Abstract
Today’s data-intensive, interdisciplinary research challenges scientists to keep up to date with key experimental techniques and tools reported in the literature. The International Union of Basic and Clinical Pharmacology Database (IUPHAR-DB) goes some way to addressing this need by providing expert-curated information sourced from primary literature and displayed in a user-friendly manner online. The database provides a channel for the IUPHAR Nomenclature Committee (NC-IUPHAR) to provide recommendations on the nomenclature of receptors and ion channels, to document their properties and the ligands that are useful for receptor characterization. Here we describe IUPHAR-DB’s main features and provide examples of techniques for navigating and exploring the information. The database is freely available online at http://www.iuphar-db.org/.
The authors wish it to be known that the first two authors should be regarded as joint First Authors. NC-IUPHAR denotes International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification. The members of NC-IUPHAR are provided in Acknowledgement.
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Acknowledgements
The authors thank all contributors and members of NC-IUPHAR and its subcommittees for their ongoing support. NC-IUPHAR members: S.P.H. Alexander, T.I. Bonner, W.A. Catterall, A. Christopoulos, A.P. Davenport, C.T. Dollery, S. Enna, A.J. Harmar, K. Kaibuchi, Y. Kanai, V. Laudet, R.R. Neubig, E.H. Ohlstein, J. Peters, J-P. Pin, U. Ruegg, P. du Souich, M. Spedding, and M.W. Wright. IUPHAR-DB has been developed with financial support from the British Pharmacological Society, ASPET, Servier, GlaxoSmithKline, Pfizer, Actelion, AstraZeneca, DiscoveRx, Lundbeck, Abbott, and Merck Millipore.
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Mpamhanga, C.P., Sharman, J.L., Harmar, A.J., NC-IUPHAR. (2012). How to Use the IUPHAR Receptor Database to Navigate Pharmacological Data. In: Davenport, A. (eds) Receptor Binding Techniques. Methods in Molecular Biology, vol 897. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-909-9_2
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DOI: https://doi.org/10.1007/978-1-61779-909-9_2
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