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Route of Delivery, Cell Retention, and Efficiency of Polymeric Microcapsules in Cellular Cardiomyoplasty

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Cellular Cardiomyoplasty

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1036))

Abstract

Stem cell transplantation has been considered as a major breakthrough for treating ischemic heart disease. However, survival and retention of transplanted cells at the site of infarction remains tenuous. This chapter details a method of creating polymeric microcapsules for cell delivery, resulting in increased retention of transplanted cells at the target site, while achieving minimal mechanical trauma and cell loss. Simultaneously biocompatible and biodegradable, polymeric microcapsules have important implications in regenerative cell therapy.

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Acknowledgments

This work is supported in part by research grant (to D Shum-Tim and S Prakash) from Natural Sciences and Engineering Research Council, Canada. A Paul acknowledges postdoctoral award from Fonds Québécois de la Recherche sur la Nature et les Technologies (FRSQ, Canada).

Author information

Authors and Affiliations

  1. Division of Cardiac Surgery, Department of Surgery, McGill University Health Center, McGill University, Montreal, QC, Canada

    Alice Le Huu

  2. Division of Surgical Research, Department of Surgery, McGill University Health Center, McGill University, Montreal, QC, Canada

    Alice Le Huu

  3. Department of Biomedical Engineering, Biomedical Technology and Cell Therapy Research Laboratory, Artificial Cells and Organs Research Centre, McGill University, Montreal, QC, Canada

    Arghya Paul & Satya Prakash

  4. Department of Surgery, Division of Cardiac Surgery, McGill University Health Center, McGill University, Montreal, QC, Canada

    Dominique Shum-Tim

  5. Department of Surgery, Division of Surgical Research, McGill University Health Center, McGill University, Montreal, QC, Canada

    Dominique Shum-Tim

Authors
  1. Alice Le Huu
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  2. Arghya Paul
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  3. Satya Prakash
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  4. Dominique Shum-Tim
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Editor information

Editors and Affiliations

  1. , Department of Surgery, East Tennessee State University, Johnson City, 37614, Tennessee, USA

    Race L. Kao

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Huu, A.L., Paul, A., Prakash, S., Shum-Tim, D. (2013). Route of Delivery, Cell Retention, and Efficiency of Polymeric Microcapsules in Cellular Cardiomyoplasty. In: Kao, R. (eds) Cellular Cardiomyoplasty. Methods in Molecular Biology, vol 1036. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-511-8_11

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  • DOI: https://doi.org/10.1007/978-1-62703-511-8_11

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-510-1

  • Online ISBN: 978-1-62703-511-8

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