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The Changing Epidemiology of Lung Cancer

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Cancer Epidemiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 472))

Abstract

The 20th century witnessed the scourge of lung cancer as the disease rapidly rose the ranks to become the commonest cause of cancer mortality in the world. Epidemiological evidence conclusively associated cigarette smoking with the causation of lung cancer in the 1950s. Since then and the few decades after, lung cancer of the squamous cell or small cell histological subtypes was mainly diagnosed among male smokers in developed countries. As we move into the 21st century, the incidence of lung cancer is unlikely to abate but the burden will shift from the developed to the less-developed countries. Other epi-demiological changes of lung cancer include the narrowing of the gap between men and women affected by the disease, predominance of the adenocarcinoma histological subtypes as well as more never-smokers afflicted with the disease. Unless we eliminate tobacco smoking completely, lung cancer will continue its wrath into the 21st century.

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References

  1. Parkin DM, Bray F, Ferlay J, Pisanin P. (2005) Global cancer statistics, 2002. CA Cancer J Clin. 55, 74–108.

    Article  PubMed  Google Scholar 

  2. Doll R, Hill AB. (1950) Smoking and carcinoma of the lung; preliminary report. Br Med J. 2, 739–748.

    Article  CAS  PubMed  Google Scholar 

  3. Wynder EL, Graham EA. (1950) Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases. JAMA. 143, 329–336.

    CAS  Google Scholar 

  4. US Department of Health Education, and Welfare (DHEW). (1964) Smoking and health: a report of the Advisory Committee to the Surgeon General of the Public Health Service. DHEW-Public Health Service Publication No. 1103. Washington, DC: US Government Printing Office.

    Google Scholar 

  5. Royal College of Physicians of London. (1962) Smoking and health: summary of a report of the Royal College of Physicians of London on smoking in relation to cancer of the lung and other disease. Publication No. S2–70. Pitman Medical Publishing, LTD, London, UK.

    Google Scholar 

  6. US Department of Health and Human Services (US-DHHS). (1980) The health consequences of smoking for women: a report of the Surgeon General. US-DHHS, Public Health Service, Office of the Assistant Secretary for Health, Office of Smoking and Health.

    Google Scholar 

  7. Devasa SS, Shaw GL, Blot WJ. (1991) Changing patterns of lung cancer incidence by histological type. Cancer Epidemiol Biomarkers Prev 1, 29–34.

    Google Scholar 

  8. Toh CK, Gao F, Lim WT, Leong SS, Fong KW, Yap SP, Hsu AA, Eng P, Koong HN, Thiruganam A, Tan EH. (2006) Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. J Clin Oncol. 24, 2245–2251.

    Article  PubMed  Google Scholar 

  9. US Department of Health and Human Services (US-DHHS). (2001) Women and smoking: a report of the Surgeon General. US-DHHS, Public Health Service, Office of the Surgeon General.

    Google Scholar 

  10. Center for Disease Control and Prevention. (2002) Trends in cigarette smoking among high school students—United States, 1991–2001. Morb Mortal Wkly Rep. 51, 409–412.

    Google Scholar 

  11. Center for Disease Control and Prevention. (2003) Tobacco use among middle and high school students–United States, 2002. Morb Mortal Wkly Rep. 52, 1096–1098.

    Google Scholar 

  12. Warren CW, Jones NR, Eriksen MP, Asma S, for the Global Tobacco Surveillance System (GTSS) Collaborative Group. (2006) Patterns of global tobacco use in young people and implications for future chronic disease burden in adults. Lancet. 367, 749–753.

    Article  CAS  PubMed  Google Scholar 

  13. Husten CG, Shelton DM, Chrismon JH, Lin YC, Mower P, Powell FA. (1997) Cigarette smoking and smoking cessation among older adults: United States, 1965–94. Tob Control. 6, 175–180.

    Article  CAS  PubMed  Google Scholar 

  14. Sorensen G, Pechacek TF. (1987) Attitudes toward smoking cessation among men and women. J Behav Med. 10, 129–137.

    Article  CAS  PubMed  Google Scholar 

  15. McDuffie HH, Klaassen DJ, Dosman JA. (1987) Female-male differences in patients with primary lung cancer. Cancer. 59, 1825–1830.

