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Microenvironmental Regulation of Adult Mesenchymal Stem Cells

  • Chapter
Regulatory Networks in Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

This chapter aims to present the importance of the cell-extrinsic factors that influence the identity and activities of adult mesenchymal stem cells (MSCs). The focus is on microenvironmental cues that represent a concert of signals coming from the niche in which the MSC finds itself. These signals are generated by contact with surrounding cells, by soluble factors that can be autocrine, paracrine, or endocrine in nature, and by the extracellular matrix surrounding the cell. Even fragments of matrix molecules and small molecules like oxygen can influence the behavior of an MSC. In vivo, these signals work together in intricate harmony to regulate the regenerative abilities of MSCs. By learning more about the mechanisms of action, specificities and interactions of each member of this environmental orchestra, it will be possible to manipulate MSCs for therapeutic applications to diseases and injuries.

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Notes

  1. 1.

    The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA

    Thomas P. Lozito, Catherine M. Kolf & Rocky S. Tuan

  2. Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1523, MSC 8022, 20892-8022, Bethesda, MD, USA

    Thomas P. Lozito, Catherine M. Kolf & Rocky S. Tuan

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  1. Thomas P. Lozito
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  2. Catherine M. Kolf
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  3. Rocky S. Tuan
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  1. Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Vinagolu K. Rajasekhar MSc, MPhil, PhD

  2. Invitrogen Corporation, Frederick, MD, USA

    Mohan C. Vemuri Ph.D.

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC, a part of Springer Science+Business Media, LLC

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Lozito, T.P., Kolf, C.M., Tuan, R.S. (2009). Microenvironmental Regulation of Adult Mesenchymal Stem Cells. In: Rajasekhar, V.K., Vemuri, M.C. (eds) Regulatory Networks in Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-227-8_17

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