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Practical Considerations of Genetic Rodent Models for Neurodegenerative Diseases

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Neurodegeneration

Part of the book series: Methods in Molecular Biology ((MIMB,volume 793))

Abstract

In recent years, the rapid advances in human genetics have identified many genes that are responsible for inherited diseases. In the effort to understand pathogenic pathways and develop therapeutics, researchers have developed genetic animal models as critical tools for the purpose of neurodegenerative disease study. In this overview chapter, we do not intend to cover all the transgenic models for particular diseases, their phenotypical analyses, and their specific usage in this research field. Instead, we outline methods of genetic manipulation and their usage in disease modeling, explain the underlying principles of these methods, and compare the advantages and pitfalls to these different transgenic methods.

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Author information

Authors and Affiliations

  1. Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA

    Kindiya Geghman

  2. Department of Neurology, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA

    Chenjian Li

Authors
  1. Kindiya Geghman
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  2. Chenjian Li
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Corresponding author

Correspondence to Chenjian Li .

Editor information

Editors and Affiliations

  1. Weill Medical College, Dept. Neurology & Neuroscience, Cornell University, East 68th St. 525, New York, 10065, New York, USA

    Giovanni Manfredi

  2. York Avenue 1300, New York, 10065, New York, USA

    Hibiki Kawamata

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© 2011 Springer Science+Business Media, LLC

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Geghman, K., Li, C. (2011). Practical Considerations of Genetic Rodent Models for Neurodegenerative Diseases. In: Manfredi, G., Kawamata, H. (eds) Neurodegeneration. Methods in Molecular Biology, vol 793. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-328-8_12

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  • DOI: https://doi.org/10.1007/978-1-61779-328-8_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-327-1

  • Online ISBN: 978-1-61779-328-8

  • eBook Packages: Springer Protocols

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