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Choroid Plexus–Cerebrospinal Fluid Circulatory Dynamics: Impact on Brain Growth, Metabolism, and Repair

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Neuroscience in Medicine

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References

  1. Johanson C. The choroid plexus and volume transmission. In: Adelman G, ed. Encyclopedia for Neuroscience, Volume I. 3rd electronic edition. Boston: Birkhauser; 2004.

    Google Scholar 

  2. Davson H, Welch K, Segal MB, eds. The Physiology and Pathophysiology of the Cerebrospinal Fluid. London: Churchill Livingstone, 1987.

    Google Scholar 

  3. Johanson CE, Duncan JA, Klinge PM, Brinker T, Stopa EG, Silverberg GD. Multiplicity of cerebrospinal fluid functions: New challenges in health and disease. Cerebrospinal Fluid Res 2008; 5: 10.

    Google Scholar 

  4. Spector R, Johanson CE. Micronutrient and urate transport in choroid plexus and kidney: Implications for drug therapy. Pharm Res 2006; 23: 2515–24.

    Article  CAS  Google Scholar 

  5. Redzic ZB, Preston JE, Duncan JA, Chodobski A, Szmydynger-Chodobska J. The choroid plexus-cerebrospinal fluid system: from development to aging. Curr Top Dev Biol 2005; 71: 1–52.

    Article  PubMed  CAS  Google Scholar 

  6. Johanson CE, Duncan JA, Stopa EG, Baird A: Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. Pharm Res 2005; 22: 1011–37.

    Article  PubMed  CAS  Google Scholar 

  7. Chodobski A, Szmydynger-Chodobska J. Choroid plexus: target for polypeptides and site of their synthesis. Microsc Res Tech 2001; 52: 65–82.

    Article  PubMed  CAS  Google Scholar 

  8. Spector R, Johanson CE. The origin of deoxynucleosides in brain: Implications for the study of neurogenesis and stem cell therapy. Pharm Res 2007; 24: 859–67.

    Article  PubMed  CAS  Google Scholar 

  9. Spector R, Johanson CE. Vitamin transport and homeostasis in mammalian brain: focus on vitamins B and E. J Neurochem 2007; 103: 425–38.

    Google Scholar 

  10. Chodobski A, Szmydynger-Chodobska J, Epstein MH, Johanson CE. The role of angiotensin II in the regulation of blood flow to choroid plexuses and cerebrospinal fluid formation in the rat. J Cereb Blood Flow Metabol 1995; 15: 143–51.

    Article  CAS  Google Scholar 

  11. Johanson CE, Preston JE, Chodobski A, Stopa EG, Szmydynger-Chodobska J, McMillan PN. Arginine vasopressin V1-receptor-induced decrease in Cl transport and increase in dark cell frequency in choroid plexus. Am J Physiol (Cell) 1999; 276: C82–C90.

    CAS  Google Scholar 

  12. Johanson CE, Donahue JE, Spangenberger A, Stopa EG, Duncan JA, Sharma HS. Atrial natriuretic peptide: Its putative role in modulating the choroid plexus-CSF system for intracranial pressure regulation. Acta Neurochir 2006; 96: 481–6.

    Google Scholar 

  13. Johanson CE, Palm DE, Primiano MJ, McMillan PN, Chan P, Knuckey NW, Stopa EG. Choroid plexus recovery after transient forebrain ischemia: Role of growth factors and other repair mechanisms. Cell Mol Neurobiol 2000; 20: 197–216.

    Article  PubMed  CAS  Google Scholar 

  14. Schreiber G, Aldred AR, Jaworowski A, Nilsson C, Achen MG, Segal MB. Thyroxine transport from blood to brain via transthyretin synthesis in choroid plexus. Am J Physiol 1990; 258: R338–R345.

    PubMed  CAS  Google Scholar 

  15. Chen RL, Athauda SB, Kassem NA, Zhang Y, Segal MB, Preston JE. Decrease of transthyretin synthesis at the blood-cerebrospinal fluid barrier of old sheep. J Gerontol A Biol Sci Med Sci 2005; 60: 852–8.

    Article  PubMed  Google Scholar 

  16. Johanson CE, Silverberg GD, Donahue JE, Duncan JA, Stopa EG. Choroid plexus and CSF in Alzheimer’s disease: Altered expression and transport of proteins and peptides. In: Zheng W, Chodobski A, eds. The Blood-Cerebrospinal Fluid Barrier. Boca Raton, FL: CRC Press, 2005: 307–339.

