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Mitochondrial Proteome: Toward the Detection and Profiling of Disease Associated Alterations

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Molecular Profiling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 823))

Abstract

Existing at the heart of cellular energy metabolism, the mitochondrion is uniquely positioned to have a major impact on human disease processes. Examples of mitochondrial impact on human pathology abound and include etiologies ranging from inborn errors of metabolism to the site of activity of a variety of toxic compounds. In this review, the unique aspects of the mechanisms related to the mitochondrial proteome are discussed along with an overview of the literature related to mitochondrial proteomic exploration. The review includes discussion of potential areas for exploration and advantages of applying proteomic techniques to the study of mitochondria.

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Author information

Authors and Affiliations

  1. Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA, USA

    Paul C. Herrmann

  2. Department of Biochemistry and Microbiology, Loma Linda University, Loma Linda, CA, USA

    E. Clifford Herrmann

Authors
  1. Paul C. Herrmann
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  2. E. Clifford Herrmann
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Corresponding author

Correspondence to Paul C. Herrmann .

Editor information

Editors and Affiliations

  1. Center for Applied Proteomics and, George Mason University, University Blvd. 10900, Manassas, 20110, Virginia, USA

    Virginia Espina

  2. Center for Applied Proteomics &, George Mason University, University Blvd. 10900, Manassas, 20110, Virginia, USA

    Lance A. Liotta

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Herrmann, P.C., Herrmann, E.C. (2012). Mitochondrial Proteome: Toward the Detection and Profiling of Disease Associated Alterations. In: Espina, V., Liotta, L. (eds) Molecular Profiling. Methods in Molecular Biology, vol 823. Humana Press. https://doi.org/10.1007/978-1-60327-216-2_17

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  • DOI: https://doi.org/10.1007/978-1-60327-216-2_17

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-215-5

  • Online ISBN: 978-1-60327-216-2

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