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Integrative Systems Biology Approaches to Identify and Prioritize Disease and Drug Candidate Genes

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Disease Gene Identification

Part of the book series: Methods in Molecular Biology ((MIMB,volume 700))

Abstract

Although a number of computational approaches have been developed to integrate data from multiple sources for the purpose of predicting or prioritizing candidate disease genes, relatively few of them focus on identifying or ranking drug targets. To address this deficit, we have developed an approach to specifically identify and prioritize disease and drug candidate genes. In this chapter, we demonstrate the applicability of integrative systems-biology-based approaches to identify potential drug targets and candidate genes by employing information extracted from public databases. We illustrate the method in detail using examples of two neurodegenerative diseases (Alzheimer’s and Parkinson’s) and one neuropsychiatric disease (Schizophrenia).

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Author information

Authors and Affiliations

  1. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Vivek Kaimal, Eric E. Bardes, Ranga Chandra Gudivada & Anil G. Jegga

  2. Department of Computer Science, College of Engineering, University of Cincinnati, Cincinnati, OH, USA

    Divya Sardana

  3. Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA

    Jing Chen

  4. Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA

    Vivek Kaimal & Anil G. Jegga

  5. Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA

    Anil G. Jegga

Authors
  1. Vivek Kaimal
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  2. Divya Sardana
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  3. Eric E. Bardes
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  4. Ranga Chandra Gudivada
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  5. Jing Chen
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  6. Anil G. Jegga
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Corresponding author

Correspondence to Anil G. Jegga .

Editor information

Editors and Affiliations

  1. Research Institute, Diabetes, Cardiovascular, &, Translational Genomics, North 5th St. 445, Phoenix, 85004, Arizona, USA

    Johanna K. DiStefano

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Kaimal, V., Sardana, D., Bardes, E.E., Gudivada, R.C., Chen, J., Jegga, A.G. (2011). Integrative Systems Biology Approaches to Identify and Prioritize Disease and Drug Candidate Genes. In: DiStefano, J. (eds) Disease Gene Identification. Methods in Molecular Biology, vol 700. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61737-954-3_16

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  • DOI: https://doi.org/10.1007/978-1-61737-954-3_16

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-953-6

  • Online ISBN: 978-1-61737-954-3

  • eBook Packages: Springer Protocols

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