    Google Scholar 

  17. Pullen RG, DePasquale M, Cserr HF. Bulk flow of cerebrospinal fluid into brain in response to acute hyperosmolality. Am J Physiol 1987; 253: F538–45.

    PubMed  CAS  Google Scholar 

  18. Husted RF, Reed DJ. Regulation of cerebrospinal fluid bicarbonate by the cat choroid plexus. J Physiol 1977; 267: 411–28.

    PubMed  CAS  Google Scholar 

  19. Keep RF, Xiang J. Choroid plexus potassium cotransport: modulation by osmotic stress and external potassium. J Neurochem 1995; 64: 2747–54.

    Article  PubMed  CAS  Google Scholar 

  20. Egnor M, Zheng L, Rosiello A, Gutman F, Davis R. A model of pulsations in communicating hydrocephalus. Pediatr Neurosurg 2002; 36: 281–303.

    Article  PubMed  Google Scholar 

  21. Wijnholds J, deLange EC, Scheffer GL, van den Berg DJ, Mol CA, van der Valk M, Schinkel AH, et al. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 2000; 105: 279–85.

    Article  PubMed  CAS  Google Scholar 

  22. James WG, Hutchinson P, Bullard DC, Hickey MJ. Cerebral leucocyte infiltration in lupus-prone MRL/MpJ-fas lpr mice—roles of intercellular adhesion molecule-1 and P-selectin. Clin Exp Immunol 2006; 144: 299–308.

    Article  PubMed  CAS  Google Scholar 

  23. Fujikawa T, Soya H, Yoshizato H, Sakaguchi K, Doh-Ura K, Tanaka M, Nakashima K. Restraint stress enhances the gene expression of prolactin receptor long form at the choroid plexus. Endocrinology 1995; 136: 5608–13.

    Article  PubMed  CAS  Google Scholar 

  24. Spector R, Johanson C. The mammalian choroid plexus. Sci Am 1989; 260: 68–74.

    Article  Google Scholar 

  25. Gross PM, ed. Circumventricular Organs and Body Fluids. Boca Raton, FL: CRC Press, 1987.

    Google Scholar 

  26. Williams JL, Thebert MM, Schalk KA, Heistad DD. Stimulation of area postrema decreases blood flow to choroid plexus. Am J Physiol 1991; 260: H902–H908.

    PubMed  CAS  Google Scholar 

  27. Allen DD, Yokel RA. Dissimilar aluminum and gallium permeation of the blood-brain barrier demonstrated by in vivo microdialysis. J Neurochem 1992; 58: 903–8.

    Article  PubMed  CAS  Google Scholar 

  28. Faraci FM, Mayhan WG, Farrell WJ, Heistad DD. Humoral regulation of blood flow to choroid plexus: role of arginine vasopressin. Circ Res 1988; 63: 373–9.

    Article  PubMed  CAS  Google Scholar 

  29. Rapoport SI, ed. Blood-Brain Barrier in Physiology and Medicine. New York: Raven Press, 1976.

    Google Scholar 

  30. Grzybowski DM, Herderick EE, Kapoor KG, Holman DW, Katz SE. Human arachnoid granulations. Part I: A technique for quantifying area and distribution on the superior surface of the cerebral cortex. Cerebrospinal Fluid Res 2007; 4: 6.

    Google Scholar 

  31. Nagra G, Koh L, Zakharov A, Armstrong D, Johnston M. Quantification of cerebrospinal fluid transport across the cribriform plate into lymphatics in rats. Am J Physiol 2006; 291: R1383–9.

    CAS  Google Scholar 

  32. Bradbury MW, Cserr HF, Westrop RJ. Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit. Am J Physiol 1981; 240: F329–36.

    PubMed  CAS  Google Scholar 

  33. Luedemann W, Kondziella D, Tienken K, Klinge P, Brinker T, Berens von Rautenfeld D. Spinal cerebrospinal fluid pathways and their significance for the compensation of kaolin-hydrocephalus. Acta Neurochir Suppl. 2002; 81: 271–3.

    PubMed  CAS  Google Scholar 

  34. Kivisäkk P, Mahad DJ, Callahan MK, Trebst C, Tucky B, Wei T, Wu L, Baekkevold ES, Lassmann H, Staugaitis SM, Campbell JJ, Ransohoff RM. Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci U S A 2003; 100: 8389–94.

    Article  PubMed  Google Scholar 

  35. Owen-Lynch PJ, Draper CE, Mashayekhi F, Bannister CM, Miyan JA. Defective cell cycle control underlies abnormal cortical development in the hydrocephalic Texas rat. Brain 2003; 126: 623–31.

