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Protein Crystallizability

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Data Mining Techniques for the Life Sciences

Part of the book series: Methods in Molecular Biology ((MIMB,volume 609))

Abstract

Obtaining well-diffracting crystals remains a major challenge in protein structure research. In this chapter, we review currently available computational methods to estimate the crystallization potential of a protein, to optimize amino acid sequences toward improved crystallization likelihood, and to design optimal crystal screen conditions.

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Authors and Affiliations

  1. MIPS & Helmholz Institute München, Martinsried, Germany

    Pawel Smialowski & Dmitrij Frishman

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  1. Pawel Smialowski
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  2. Dmitrij Frishman
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Editors and Affiliations

  1. Max F. Perutz Laboratories GmbH, Universität Wien, Dr. Bohr-Gasse 9, Wien, 1030, Austria

    Oliviero Carugo

  2. Research (A*STAR), Agency for Science & Technology, Biopolis Street 30, Singapore, 138671, Singapore

    Frank Eisenhaber

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Smialowski, P., Frishman, D. (2010). Protein Crystallizability. In: Carugo, O., Eisenhaber, F. (eds) Data Mining Techniques for the Life Sciences. Methods in Molecular Biology, vol 609. Humana Press. https://doi.org/10.1007/978-1-60327-241-4_22

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  • DOI: https://doi.org/10.1007/978-1-60327-241-4_22

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