    Article  CAS  PubMed  Google Scholar 

  16. Brownson RC, Chang JC, Davis JR. (1992) Gender and histologic type variations in smoking-related risk of lung cancer. Epidemiology. 3, 61–64.

    Article  CAS  PubMed  Google Scholar 

  17. Risch HA, Howe GR, Jain M, Burch JD, Holowaty EJ, Miller AB. (1993) Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by his-tologic type. Am J Epidemiol. 138, 281–293.

    CAS  PubMed  Google Scholar 

  18. Harris RE, Zang EA, Anderson JI, Wynder EL. (1993) Race and sex differences in lung cancer risk associated with cigarette smoking. Int J Epidemiol. 22, 592–599.

    Article  CAS  PubMed  Google Scholar 

  19. Zang EA, Wynder EL. (1996) Differences in lung cancer risk between men and women: examination of the evidence. J Natl Cancer Inst. 88, 183–192.

    Article  CAS  PubMed  Google Scholar 

  20. International Early Lung Cancer Action Program Investigators. (2006) Women's susceptibility to tobacco carcinogens and survival after diagnosis of lung cancer. JAMA. 296, 180–184.

    Article  Google Scholar 

  21. Prescott E, Osler M, Hein HO, Borch-Johnsen K, Lange P, Schnohr P, Vestbo J. (1998) Gender and smoking-related risk of lung cancer. The Copenhagen Center for Prospective Population Studies. Epidemiology. 9, 79–83.

    Article  CAS  PubMed  Google Scholar 

  22. Bain C, Feskanich D, Speizer FE, Thun M, Hertzmark E, Rosner BA, Colditz GA. (2004) Lung cancer rates in men and women with comparable histories of smoking. J Natl Cancer Inst. 96, 826–834.

    Article  PubMed  Google Scholar 

  23. Taioli E, Wynder EL. (1994) Re: Endocrine factors and adenocarcinoma of the lung in women. J Natl Cancer Inst. 86, 869–870.

    Article  CAS  PubMed  Google Scholar 

  24. Gao YT, Blot WJ, Zheng W, Ershow AG, Hsu CW, Levin LI, Zhang R, Fraumeni JF Jr. (1987) Lung cancer among Chinese women. Int J Cancer. 40, 604–609.

    Article  CAS  PubMed  Google Scholar 

  25. Seow A, Poh WT, Teh M, Eng P, Wang YT, Tan WC, Chia KS, Yu MC, Lee HP. (2002) Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: evidence for a protective effect of soy in nonsmokers. Int J Cancer. 97, 365–371.

    Article  CAS  PubMed  Google Scholar 

  26. Mollerup S, Berge G, Baera R, Skaug V, Hewer A, Phillips DH, Stangeland L, Hau-gen A. (2004) Sex differences in risk of lung cancer: expression of genes in the PAH bio-activation pathway in relation to smoking and bulky DNA adducts. Int J Cancer. 119, 741–744.

    Article  Google Scholar 

  27. Dresler CM, Fratelli C, Babb J, Everley L, Evans AA, Clapper ML. (2000) Gender differences in genetic susceptibility for lung cancer. Lung Cancer. 30, 153–160.

    Article  CAS  PubMed  Google Scholar 

  28. Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, Fujisawa T, Feng Z, Roth JA, Herz J, Minna JD, Gazdar AF. (2005) Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 97, 339–346.

    Article  CAS  PubMed  Google Scholar 

  29. Tokumo M, Toyooka S, Kiura K, Shige-matsu H, Tomii K, Aoe M, Ichimura K, Tsuda T, Yano M, Tsukuda K, Tabata M, Ueoka H, Tanimoto M, Date H, Gazdar AF, Shimizu N. (2005) The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small-cell lung cancers. Clin Cancer Res. 11, 1167–1173.

