Abstract
For a long time, adipose tissue was only considered for its crucial role in energy balance and associated diseases. The discovery of the presence of immature cells highlights a putative role for these tissues as reservoirs of therapeutic cells. Indeed, since fat pads can be sampled by liposuction under local anesthesia in adult patients, adipose tissue represents a promising source of regenerative cells, particularly in cardiovascular regeneration. Indeed among other potentials, we and others have demonstrated the great angiogenic properties of adipose-derived stromal cells (ASCs) and the existence of peculiar cells, at least in mice, that are able to spontaneously give rise to functional cardiomyocytes. This review deciphers the different steps necessary to isolate, characterize, and manipulate such striking cells.
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Acknowledgment
This work was supported by National Research Program on cardiovascular diseases (# PN PNC0 C0402), Cell and Genetic Therapy program from Région Midi-Pyrénées (# 03 03011 011999 999), Interreg 3 (# 13 13A- A-7-85-O) and Fondation pour la Recherche Médicale (DCV20070409252, programme Vieillissement Cardiovasculaire Normal et Pathologique). S. De Barros and S. Dehez are financially supported by FRM and Etablissement Français du Sang Pyrénées-Méditerrannée respectively.
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Casteilla, L., Planat-Bénard, V., Dehez, S., De Barros, S., Barreau, C., André, M. (2011). Endothelial and Cardiac Regeneration from Adipose Tissues. In: Gimble, J., Bunnell, B. (eds) Adipose-Derived Stem Cells. Methods in Molecular Biology, vol 702. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61737-960-4_20
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DOI: https://doi.org/10.1007/978-1-61737-960-4_20
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