinical Concepts, 2nd edition. San Diego: Academic Press; 2001. 729–41.

    Google Scholar 

  85. Glover DJ, Shaw L, Glick JH, Slatoplosky E, Weiler C, Attie M, Goldfarb S. Treatment of hyperpcalcemia in parathyroid cancer with WR27-21 S-2-(3-aminopropylamnino)ethyl-phosphorothioic acid. Ann Int Med. 1985;130:55–57.

    Google Scholar 

  86. Koyano H, Shishiba Y, Shimizu T, Suzuki N, Nakazawa H, Tachibana S, Murata H, Furui S. Successful treatment by surgical removal of bone metastasis producing PTH: new approach to the management of metastatic parathyroid carcinoma. Intern Med. 1994;33:697–702.

    Article  PubMed  CAS  Google Scholar 

  87. Denney AM, Watts NB. The effect of octreotide on parathyroid carcinoma. J Clin Endocrinol Metab. 2004;89:1016.

    Article  PubMed  CAS  Google Scholar 

  88. Nemeth EF, Steffey ME, Hammerland LG, Hung BC, Van Wagenen BC, DelMar EG, Balandrin MF. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Natl Acad Sci USA. 1998;95:4040–45.

    Article  PubMed  CAS  Google Scholar 

  89. Collins MT, Skarulis MC, Bilezikian JP, Silverberg SJ, Spiegel AM, Marx SJ. Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent. J Clin Endocrinol Metab. 1998;93:1083–88.

    Article  Google Scholar 

  90. Peacock M, Bilezikian JP, Klassen PS, Guo MD, Turner SA, Shoback D. Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2005;90:135–41.

    Article  PubMed  CAS  Google Scholar 

  91. Silverberg SJ, Rubin MR, Faiman C, Peacock M, Shoback DM, Smallridge RC, Schwanauer LE, Olson KA, Klassen P, Bilezikian JP. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. J Clin Endocrinol Metab. 2007;92:3803–08.

    Article  PubMed  CAS  Google Scholar 

  92. Bradwell AR, Harvey TC. Control of hypercalcaemia of parathyroid carcinoma by immunisation. Lancet. 1999;353:370–73.

    Article  PubMed  CAS  Google Scholar 

  93. Betea D, Bradwell AR, Harvey TC, Mead GP, Schmidt-Gayk H, Ghaye B, Daly AF, Beckers A. Hormonal and biochemical normalization and tumor shrinkage induced by anti-parathyroid hormone immunotherapy in a patient with metastatic parathyroid carcinoma. J Clin Endocrinol Metab. 2004;89:3413–20.

    Article  PubMed  CAS  Google Scholar 

  94. Shoback DM, Arends RH, Roskos L, Shetty S, Wyres M, Huang S, Raienbell GM. Treatment of parathyroid carcinoma with ABX10241, a monoclonal antibody to parathyroid hormone. J Bone Min Res. 2004;17(suppl 1):SA498 (abstract).

    Google Scholar 

  95. Schott M, Feldkamp J, Schattenberg D, Krueger T, Dotzenrath C, Seissler J, Scherbaum WA. Induction of cellular immunity in a parathyroid carcinoma treated with tumor lysate-pulsed dendritic cells Eur J Endocrinol. 2000;142:300–06.

    Article  PubMed  CAS  Google Scholar 

  96. Lee PK, Jarosek SL, Virnig BA, Evasovich M, Tuttle TM. Trends in the incidence and treatment of parathyroid cancer in the United States. Cancer. 2007;109:1736–41.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

    Claudio Marcocci MD

  2. Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy

    Filomena Cetani MD

  3. Department of Medicine, College of Physicians and Surgeons Columbia University, New York, USA

    John P. Bilezikian MD

Authors
  1. Claudio Marcocci MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Filomena Cetani MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. John P. Bilezikian MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, United Kingdom

    Johnathan Hubbard

  2. Coll Physicians & Surgeons Columbia, Fort Washington Avenue 161, New York, 10032, U.S.A.

    William B. Inabnet

  3. Queen Mary Hospital, University of Hong Kong Medical Centre, Pokfulam, Hong Kong, China, People's Republic

    Chung-Yau Lo

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag London Limited

About this chapter

Cite this chapter

Marcocci, C., Cetani, F., Bilezikian, J.P. (2009). Parathyroid Carcinoma. In: Hubbard, J., Inabnet, W., Lo, CY. (eds) Endocrine Surgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-84628-881-4_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-84628-881-4_23

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84628-880-7

  • Online ISBN: 978-1-84628-881-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation