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HIV-1-Induced Alterations of Claudin-5 Expression at the Blood–Brain Barrier Level

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Claudins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 762))

Abstract

HIV-1 crosses the blood–brain barrier (BBB) early in the course of systemic infection and resides in brain macrophages and microglia. The integrity of the brain endothelium is regulated by intercellular tight junctions, which also play a critical role in HIV-1-entry into the brain. Disruption of tight junctions, including changes in claudin-5 expression, is common in HIV-1-infected patients. Recent evidence indicates that both exposure to HIV-1 and HIV-1 specific proteins, such as Tat protein, can contribute to alterations of expression and distribution of claudin-5 in brain endothelial cells and brain microvessels.

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Acknowledgments

This work was supported by MH63022, MH072567, and NS39254.

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Authors and Affiliations

  1. Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical School, Lexington, KY, USA

    Michal Toborek

Authors
  1. Ibolya E. András
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  2. Michal Toborek
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Corresponding author

Correspondence to Michal Toborek .

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Editors and Affiliations

  1. Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Smyth Road 501, Ottawa, K1Y 8L6, Canada

    Kursad Turksen

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András, I.E., Toborek, M. (2011). HIV-1-Induced Alterations of Claudin-5 Expression at the Blood–Brain Barrier Level. In: Turksen, K. (eds) Claudins. Methods in Molecular Biology, vol 762. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-185-7_26

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  • DOI: https://doi.org/10.1007/978-1-61779-185-7_26

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-184-0

  • Online ISBN: 978-1-61779-185-7

  • eBook Packages: Springer Protocols

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