Abstract
The endometrium plays a key role in successful implantation and pregnancy. A delicate balance exists between the antioxidant mechanisms and the reactive oxygen species in the endometrium. When pregnancy occurs, successful implantation results in the production of Human Chorionic Gonadotropin (HCG) which maintains progesterone levels. Progesterone increases the activity of superoxide dismutase in the endometrium which in turn suppresses the production of reactive oxygen species and prostaglandin F2α. (PGF2α). On the other hand, in the absence of pregnancy, progesterone levels drop and superoxide dismutase activity declines. As a result, cyclooxygenase enzyme 2 (COX2) and PGF2α increase, resulting in menstruation. HCG might improve the uterine environment prior to implantation by suppressing the apoptotic response to oxidative stress in the maternal decidua.
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References
DeCherney A, Hill MJ (2010) The future of imaging and assisted reproduction. In: Rizk B (ed) Ultrasonography in reproductive medicine and infertility. Cambridge University Press, Cambridge pp. 1–10 (Chapter 1)
Brown WW III (2010) Sonohysterography. In: Rizk B (ed) Ultrasonography in reproductive medicine and infertility. Cambridge University Press, Cambridge, pp 42–53 (Chapter 5)
Rizk B, Sallam HN (2012) The uterine factor in infertility. In: Rizk B, Sallam HN (eds) Clinical infertility and in vitro fertilization. Jaypee Brothers Medical Publishers, St. Louis, pp 84–96 (Chapter 7)
de Zeigler D, Fraisse T et al (2008) Endometrial receptivity. In: Rizk B, Garcia-Velasco J, Makrigiannakis A (eds) Infertility and assisted reproduction. Cambridge University Press, New York, pp 38–45 (Chapter 4)
Jauniaux E, Rizk B (eds) (2012) Pregnancy after reproductive technology. Cambridge University Press, Cambridge
Garcia-Velasco JA, Rizk B (eds) (2010) Endometriosis: current management and future trends. Jaypee Medical Publishers, St. Louis
Gardner DK, Rizk B, Falcone T (eds) (2011) Human assisted reproductive technology: future trends in laboratory and clinical practice (Cambridge Medicine). Cambridge University Press, Cambridge
Aboulghar M, Rizk B (eds) (2011) Ovarian stimulation. Cambridge University Press, Cambridge
Dickey RP (2010) The endometrium. In: Rizk B (ed) Ultrasonography in reproductive medicine and infertility. Cambridge University Press, Cambridge, pp 97–102 (Chapter 12)
Sugino N (2007) The role of oxygen radical-mediated signaling pathways in endometrial function. Placenta 28(Suppl A), Trophoblast Res 21:S133–S136
Sugino N, Shimamura K, Takiguchi S et al (1996) Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and in early pregnancy. Hum Reprod 11:1073–1078
Sugino N, Karube-Harada A, Kashida S et al (2001) Reactive oxygen species stimulate prostaglandin F2α production in human endometrial stromal cells in vitro. Hum Reprod 16:1797–1801
Sugino N, Nakata M, Kashida S et al (2000) Decreased superoxide dismutase expression and increased concentrations of lipid peroxide and prostaglandin F2-α in the decidua of failed pregnancy. Mol Hum Reprod 6:642–647
Sugino N, Karube-Harada A, Sakata A et al (2002) Different mechanisms for the induction of copper-zinc superoxide dismutase and manganese superoxide dismutase by progesterone human endometrial stromal cells. Hum Reprod 17:1709–1714
Rizk B (2006) Ovarian hyperstimulation syndrome: epidemiology, pathophysiology, prevention and management. Cambridge University Press, Cambridge
Rizk B (2009) Genetics of ovarian hyperstimulation syndrome. Reprod Biomed Online 19:14–27
Rizk B, Smitz J (1992) Ovarian hyperstimulation syndrome after superovulation using GnRH agonists for IVF and related procedures. Hum Reprod 7:320–327
Kajihara T, Uchino S, Itakura A (2011) Human chorionic gonadotropin confers resistance to oxidative stress-induced apoptosis in decidualizing human endometrial stromal cells. Fertil Steril 95(4):1302–1307 Mar 15
Leitao B, Jones MC, Fusi L et al (2010) Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals. FASEB J 24(5):1541–1551 May
Ax Liu, He WH, Yin LJ, Lv PP et al (2011) Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss. J Clin Endocrinol Metab 96(3):E493–E497
Brosens JJ, Wilson MS, Lam EW (2009) FOXO transcription factors: from cell fate decisions to regulation of human female reproduction. Adv Exp Med Biol 665:227–241
Cheong AW, Lee YL, Liu WM et al (2009) Oviductal microsomal epoxide hydrolase (EPHX1) reduce reactive oxygen species (ROS) level and enhances preimplantation mouse embryo development. Biol Reprod 81(1):126–132
Hirota Y, Acar N, Tranguch S et al (2010) Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin (PRDX6) signaling protects pregnancy from overt oxidative stress. Proc Natl Acad Sci USA 107(35):15577–15582
Burton GJ, Jauniaux E, Charnock-Jones DS (2010) The influence of the intrauterine environment on human placental development. Int J Dev Biol 54(2–3):303–312
Burton GJ, Woods AW, Jauniaux E et al (2009) Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 30(6):473–482
Burton GJ, Yung HW, Cindrova-Davies T, Charmock-Jones DS (2009) Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia. Placenta 30(Suppl A):S43–S48
Pejic S, Todorovic A, Stojiljokvic V (2009) Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma. Reprod Biol Endocrinol 23(7):149 Dec
Gupta S, Sekhon L, Aziz N, Agarwal A (2008) The impact of oxidative stress on female reproduction and ART: an evidence-based review. In: Rizk B, Garcia-Velasco J, Makrigiannakis A (eds) Infertility and assisted reproduction. Cambridge University Press, New York, pp 629–642 (Chapter 64)
Lee SR, Kim SH, Lee HW et al (2009) Increased expression of glutathione by estradiol, tumor necrosis factor-alpha, and interleukin 1-beta in endometrial stromal cells. Am J Reprod Immunol 62(6):352–356 Dec
Kobayashi H, Yamada Y, Kanayama S et al (2009) The role of iron in the pathogenesis of endometriosis. Gynecol Endocrinol 25(1):39–52 Jan
Gupta S (2012) Oxidative stress and and its role in endometriosis-mechanistic and therapeutic implications. In: Rizk B, Sallam H (eds) Clinical infertility and in vitro fertilization. Jaypee Brothers Medical Publishers, New Delhi, pp 316–325 (Chapter 37)
Park JK, Song M, Dominguez CE et al (2006) Glycodelin mediates the increase in vascular endothelial growth factor in response to oxidative stress in the endometrium. Am J Obstet Gynecol 195(6):1772–1777
Seo SK, Yang HI, Lee KE et al (2010) The roles of thioredoxin and thioredoxin-binding protein-2 in endometriosis. Hum Reprod 25(5):1251–1258
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Rizk, B., Badr, M., Talerico, C. (2013). Oxidative Stress and The Endometrium. In: Agarwal, A., Aziz, N., Rizk, B. (eds) Studies on Women's Health. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-041-0_3
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DOI: https://doi.org/10.1007/978-1-62703-041-0_3
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