    CAS  PubMed  Google Scholar 

  30. Enstrom JE. (1979) Rising lung cancer mortality among nonsmokers. J Natl Cancer Inst. 62, 755–760.

    CAS  PubMed  Google Scholar 

  31. Boffetta P, Jarvholm B, Brennan P, Nyren O. (2001) Incidence of lung cancer in a large cohort of non-smoking men from Sweden. Int J Cancer. 94, 591–593.

    Article  CAS  PubMed  Google Scholar 

  32. Thun MJ, Henly SJ, Burns D, Jemal A, Shanks TG, Calle EE. (2006) Lung cancer death rates in lifelong nonsmokers. J Natl Cancer Inst. 98:691–699.

    Article  PubMed  Google Scholar 

  33. Forastiere F, Perucci CA, Arca M, Axelson O. (1993) Indirect estimates of lung cancer death rates in Italy not attributable to active smoking. Epidemiology. 4, 502–510.

    Article  CAS  PubMed  Google Scholar 

  34. Sridhar KS, Raub WA Jr. (1992) Present and past smoking history and other predisposing factors in 100 lung cancer patients. Chest. 101, 19–25.

    Article  CAS  PubMed  Google Scholar 

  35. Zell JA, Ou SH, Ziogas A, Anton-Culver H. (2005) Epidemiology of bronchioloalveolar carcinoma: improvement in survival after release of the 1999 WHO classification of lung tumors. J Clin Oncol. 23, 8396–8405.

    Article  PubMed  Google Scholar 

  36. Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R. (2000) Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ. 321, 323–329.

    Article  CAS  PubMed  Google Scholar 

  37. Wakelee HA, Chang ET, Gomez SL, Keegan TH, Feskanich D, Clarke CA, Holmberg L, Yong LC, Kolonel LN, Gould MK, West DW. (2007) Lung cancer incidence in never smokers. J Clin Oncol. 25, 472–478.

    Article  PubMed  Google Scholar 

  38. Toh CK, Lim WT. (2007) Lung cancer in never smokers. J Clin Path. 60, 337–340.

    Article  PubMed  Google Scholar 

  39. Koo LC, Ho JH. (1990) Worldwide epide-miological patterns of lung cancer in non-smokers. Int J Epidemiol. 19 (Suppl 1), S14–23.

    PubMed  Google Scholar 

  40. Chen CJ, Wu HY, Chuang YC, Chang AS, Luh KT, Chao HH, Chen KY, Chen SG, Lai GM, Huang HH. (1990) Epidemiologic characteristics and multiple risk factors of lung cancer in Taiwan. Anticancer Res. 10, 971–976.

    CAS  PubMed  Google Scholar 

  41. Nordquist LT, Simon GR, Cantor A, Alberts WM, Bepler G. (2004) Improved survival in never-smokers vs current smokers with primary adenocarcinoma of the lung. Chest. 126, 347–351.

    Article  PubMed  Google Scholar 

  42. Tsao AS, Liu D, Lee JJ, Spitz M, Hong WK. (2006) Smoking affects treatment outcome in patient with advanced nonsmall cell lung cancer. Cancer. 106, 2428–2436.

    Article  PubMed  Google Scholar 

  43. Suzuki H, Takahashi T, Kuroishi T, Suyama M, Ariyoshi Y, Takahashi T, Ueda R. (1992) p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking. Cancer Res. 52, 734–736.

    CAS  PubMed  Google Scholar 

  44. Powell CA, Spira A, Derti A, DeLisi C, Liu G, Borczuk A, Busch S, Sahasrabudhe S, Chen Y, Sugarbaker D, Bueno R, Richards WG, Brody JS. (2003) Gene expression in lung adenocarcinomas of smokers and non-smokers. Am J Respir Cell Mol Biol. 29, 157–162.

    Article  CAS  PubMed  Google Scholar 

  45. Toyooka S, Tokumo M, Shigematsu H, Matsuo K, Asano H, Tomii K, Ichihara S, Suzuki M, Aoe M, Date H, Gazdar AF, Shimizu N. (2006) Mutational and epige-netic evidence for independent pathways for lung adenocarcinoma arising in smokers and never smokers. Cancer Res. 66, 1371–1375.

