Abstract
Excessive risk taking is a hallmark of various psychopathological disorders. We have developed a task that models such risky decision making in rats. In this task, rats are given choices between small, safe rewards and large rewards accompanied by a risk of punishment (footshock). The risk of punishment increases throughout the test session, which allows the quantification of risky decision making at different degrees of risk for each subject. Importantly, this task yields a consistently wide degree of reliable individual variability, allowing the characterization of rats as “risk taking” or “risk averse.” This task has been demonstrated to be effective for testing the effects of pharmacological agents on risk taking, and the individual variability (which mimics the human population) allows assessment of neurobiological distinctions between subjects based on risk-taking profile.
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References
Bechara, A., Dolan, S., Denburg, N., Hindes, A., Anderson, S.W., and Nathan, P.E. (2001) Decision-making deficits, linked to dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia. 39, 376–389.
Drechsler, R., Rizzo, P., and Steinhausen, H.C. (2008) Decision-making on an explicit risk-taking task in preadolescents with attention-deficit/hyperactivity disorder. J Neural Transm. 115, 201–209.
Ernst, M., Kimes, A.S., London, E.D., Matochik, J.A., Eldreth, D., Tata, S., et al. (2003) Neural substrates of decision making in adults with attention deficit hyperactivity disorder. Am J Psychiatry. 160, 1061–1070.
Ludewig, K., Paulus, M.P., and Vollenweider, F.X. (2003) Behavioural dysregulation of decision-making in deficit but not nondeficit schizophrenia patients. Psychiatry Res. 119, 293–306.
Evenden, J.L. and Ryan, C.N. (1996) The pharmacology of impulsive behavior in rats: the effects of drugs on response choice with varying delays of reinforcement. Psychopharmacology (Berl). 128, 161–170.
Cardinal, R.N., Robbins, T.W., and Everitt, B.J. (2000) The effects of d-amphetamine, chlordiazepoxide, α-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats. Psychopharmacology (Berl). 152, 362–375.
Winstanley, C.A., Dalley, J.W., Theobald, D.E., and Robbins, M.J. (2003) Global 5-HT depletion attenuates the ability of amphetamine to decrease impulse choice on a delay-discounting task in rats. Psychopharmacology (Berl). 170, 320–31.
Simon, N.W., Mendez, I.A., and Setlow, B. (2007) Cocaine exposure causes long term increases in impulsive choice. Behav Neurosci. 121, 543–9.
Simon, N.W., Gilbert, R.J., Mayse, J.D., Bizon, J.L., and Setlow, B. (2009) Balancing risk and reward: a rat model of risky decision making. Neuropsychopharm. 34, 2208–17.
Van Den Bos, R., Lasthius, W., Den Heijer, E., Van Der Harst, J., and Spruijt, B. (2006) Toward a rodent model of the Iowa gambling task. Behav Res Methods. 38, 470–478.
Zeeb, F.D., Robbins, T.W., and Winstanley, C.A. (2009) Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task. Neuropsychopharm. 34, 2329–2343.
Jentsch, J.D., Woods, J.A., Groman, S.M., and Seu, E. (2010) Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the Balloon Analog Risk Task. Neuropsychopharm. 35, 1797–806.
Cardinal, R. and Howes, N. (2005) Effects of lesions of the nucleus accumbens core on choice between small certain rewards and large uncertain rewards in rats. BMC Neurosci. 6, 37.
Negus, S. (2005) Effects of punishment on choice between cocaine and food in rhesus monkeys. Psychopharmacology (Berl). 181, 244–252.
Talmi, D., Dayan, P., Kiebel, S.J., Frith, C.D., and Dolan, R.J. (2009) How humans integrate the prospects of pain and reward during choice. J. Neurosci. 29, 14617–14626.
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Simon, N.W., Setlow, B. (2012). Modeling Risky Decision Making in Rodents. In: Kobeissy, F. (eds) Psychiatric Disorders. Methods in Molecular Biology, vol 829. Humana Press. https://doi.org/10.1007/978-1-61779-458-2_10
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DOI: https://doi.org/10.1007/978-1-61779-458-2_10
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