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Animal Models of Neurodegenerative Diseases

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Neural Cell Transplantation

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 549))

Summary

Animal models of neurodegenerative disease are excellent tools for studying pathogenesis and therapies including cellular transplantation. In this chapter, we describe different models of Huntington’s disease and Parkinson’s disease, stereotactic surgery (used in creation of lesion models and transplantation) and finally transplantation studies in these models.

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Acknowledgments

The authors would like to thank Mrs. Pam Tyers for excellent technical advice and assistance and Dr. Jenny Morton for provision of transgenic HD mice. The corresponding author’s work was supported by the Medical Research Council.

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Authors and Affiliations

  1. Cambridge Centre for Brain Repair, University of Cambridge, E.D. Adrian Building, Forvie Site, 5b Bateman Street, CB2 2PY, Cambridge, UK

    Wendy Phillips, Andrew Michell, Harald Pruess & Roger A. Barker

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  1. Wendy Phillips
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  2. Andrew Michell
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  3. Harald Pruess
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  4. Roger A. Barker
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Correspondence to Roger A. Barker .

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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Phillips, W., Michell, A., Pruess, H., Barker, R.A. (2009). Animal Models of Neurodegenerative Diseases. In: Gordon, D., Scolding, N. (eds) Neural Cell Transplantation. Methods in Molecular Biology™, vol 549. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-931-4_10

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    • DOI: https://doi.org/10.1007/978-1-60327-931-4_10

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