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Cell Senescence as Both a Dynamic and a Static Phenotype

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Cell Senescence

Part of the book series: Methods in Molecular Biology ((MIMB,volume 965))

Abstract

It has been 50 years since cellular senescence was first described in human diploid fibroblasts (HDFs), yet its mechanism as well as its physiological and clinical implications are still not fully appreciated. Recent progress suggests that cellular senescence is a collective phenotype, composed of complex networks of effector programs. The balance and quality within the effector network varies depending on the cell type, the nature of the stress as well as the context. Therefore, understanding each of these effectors in the context of the whole network will be necessary in order to fully understand senescence as a whole. Furthermore, searching for new effector programs of senescence will help to define this heterogeneous and complex phenotype according to cellular contexts.

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Acknowledgments

Our work is supported by Cancer Research UK.

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Authors and Affiliations

  1. Cancer Research UK, Cambridge Research Institute, Cambridge, UK

    Andrew R. J. Young, Masako Narita & Masashi Narita

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  1. Andrew R. J. Young
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  2. Masako Narita
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  3. Masashi Narita
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Corresponding author

Correspondence to Masashi Narita .

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Editors and Affiliations

  1. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif, 94085, France

    Lorenzo Galluzzi

  2. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif CEDEX, 94085, France

    Ilio Vitale

  3. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif CEDEX, 94085, France

    Oliver Kepp

  4. Institut Gustave Roussy (IGR), Pavillon de Recherche 1, INSERM, U848, rue Camille-Desmoulins 39, Villejuif, 94805, France

    Guido Kroemer

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Young, A.R.J., Narita, M., Narita, M. (2013). Cell Senescence as Both a Dynamic and a Static Phenotype. In: Galluzzi, L., Vitale, I., Kepp, O., Kroemer, G. (eds) Cell Senescence. Methods in Molecular Biology, vol 965. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-239-1_1

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  • DOI: https://doi.org/10.1007/978-1-62703-239-1_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-238-4

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