    Article  PubMed  Google Scholar 

  36. Skinner SJ, Geaney MS, Rush R, Rogers ML, Emerich DF, Thanos CG, Vasconcellos AV, Tan PL, Elliott RB. Choroid plexus transplants in the treatment of brain diseases. Xenotransplantation 2006; 13: 284–8.

    Article  PubMed  Google Scholar 

  37. Walter HJ, Berry M, Hill DJ, Cwyfan-Hughes S, Holly JM, Logan A. Distinct sites of insulin-like growth factor (IGF)-II expression and localization in lesioned rat brain: possible roles of IGF binding proteins (IGFBPs) in the mediation of IGF-II activity. Endocrinology 1999; 140: 520–32.

    Article  PubMed  CAS  Google Scholar 

  38. Johanson CE, McMillan PN, Palm DE, Stopa EG, Doberstein CE, Duncan JA. Volume transmission-mediated protective impact of choroid plexus-CSF growth factors on forebrain ischemic injury. In: Sharma HS and Westman J, eds. Blood-Spinal Cord and Brain Barriers in Health and Disease. San Diego: Academic Press, 2003: 361–384.

    Google Scholar 

  39. Sharma HS, Johanson CE. Intracerebroventricularly administered neurotrophins attenuate blood cerebrospinal fluid barrier breakdown and brain pathology following whole-body hyperthermia: an experimental study in the rat using biochemical and morphological approaches. Ann N Y Acad Sci 2007; 1122: 112–29.

    Google Scholar 

  40. Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med 2007; 13: 1029–31.

    Google Scholar 

  41. Silverberg GD, Mayo M, Saul T, Rubenstein E, McGuire D. Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol 2003; 2: 506–11.

    Article  PubMed  Google Scholar 

  42. Preston JE. Ageing choroid plexus-cerebrospinal fluid system. Microsc Res Tech 2001; 52: 31–7.

    Article  PubMed  CAS  Google Scholar 

  43. Rubenstein E. Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged. Lancet 1998; 351: 283–5.

    Article  PubMed  CAS  Google Scholar 

  44. Parandoosh Z, Johanson CE. Ontogeny of blood-brain barrier permeability to, and cerebrospinal fluid sink action on, [14C]urea. Am J Physiol 1982; 243: R400–7.

    PubMed  CAS  Google Scholar 

  45. McCormack EJ, Egnor MR, Wagshul ME. Improved cerebrospinal fluid flow measurements using phase contrast balanced steady-state free precession. Magn Reson Imaging 2007; 25: 172–82.

    Article  PubMed  Google Scholar 

  46. Smith DE, Johanson CE, Keep RF. Peptide and peptide analog transport systems at the blood-CSF barrier. Adv Drug Deliv Rev 2004; 56: 1765–91.

    Article  PubMed  CAS  Google Scholar 

  47. Nilsson C, Lindvall-Axelsson M, Owman C. Neuroendocrine regulatory mechanisms in the choroid plexus-cerebrospinal fluid system. Brain Res Rev 1992; 17: 109–138.

    Article  PubMed  CAS  Google Scholar 

  48. Stopa EG, Berzin TM, Kim S, Song P, Kuo-LeBlanc V, Rodriguez-Wolf M, Baird A, Johanson CE. Human choroid plexus growth factors: What are the implications for CSF dynamics in Alzheimer's disease? Exp Neurol 2001; 167: 40–7.

    Article  PubMed  CAS  Google Scholar 

  49. Mehta BC, Holman DW, Grzybowski DM, Chalmers JJ. Characterization of arachnoidal cells cultured on three-dimensional nonwoven PET matrix. Tissue Eng 2007; 13: 1269–79.

    Article  PubMed  CAS  Google Scholar 

  50. Johnston M, Armstrong D, Koh L. Possible role of the cavernous sinus veins in cerebrospinal fluid absorption. Cerebrospinal Fluid Res 2007; 4: 3

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Program in Neurosurgery, Department of Clinical Neurosciences, Warren Alpert Medical School, Brown University, Providence, RI, USA

    Conrad E. Johanson PhD

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  1. Conrad E. Johanson PhD
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Editors and Affiliations

  1. Oregon National Primate Research Center, Div. Neuroscience, Oregon Health and Science University, 505 NW 185th Ave, Beaverton OR 97006, USA

    P. Michael Conn

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Johanson, C.E. (2008). Choroid Plexus–Cerebrospinal Fluid Circulatory Dynamics: Impact on Brain Growth, Metabolism, and Repair. In: Conn, P.M. (eds) Neuroscience in Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-455-5_11

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