Abstract
Mass spectrometry is a method of choice for quantifying low-abundance proteins and peptides in many biological studies. Here, we describe a range of computational aspects of protein and peptide quantitation, including methods for finding and integrating mass spectrometric peptide peaks, and detecting interference to obtain a robust measure of the amount of proteins present in samples.
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Acknowledgments
This work was supported by funding provided by the National Institutes of Health Grants RR00862, RR022220, NS050276, and CA126485, the Carl Trygger foundation, and the Swedish research council.
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Zhang, G. et al. (2010). Protein Quantitation Using Mass Spectrometry. In: Fenyö, D. (eds) Computational Biology. Methods in Molecular Biology, vol 673. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-842-3_13
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DOI: https://doi.org/10.1007/978-1-60761-842-3_13
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