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Simulations of Lipid Monolayers

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Biomolecular Simulations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 924))

Abstract

A lipid monolayer lining a boundary between two immiscible phases forms a complex interface with inhomogeneous distribution of forces. Unlike lipid bilayers, monolayers are formed in asymmetric environment and their properties depend strongly on lipid surface density. The monolayer properties are also affected significantly by the representation of the pure interface. Here we give a brief theoretical introduction and describe methods to simulate lipid monolayers starting from force-fields and system setup to reproducing state points on the surface tension (pressure)–area isotherms and transformations between them.

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Acknowledgments

SB is supported by postdoctoral fellowship from the Alberta Heritage Foundation for Medical Research (AHFMR). DPT is an Alberta Ingenuity Health Solutions Scientist and Alberta Ingenuity Technology Futures Strategic Chair in (Bio)Molecular Simulation. This work was supported by the Natural Sciences and Engineering Research Council (Canada).

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Authors and Affiliations

  1. Department of Biological Sciences, University of Calgary, Calgary, AB, Canada

    Svetlana Baoukina & D. Peter Tieleman

Authors
  1. Svetlana Baoukina
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  2. D. Peter Tieleman
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Correspondence to Svetlana Baoukina .

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Editors and Affiliations

  1. DSIMB, UMR-S 665, INSERM, rue Alexandre Cabanel 6, Paris, 75015, France

    Luca Monticelli

  2. , Department of Applied Physics, Aalto University, Otakaari, AALTO, FI-00076, Finland

    Emppu Salonen

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Baoukina, S., Tieleman, D.P. (2013). Simulations of Lipid Monolayers. In: Monticelli, L., Salonen, E. (eds) Biomolecular Simulations. Methods in Molecular Biology, vol 924. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-017-5_16

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  • DOI: https://doi.org/10.1007/978-1-62703-017-5_16

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-016-8

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