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Clinical Uses of Microarrays in Cancer Research

  • Protocol
Clinical Bioinformatics

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 141))

Summary

Perturbations in genes play a key role in the pathogenesis of cancer. Microarray-based technology is an ideal way in which to study the effects and interactions of multiple genes in cancer. There are many technologic challenges in running a microarray study, including annotation of genes likely to be involved, designing the appropriate experiment, and ensuring adequate quality assurance steps are implemented. Once data are normalized, they need to be analyzed; and for this, there are numerous software packages and approaches.

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Abbreviations

GO:

gene ontology

RT-PCR:

reverse transcriptase PCR

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Author information

Authors and Affiliations

  1. University Health Network, Microarray Centre, Toronto Medical Discovery Tower, Toronto, Ontario, Canada

    Carl Virtanen

  2. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    James Woodgett

Authors
  1. Carl Virtanen
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  2. James Woodgett
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Editor information

Editors and Affiliations

  1. Department of Molecular and Clinical Genetics, University of Sydney Central Clinical School Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia

    Ronald J.A. Trent

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Virtanen, C., Woodgett, J. (2008). Clinical Uses of Microarrays in Cancer Research. In: Trent, R.J. (eds) Clinical Bioinformatics. Methods in Molecular Medicine™, vol 141. Humana Press. https://doi.org/10.1007/978-1-60327-148-6_6

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  • DOI: https://doi.org/10.1007/978-1-60327-148-6_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-791-4

  • Online ISBN: 978-1-60327-148-6

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