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Dietary Mg Intake and Biomarkers of Inflammation and Endothelial Dysfunction

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Magnesium in Human Health and Disease

Part of the book series: Nutrition and Health ((NH))

Abstract

Magnesium (Mg) is an essential mineral found abundantly in whole grains, leafy green vegetables, legumes, and nuts that plays a central role in hundreds of physiological processes in the human body. According to national survey data from National Health and Nutrition Examination Survey (NHANES) 1999–2000, a large proportion of the US population consumes inadequate dietary Mg [1]. Given the fundamental role of Mg in diverse cellular reactions, this is not without consequence. Low dietary Mg intake has been linked to a range of adverse health outcomes including those related to metabolic and inflammatory processes such as hypertension [2, 3], type 2 diabetes (T2D) [4], and metabolic syndrome [2] in both experimental and observational settings. The pathophysiologic mechanisms underlying these relations are not well understood; however, a maturing body of evidence suggests that suboptimal dietary Mg intake status may affect metabolism and inflammation pathways ultimately leading to the clinical manifestation of T2D, metabolic syndrome, and CVD.

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Authors and Affiliations

  1. UCLA Departments of Epidemiology, Medicine, and Obstetrics & Gynecology, Center for Metabolic Disease Prevention, 650 Charles E. Young Drive South, Los Angeles, CA, 90095, USA

    Simin Liu M.D., Sc.D., M.P.H. (Professor of Epidemiology and Medicine)

  2. UCLA Department of Epidemiology, Center for Metabolic Disease Prevention, 650 Charles E. Young Drive South, Los Angeles, CA, 90095, USA

    Sara A. Chacko Ph.D., M.P.H. (Postdoctoral Fellow)

Authors
  1. Simin Liu M.D., Sc.D., M.P.H.
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  2. Sara A. Chacko Ph.D., M.P.H.
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Correspondence to Simin Liu M.D., Sc.D., M.P.H. .

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Editors and Affiliations

  1. Arizona Health Science Center, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

  3. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Liu, S., Chacko, S.A. (2013). Dietary Mg Intake and Biomarkers of Inflammation and Endothelial Dysfunction. In: Watson, R., Preedy, V., Zibadi, S. (eds) Magnesium in Human Health and Disease. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-044-1_2

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  • DOI: https://doi.org/10.1007/978-1-62703-044-1_2

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