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Nonmammalian Parent-of-Origin Effects

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Genomic Imprinting

Part of the book series: Methods in Molecular Biology ((MIMB,volume 925))

Abstract

Chromosomes acquire different epigenetic marks during oogenesis and spermatogenesis. After fertilization, if retained and selected, these differences may result in imprinting effects. Rather than being an oddity, imprinting effects have been found in many sexually reproducing organisms. Interestingly, imprinting can result in disparate effects under different selective forces. At the same time, epigenetic mechanisms and selective pressures shared by sexually reproducing organisms could underlie common imprinting effects. Large-scale studies are revealing that parent-of-origin effects are more common than previously thought and supporting the important contribution of imprinting to many traits and diseases.

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Acknowledgments

I apologize to colleagues whose original research papers could not be cited due to space limitations. I would like to thank Elena Becker Barroso and Jose Javier García Ramírez for their helpful comments to this manuscript. I am also grateful to Francisco R. Jiménez Díaz for technical support and to the Consejería de Educación y Ciencia (ref. PPII10-0259-4347) for financial support.

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  1. Albacete Science and Technology Park, Regional Center for Biomedical Research (C.R.I.B.), University of Castilla-La Mancha, Albacete, Spain

    Elena de la Casa-Esperón

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  1. Elena de la Casa-Esperón
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Correspondence to Elena de la Casa-Esperón .

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  1. School of Medicine, Fels Institute, Temple University, N. Broad Street 3307, Philadelphia, 19140, Pennsylvania, USA

    Nora Engel

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de la Casa-Esperón, E. (2012). Nonmammalian Parent-of-Origin Effects. In: Engel, N. (eds) Genomic Imprinting. Methods in Molecular Biology, vol 925. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-011-3_19

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  • DOI: https://doi.org/10.1007/978-1-62703-011-3_19

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