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Rodent Models of Experimental Autoimmune Uveitis

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Autoimmunity

Part of the book series: Methods in Molecular Biology ((MIMB,volume 900))

Abstract

The model of experimental autoimmune uveitis (EAU) in mice and in rats is described. EAU targets immunologically privileged retinal antigens and serves as a model of autoimmune uveitis in humans as well as a model for autoimmunity in a more general sense. EAU is a well-characterized, robust, and reproducible model that is easily followed and quantitated. It is inducible with synthetic peptides derived from retinal autoantigens in commonly available strains of rats and mice. The ability to induce EAU in various gene-manipulated, including HLA-transgenic, mouse strains makes the EAU model suitable for the study of basic mechanisms as well as in clinically relevant interventions.

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Authors and Affiliations

  1. Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD, USA

    Rajeev K. Agarwal & Phyllis B. Silver

  2. Section on Immunoregulation, Laboratory of Immunology, National Eye Institute, Bethesda, MD, USA

    Rachel R. Caspi

Authors
  1. Rajeev K. Agarwal
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  2. Phyllis B. Silver
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  3. Rachel R. Caspi
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Correspondence to Rachel R. Caspi .

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Editors and Affiliations

  1. College of Medicine, Division of Rheumatology, State University of New York, UMU, East Adams St. 750, Syracuse, 13210, New York, USA

    Andras Perl

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Agarwal, R.K., Silver, P.B., Caspi, R.R. (2012). Rodent Models of Experimental Autoimmune Uveitis. In: Perl, A. (eds) Autoimmunity. Methods in Molecular Biology, vol 900. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-720-4_22

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  • DOI: https://doi.org/10.1007/978-1-60761-720-4_22

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