Skip to main content

Practical Use of BiNoM: A Biological Network Manager Software

  • Protocol
  • First Online:
In Silico Systems Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1021))

Abstract

The Biological Network Manager (BiNoM) is a software tool for the manipulation and analysis of biological networks. It facilitates the import and conversion of a set of well-established systems biology file formats. It also provides a large set of graph-based algorithms that allow users to analyze and extract relevant subnetworks from large molecular maps. It has been successfully used in several projects related to the analysis of large and complex biological data, or networks from databases. In this tutorial, we present a detailed and practical case study of how to use BiNoM to analyze biological networks.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Brazma A, Krestyaninova M, Sarkans U (2006) Standards for systems biology. Nat Rev Genet 7(8):593–605. doi:nrg1922[pii]10.1038/nrg1922

    Article  PubMed  CAS  Google Scholar 

  2. Klipp E, Liebermeister W, Helbig A, Kowald A, Schaber J (2007) Systems biology standards–the community speaks. Nat Biotechnol 25(4):390–391. doi:nbt0407-390[pii]10.1038/nbt0407-390

    Article  PubMed  CAS  Google Scholar 

  3. Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, Arkin AP, Bornstein BJ, Bray D, Cornish-Bowden A, Cuellar AA, Dronov S, Gilles ED, Ginkel M, Gor V, Goryanin II, Hedley WJ, Hodgman TC, Hofmeyr JH, Hunter PJ, Juty NS, Kasberger JL, Kremling A, Kummer U, Le Novere N, Loew LM, Lucio D, Mendes P, Minch E, Mjolsness ED, Nakayama Y, Nelson MR, Nielsen PF, Sakurada T, Schaff JC, Shapiro BE, Shimizu TS, Spence HD, Stelling J, Takahashi K, Tomita M, Wagner J, Wang J (2003) The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19(4):524–531

    Article  PubMed  CAS  Google Scholar 

  4. Demir E, Cary MP, Paley S, Fukuda K, Lemer C, Vastrik I, Wu G, D’Eustachio P, Schaefer C, Luciano J, Schacherer F, Martinez-Flores I, Hu Z, Jimenez-Jacinto V, Joshi-Tope G, Kandasamy K, Lopez-Fuentes AC, Mi H, Pichler E, Rodchenkov I, Splendiani A, Tkachev S, Zucker J, Gopinath G, Rajasimha H, Ramakrishnan R, Shah I, Syed M, Anwar N, Babur O, Blinov M, Brauner E, Corwin D, Donaldson S, Gibbons F, Goldberg R, Hornbeck P, Luna A, Murray-Rust P, Neumann E, Reubenacker O, Samwald M, van Iersel M, Wimalaratne S, Allen K, Braun B, Whirl-Carrillo M, Cheung KH, Dahlquist K, Finney A, Gillespie M, Glass E, Gong L, Haw R, Honig M, Hubaut O, Kane D, Krupa S, Kutmon M, Leonard J, Marks D, Merberg D, Petri V, Pico A, Ravenscroft D, Ren L, Shah N, Sunshine M, Tang R, Whaley R, Letovksy S, Buetow KH, Rzhetsky A, Schachter V, Sobral BS, Dogrusoz U, McWeeney S, Aladjem M, Birney E, Collado-Vides J, Goto S, Hucka M, Le Novere N, Maltsev N, Pandey A, Thomas P, Wingender E, Karp PD, Sander C, Bader GD (2010) The BioPAX community standard for pathway data sharing. Nat Biotechnol 28(9):935–942. doi:nbt.1666[pii]10.1038/nbt.1666

    Article  PubMed  CAS  Google Scholar 

  5. Le Novere N, Hucka M, Mi H, Moodie S, Schreiber F, Sorokin A, Demir E, Wegner K, Aladjem MI, Wimalaratne SM, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villeger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman TC, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, Watterson S, Wu G, Goryanin I, Kell DB, Sander C, Sauro H, Snoep JL, Kohn K, Kitano H (2009) The systems biology graphical notation. Nat Biotechnol 27(8):735–741. doi:nbt.1558[pii]10.1038/nbt.1558