    Article  CAS  PubMed  Google Scholar 

  46. Bromen K, Pohlabeln H, Jahn I, Ahrens W, Jockel KH. (2000) Aggregation of lung cancer in families: results from a population-based case-control study in Germany. Am J Epidemiol. 152, 497–505.

    Article  CAS  PubMed  Google Scholar 

  47. Schwartz AG, Rothrock M, Yang P. (1999) Increased cancer risk among relatives of nonsmoking lung cancer cases. Genet Epidemiol. 17, 1–15.

    Article  CAS  PubMed  Google Scholar 

  48. Gorlova OY, Zhang Y, Schabath MB, Lei L, Zhang Q, Amos CI, Spitz MR. (2006) Never smoker and lung cancer risk: a case-control study of epidemiological factors. Int J Cancer. 118, 1798–1804.

    Article  CAS  PubMed  Google Scholar 

  49. Cheng YW, Chiou HL, Sheu GT, Hsieh LL, Chen JT, Chen CY, Su JM, Lee H. (2001) The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women. Cancer Res. 61, 2799–2803.

    CAS  PubMed  Google Scholar 

  50. Ko YC, Cheng LS, Lee CH, Huang JJ, Huang MS, Kao EL, Wang HZ, Lin HJ. (2000) Chinese food cooking and lung cancer in women nonsmokers. Am J Epidemiol. 151, 140–147.

    CAS  PubMed  Google Scholar 

  51. Brennan P, Butler J, Agudo A, Benhamou S, Darby S, Fortes C, Jockel KH, Kreuzer M, Nyberg F, Pohlabeln H, Saracci R, Wich-man HE, Boffetta P. (2000) Joint effect of diet and environmental tobacco smoke on risk of lung cancer among nonsmokers. J Natl Cancer Inst. 92, 426–427.

    Article  CAS  PubMed  Google Scholar 

  52. Vincent RG, Pickren JW, Lane WW, Bross I, Takita H, Houten L, Gutierrez AC, Rzepka T. (1977) The changing histopathology of lung cancer: a review of 1682 cases. Cancer. 39, 1647–1655.

    Article  CAS  PubMed  Google Scholar 

  53. Valaitis J, Warren S, Gamble D. (1981) Increasing incidence of adenocarcinoma of the lung. Cancer. 47, 1042–1046.

    Article  CAS  PubMed  Google Scholar 

  54. Dodds L, Davis S, Polissar L. (1986) A population-based study of lung cancer incidence trends by histologic type, 1974–81. J Natl Cancer Inst. 76, 21–29.

    CAS  PubMed  Google Scholar 

  55. Travis WD, Travis LB, Devesa SS. (1995). Lung Cancer. Cancer. 75 (1 Supp), 191–202.

    Article  CAS  PubMed  Google Scholar 

  56. Ikeda T, Kurita Y, Inutsuka S, Tanaka K, Nakanishi Y, Shigematsu N, Nobutomo K. (1991) The changing pattern of lung cancer by histological type–a review of 1151 cases from a university hospital in Japan, 1970–1989. Lung Cancer. 7, 157–164.

    Article  Google Scholar 

  57. Janssen-Heijnen ML, Nab HW, van Reek J, van der Heijden LH, Schipper R, Coebergh JW. (1995) Striking changes in smoking behaviour and lung cancer incidence by histological type in south-east Netherlands, 1960–1991. Eur J Cancer. 31A, 949–952.

    Article  Google Scholar 

  58. McFarlane MJ, Feinstein AR, Wells CK. (1986) Clinical features of lung cancer discovered as a postmortem “ surprise. ” Chest. 90, 520–523.

    Article  CAS  PubMed  Google Scholar 

  59. Wells CK, Feinstein AR. (1988) Detection bias in the diagnostic pursuit of lung cancer. Am J Epidemiol. 128, 1016–1026.

