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Nutritional Control of Cell Growth via TOR Signaling in Budding Yeast

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Yeast Systems Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 759))

Abstract

Cell growth is highly regulated and its deregulation is related to many human diseases such as cancer. Nutritional cues stimulate cell growth through modulation of TOR (target of rapamycin) signaling pathway. At the center of this pathway is a large serine/threonine protein kinase TOR, which forms two distinct functional complexes TORC1 and TORC2 in a cell. TORC1 senses the environmental nutrient quality/quantity and transmits the growth signals to multiple effectors to regulate a broad spectrum of biological processes including translation initiation, ribosome biogenesis, autophagy, nutrient uptake, and metabolism. By using budding yeast as a model, recent studies began to elucidate the complexity of the TOR signaling pathway.

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Author information

Authors and Affiliations

  1. Graduate Program in Cellular and Molecular Pharmacology, Department of Pharmacology, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA

    Yuehua Wei

  2. Department of Pharmacology, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA

    X.F. Steven Zheng

Authors
  1. Yuehua Wei
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  2. X.F. Steven Zheng
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Corresponding author

Correspondence to X.F. Steven Zheng .

Editor information

Editors and Affiliations

  1. , Department of Biochemistry, University of Cambridge, Tennis Court Road 80, Cambridge, CB2 1GA, United Kingdom

    Juan I. Castrillo

  2. , Department of Biochemistry, University of Cambridge, Tennis Court Road 80, Cambridge, CB2 1GA, United Kingdom

    Stephen G. Oliver

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© 2011 Humana Press

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Wei, Y., Zheng, X.S. (2011). Nutritional Control of Cell Growth via TOR Signaling in Budding Yeast. In: Castrillo, J., Oliver, S. (eds) Yeast Systems Biology. Methods in Molecular Biology, vol 759. Humana Press. https://doi.org/10.1007/978-1-61779-173-4_18

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  • DOI: https://doi.org/10.1007/978-1-61779-173-4_18

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-172-7

  • Online ISBN: 978-1-61779-173-4

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