Abstract
The Taguchi method together with Minitab software was used to optimize the melt spun PLLA multifilament fiber finesse. The aim was to minimize the number of spinning experiments to find optimal processing conditions and to maximize the quality of the fibers (thickness, strength, and smoothness). The optimization was performed in two parts. At first, the melt spinning process was optimized considering the drawing that followed and at second step the drawing was optimized. Fine (15 μm) fibers with feasible strength properties (730 MPa) for further processing were produced with the aid of Minitab software.
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References
Chu CC (2001) Textile-based biomaterials for surgical applications. In: Severian D (ed) Polymeric biomaterials, 2nd edn. Marcel Dekker, New York, USA, pp 491–544
Patrick CW Jr, Mikos AG, McIntyre LV (eds) (1998) Frontiers in tissue engineering. Pergamon, Oxford, UK
Nerem RM, Sambanis A (1995) Tissue engineering: from biology to biological substitutes. Tissue Eng 1:3–13
Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R (1994) Preparation and characterization of poly (l-lactic acid) foams. Polymer 35(5):1068–1077
Thomson RC, Wake MC, Yaszemski M, Mikos AG (1995) Biodegradable polymer scaffolds to regenerate organs. Adv Polym Sci 122:247–274
Park A, Wu B, Griffith LG (1998) Integration of surface modification and 3D fabrication techniques to prepare patterned poly(l-lactide) substrates allowing regionally selective cell adhesion. J Biomater Sci Polym Edn 9(2):89–110
Landers R, Hübner U, Schmelzeisen R, Mülhaupt R (2002) Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering. Biomaterials 23(23):4437–4447
Hile DD, Amirpour ML, Akgerman A, Pishko MV (2000) Active growth factor delivery from poly(d, l-lactide-co-glycolide) foams prepared in supercritical CO2. J Control Release 66:177–185
Honkanen PB, Kellomäki M, Lehtimäki MY, Törmälä P, Mäkelä OT, Lehto MUK (2003) Bioreconstructive joint scaffold implant arthroplasty in metacarpophlangeal joints: short-term results of a new treatment in rheumatoid arthritis patients. Tissue Eng 9(5):957–965
Laukkarinen J, Sand J, Chow P, Juuti H, Kellomäki M, Kärkkäinen P, Isola J, Yu S, Somanesan S, Kee I, Song IC, Teck HN, Nordback I (2007) A novel biodegradable biliary stent in the normal duct hepaticojejunal anastomosis: an 18-month follow-up in a large animal model. J Gastrointest Surg 11:750–757
Gundy S, Manning G, O’Connel E, Ellä V, Sri Harwoko M, Rochev Y, Smith T, Barron V (2008) Human coronary artery smooth muscle cell response to a novel PLA textile/fibrin gel composite scaffold. Acta Biomater 4:1734–1744
Cao Y, Vacanti JP, Paige KT, Upton J, Vacanti CA (1997) Trasplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg 100:297–302
Fourné F (ed) (1999) Synthetic fibers. Hanser Publishers, Munich, Germany
Wake NC, Patrick CW, Mikos AG (1994) Pore morphology effects on the fibrovascular tissue growth in porous polymer substrates. Cell Transpl 3:339–343
Nehrer S, Breinan HA, Ramappa A, Young G, Shortkroff S, Louie LK, Sledge CB, Yannas IV, Spector M (1997) Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes. Biomaterials 18:769–776
Grande DA, Halberstad C, Naughton G, Schwartz R, Manji R (1997) Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts. J Biomed Mater Res 34:211–220
Pulliainen O, Vasara AI, Hyttinen MM, Tiitu V, Valonen P, Kellomäki M, Jurvelin JS, Peterson L, Lindahl A, Kiviranta I, Lammi MJ (2007) Poly-l-d-lactic acid scaffold in the repair of porcine knee cartilage lesions. Tissue Eng 13(6):1347–1355
Taguchi G, Chowdhury S, Wu Y (eds) (2004) Taguchi’s quality engineering handbook. JohnWiley and Sons, New Jersey, USA
Huang CC, Tang TT (2006) Parameter optimization in melt spinning by neural networks and genetic algorithms. Int J Adv Manuf Techol 27:1113–1118
Huang CC, Tang TT (2006) Optimizing multiple qualities in as-spun polypropylene yarn by neural networks and genetic algorithms. J Appl Polym Sci 100(3):2532–2541
Wang MW, Jeng JH (2009) Optimal molding parameter design of PLA micro lancet needles using the Taguchi method. Polym Plast Technol 48(7):730–735
Patra SN, Easteal AJ, Bhattacharyya D (2009) Parametric study of manufacturing poly(lactic) acid nanofibrous mat by electrospinning. J Mater Sci 44(2):647–654
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Ellä, V., Rajala, A., Tukiainen, M., Kellomäki, M. (2012). Using the Taguchi Method to Obtain More Finesse to the Biodegradable Fibers. In: Liebschner, M. (eds) Computer-Aided Tissue Engineering. Methods in Molecular Biology, vol 868. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-764-4_10
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DOI: https://doi.org/10.1007/978-1-61779-764-4_10
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