    Article  PubMed  Google Scholar 

  6. Joshi-Tope G, Gillespie M, Vastrik I, D'Eustachio P, Schmidt E, de Bono B, Jassal B, Gopinath GR, Wu GR, Matthews L, Lewis S, Birney E, Stein L (2005) Reactome: a knowledgebase of biological pathways. Nucleic Acids Res 33(Database issue):D428–D432. doi:33/suppl_1/D428[pii]10.1093/nar/gki072

    Article  PubMed  CAS  Google Scholar 

  7. Le Novere N, Bornstein B, Broicher A, Courtot M, Donizelli M, Dharuri H, Li L, Sauro H, Schilstra M, Shapiro B, Snoep JL, Hucka M (2006) BioModels database: a free, centralized database of curated, published, quantitative kinetic models of biochemical and cellular systems. Nucleic Acids Res 34(Database issue):D689–D691. doi:34/suppl_1/D689[pii]10.1093/nar/gkj092

    Article  PubMed  Google Scholar 

  8. Licata L, Briganti L, Peluso D, Perfetto L, Iannuccelli M, Galeota E, Sacco F, Palma A, Nardozza AP, Santonico E, Castagnoli L, Cesareni G (2012) MINT, the molecular interaction database: 2012 update. Nucleic Acids Res 40(Database issue):D857–D861. doi:gkr930[pii]10.1093/nar/gkr930

    Article  PubMed  CAS  Google Scholar 

  9. Funahashi A, Morohashi M, Kitano H (2003) Cell Designer: a process diagram editor for gene-regulatory and biochemical networks. Biosilico 1(5):159–162

    Article  Google Scholar 

  10. Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T, Bader GD (2007) Integration of biological networks and gene expression data using Cytoscape. Nat Protoc 2(10):2366–2382. doi:nprot.2007.324[pii]10.1038/nprot.2007.324

    Article  PubMed  CAS  Google Scholar 

  11. Zinovyev A, Viara E, Calzone L, Barillot E (2008) BiNoM: a Cytoscape plugin for manipulating and analyzing biological networks. Bioinformatics 24(6):876–877. doi:btm553[pii]10.1093/bioinformatics/btm553

    Article  PubMed  CAS  Google Scholar 

  12. Calzone L, Gelay A, Zinovyev A, Radvanyi F, Barillot E (2008) A comprehensive modular map of molecular interactions in RB/E2F pathway. Mol Syst Biol 4:173. doi:msb20087[pii]10.1038/msb.2008.7

    Article  PubMed  Google Scholar 

  13. Novak B, Csikasz-Nagy A, Gyorffy B, Nasmyth K, Tyson JJ (1998) Model scenarios for evolution of the eukaryotic cell cycle. Philos Trans R Soc Lond B Biol Sci 353(1378):2063–2076. doi:10.1098/rstb.1998.0352

    Article  PubMed  CAS  Google Scholar 

  14. Gonzalez AG, Naldi A, Sanchez L, Thieffry D, Chaouiya C (2006) GINsim: a software suite for the qualitative modelling, simulation and analysis of regulatory networks. Biosystems 84(2):91–100. doi:S0303-2647(05)00169-3[pii]10.1016/j.biosystems.2005.10.003

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

EB, LC, DR, GS, EmB, and AZ are members of the team “Computational Systems Biology of Cancer,” Equipe labellisée par la Ligue Nationale Contre le Cancer. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) ASSET project under agreement number FP7-HEALTH-2010-259348 and from the grant “Projet Incitatif et Collaboratif Computational Systems Biology Approach for Cancer” from Institut Curie.

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media, LLC

About this protocol

Cite this protocol

Bonnet, E., Calzone, L., Rovera, D., Stoll, G., Barillot, E., Zinovyev, A. (2013). Practical Use of BiNoM: A Biological Network Manager Software. In: Schneider, M. (eds) In Silico Systems Biology. Methods in Molecular Biology, vol 1021. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-450-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-62703-450-0_7

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-449-4

  • Online ISBN: 978-1-62703-450-0

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics