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Systems Biology of Cell Behavior

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Systems Biology in Drug Discovery and Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 662))

Abstract

Systems Biology approaches to drug discovery largely focus on the increasing understanding of intracellular and cellular circuits, by computational representation of a molecular system followed by parameter validation against experimental data. This chapter outlines a universal approach to systems biology that allows the linking of intracellular molecular machinery and cellular activity. This procedure is achieved by applying mathematical modeling to molecular modules of a cell in the light of systems biology techniques.

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Author information

Authors and Affiliations

  1. Systems Biology Lab, Department of Engineering, University of Leicester, Leicester, UK

    Najl V. Valeyev & Declan G. Bates

  2. St John’s Institute of Dermatology, Kings College London, London, UK

    Najl V. Valeyev & Yoshinori Umezawa

  3. Biophysics & Bionics Lab, Department of Physics, Kazan State University, Kazan, Russia

    Antonina N. Gizatullina & Nikolay V. Kotov

Authors
  1. Najl V. Valeyev
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  2. Declan G. Bates
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  3. Yoshinori Umezawa
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  4. Antonina N. Gizatullina
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  5. Nikolay V. Kotov
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Editor information

Editors and Affiliations

  1. PharmTao, Santa Clara, California, USA

    Qing Yan

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© 2010 Springer Science+Business Media, LLC

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Valeyev, N.V., Bates, D.G., Umezawa, Y., Gizatullina, A.N., Kotov, N.V. (2010). Systems Biology of Cell Behavior. In: Yan, Q. (eds) Systems Biology in Drug Discovery and Development. Methods in Molecular Biology, vol 662. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-800-3_4

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  • DOI: https://doi.org/10.1007/978-1-60761-800-3_4

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-799-0

  • Online ISBN: 978-1-60761-800-3

  • eBook Packages: Springer Protocols

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