    CAS  PubMed  Google Scholar 

  60. Kung IT, So KF, Lam TH. (1984) Lung cancer in Hong Kong Chinese: mortality and histological types, 1973–1982. Br J Cancer. 50, 381–388.

    CAS  PubMed  Google Scholar 

  61. Thun MJ, Lally CA, Flannery JT, Calle EE, Dana Flanders W, Health CW Jr. (1997) Cigarette smoking and changes in the his-topathology of lung cancer. J Natl Cancer Inst. 89, 1580–1586.

    Article  CAS  PubMed  Google Scholar 

  62. Wynder El, Graham EA, Croninger AB. (1953) Experimental production of carcinoma with cigarette tar. Cancer Res. 13, 855–864.

    CAS  PubMed  Google Scholar 

  63. Fischer S, Spiegelhalder B, Preussmann R. (1989) Influence of smoking parameters on the delivery of tobacco-specific nitrosamines in cigarette smoke—a contribution to relative risk evaluation. Carcinogenesis. 10, 1059–1066.

    Article  CAS  PubMed  Google Scholar 

  64. Hecht SS. (1997) Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst. 89, 1580–1586.

    Article  Google Scholar 

  65. Djordjevic MV, Hoffmann D, Hoffmann I. (1997) Nicotine regulates smoking patterns. Prev Med. 26, 435–440.

    Article  CAS  PubMed  Google Scholar 

  66. Kabat KC. (2003) Fifty years' experience of reduced-tar cigarettes: what do we know about their health effects? Inhal Toxicol. 15, 1059–1102.

    CAS  PubMed  Google Scholar 

  67. Harris JE, Thun MJ, Mondul AM, Calle EE. (2004) Cigarette tar yields in relation to mortality from lung cancer in the cancer prevention study II prospective cohort, 1982–8. BMJ. 328, 72.

    Article  PubMed  Google Scholar 

  68. Parkin DM, Pisani P, Ferlay J. (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer. 80, 827–841.

    Article  CAS  PubMed  Google Scholar 

  69. Pisani P, Parkin DM, Bray F, Ferlay J. (1999) Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer. 83, 18–29.

    Article  CAS  PubMed  Google Scholar 

  70. Yang G, Fan L, Tan J, Qi G, Zhang Y, Samet JM, Taylor CE, Becker K, Xu J. (1999) Smoking in China: findings of the 1996 National Prevalence Survey. JAMA. 282, 1247–1253.

    Article  CAS  PubMed  Google Scholar 

  71. Wright AA, Katz IT. (2007) Tobacco tightrope–balancing disease prevention and economic development in China. N Engl J Med. 356, 1493–1496.

    Article  CAS  PubMed  Google Scholar 

  72. Liu BQ, Peto R, Chen ZM, Boreham J, Wu YP, Li JY, Colin Campbell T, Chen JS. (1998) Emerging tobacco hazards in China: 1. Retrospective proportional mortality study of one million deaths. BMJ. 317, 1411–1422.

    CAS  PubMed  Google Scholar 

  73. Wingo PA, Ries LAG, Giovino GA, Miller DS, Rosenberg HM, Shopland DR, Thun MJ, Edwards BK. (1999) Annual report to the nation on the status of cancer, 1973–1996, with a special section on lung cancer and tobacco smoking. J Natl Cancer Inst. 91, 675–690.

    Article  CAS  PubMed  Google Scholar 

  74. Hoffmann D, Hoffmann I, El-Bayoumy K. The less harmful cigarette: a controversial issue. A tribute to Ernst L. Wynder. (2001) Chem Res Toxicol. 14, 767–790.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Oncology, National Cancer Centre, Singapore

    Chee-Keong Toh

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  1. Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Mukesh Verma PhD

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Toh, CK. (2009). The Changing Epidemiology of Lung Cancer. In: Verma, M. (eds) Cancer Epidemiology. Methods in Molecular Biology, vol 472. Humana Press. https://doi.org/10.1007/978-1-60327-492-0_19

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  • DOI: https://doi.org/10.1007/978-1-60327-492-0_19

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-491-3

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